Poor osteochondral repair by a biomimetic collagen scaffold: 1- to 3-year clinical and radiological follow-up

Christensen, Bjørn Borsøe; Foldager, Casper Bindzus; Jensen, John; Jensen, Niels Christian; Lind, Martin

doi:10.1007/s00167-015-3538-3

Cited by 112 publications

(110 citation statements)

References 28 publications

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“…[95] However, a recent study reported inconsequential osteochondral recovery using this biomimetic scaffold. [92] Additionally, a major ambiguity in these studies is the absence of gold standards, therefore, no comparisons are made through controls. More recently, another approach for cartilage regeneration was explored using a decellularized cartilage based scaffold.…”

Section: Nanoengineered Bone-cartilage Interfacementioning

confidence: 99%

Nanoengineered biomaterials for repair and regeneration of orthopedic tissue interfaces

et al. 2016

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Section: Nanoengineered Bone-cartilage Interfacementioning

confidence: 99%

Nanoengineered biomaterials for repair and regeneration of orthopedic tissue interfaces

et al. 2016

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“…Natural biological materials, such as collagen and fibrin, are promising candidate scaffolds for cartilage engineering [15,16] as they play multiple key roles in structural maintenance of the defect shape and void volume for vascularization, and serve as temporary extracellular matrix for cell adhesion, proliferation, differentiation, and maturation [17,18]. Collagen scaffolds have been actively used in research as well as in clinical applications for meniscus and osteochondral defect regeneration [19]. The most widely used collagen in biomedical applications is collagen type I that provides a welcoming microenvironment for chondrocytes to produce extracellular matrix [20,21].…”

Section: Introductionmentioning

confidence: 99%

Chitosan-Coated Collagen Membranes Promote Chondrocyte Adhesion, Growth, and Interleukin-6 Secretion

et al. 2015

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Designing scaffolds made from natural polymers may be highly attractive for tissue engineering strategies. We sought to produce and characterize chitosan-coated collagen membranes and to assess their efficacy in promoting chondrocyte adhesion, growth, and cytokine secretion. Porous collagen membranes were placed in chitosan solutions then crosslinked with glutaraldehyde vapor. Fourier transform infrared (FTIR) analyses showed elevated absorption at 1655 cm−1 of the carbon–nitrogen (N=C) bonds formed by the reaction between the (NH2) of the chitosan and the (C=O) of the glutaraldehyde. A significant peak in the amide II region revealed a significant deacetylation of the chitosan. Scanning electron microscopy (SEM) images of the chitosan-coated membranes exhibited surface variations, with pore size ranging from 20 to 50 μm. X-ray photoelectron spectroscopy (XPS) revealed a decreased C–C groups and an increased C–N/C–O groups due to the reaction between the carbon from the collagen and the NH2 from the chitosan. Increased rigidity of these membranes was also observed when comparing the chitosan-coated and uncoated membranes at dried conditions. However, under wet conditions, the chitosan coated collagen membranes showed lower rigidity as compared to dried conditions. Of great interest, the glutaraldehyde-crosslinked chitosan-coated collagen membranes promoted chondrocyte adhesion, growth, and interleukin (IL)-6 secretion. Overall results confirm the feasibility of using designed chitosan-coated collagen membranes in future applications, such as cartilage repair.

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“…Delcogliano and colleagues [39] reported a significant improvement of the evaluated clinical parameters (International Repair Cartilage Society score, the Tegner Score and EQ-VAS). The significant clinical improvements were confirmed by Christinseen et al [40] that however reported an incomplete cartilage repair and poor subchondral bone repair at 1-and 2.5-year follow-up by treatment of osteochondral defects in the ankle and knee joint with the graded biomimetic scaffold MaioRegen®.…”

Section: Bone-like Scaffolds: Bioceramic and Nano-composite Monolithimentioning

confidence: 53%

Recent Strategies in Osteochondral Substitutes Design: Towards the Mimicking of a Multifaceted Anatomical Unit from the Nano to the Macro Level

Palazzo¹,

Scalera²,

Soloperto³

et al. 2017

J Nanomed Nanotechnol

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Poor osteochondral repair by a biomimetic collagen scaffold: 1- to 3-year clinical and radiological follow-up

Abstract: Prospective therapeutic study, Level IV.

Cited by 112 publications

References 28 publications

Nanoengineered biomaterials for repair and regeneration of orthopedic tissue interfaces

Nanoengineered biomaterials for repair and regeneration of orthopedic tissue interfaces

Chitosan-Coated Collagen Membranes Promote Chondrocyte Adhesion, Growth, and Interleukin-6 Secretion

Recent Strategies in Osteochondral Substitutes Design: Towards the Mimicking of a Multifaceted Anatomical Unit from the Nano to the Macro Level

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