Poor Predictive Value of Intraoperative Real-Time Dosimetry for Prostate Seed Brachytherapy

Igidbashian, Levon; Donath, David; Carrier, Jean‐François; Lassalle, Stephanie; Hervieux, Yannick; David, Sandrine; Bahary, Jean-Paul; Taussky, Daniel

doi:10.1016/j.ijrobp.2008.06.1484

Cited by 14 publications

(6 citation statements)

References 21 publications

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“…The 20 Gy difference was chosen, because several studies have shown that discrepancies of that magnitude can occur between online- and post-plan D 90 (Table 1) [3–5]. Our study therefore involved reviewing 50 intra- and post-operative plans of patients who underwent a permanent I-125 implant of the prostate between March 2008 and March 2010.…”

Section: Methodsmentioning

confidence: 99%

Clinical Investigations Benefits of a dual sagittal crystal transducer for ultrasound imaging during I-125 seed implantation for permanent prostate brachytherapy

Kaljouw¹,

Pieters²,

Koedooder³

et al. 2012

jcb

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PurposeTo investigate whether a longer sagittal view and less movement using a dual sagittal crystal probe (DSCP) for trans rectal ultra sound (TRUS) allow for more accurate online-planning in I-125 permanent implant brachytherapy of the prostate, compared to a single sagittal crystal probe (SSCP).Material and methodsBetween March 2008 and March 2010, 50 patients with prostate cancer were consecutively included in the study. The first 25 of these patients had both their pre- and online-planning based on a single sagittal crystal probe (SSCP). The treatment-plans of the other 25 patients were based on a DSCP TRUS. Three weeks after implantation a post-planning was made based on CT. TRUS online and CT post-plan dose-volume histogram (DVH) parameters, D90 and V100, were compared for both groups. Also, the post-plan DVH parameters of SSCP were compared to DSCP. The possible factors that might influence the post-plan D90 and V100 were analysed using Analysis of Variance (ANOVA).ResultsSSCP and DSCP online mean D90 and V100 were significantly larger than post-plan mean D90 and V100 (P < 0.01). The post-plan mean D90 and mean V100 were both non-significantly larger for SSCP based post-plans compared to DSCP based post plans (P = 0.76 and P = 0.68). ANOVA showed significant impact of prostate volume on the post-plan D90 and V100.ConclusionsThe advantages of the dual sagittal crystal probe did not lead to more accurate online planning by investigating DVH-parameters. The only factor found to have influence on the DVH-parameters was the prostate volume.

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Section: Methodsmentioning

confidence: 99%

Clinical Investigations Benefits of a dual sagittal crystal transducer for ultrasound imaging during I-125 seed implantation for permanent prostate brachytherapy

Kaljouw¹,

Pieters²,

Koedooder³

et al. 2012

jcb

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“…The brachytherapy technique used here was previously described by Igidbashian et al (6). Before implantation, all patients underwent a volume study to determine pubic arch interference.…”

Section: Methodsmentioning

confidence: 99%

Comparison Between High and Low Source Activity Seeds for I-125 Permanent Seed Prostate Brachytherapy

Masucci

Donath

Tétreault-Laflamme

et al. 2010

International Journal of Radiation Oncology*Biology*Physics

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“…This consisted of interactive planning with modification of the treatment based on the feedback of the real-time tracking of the actual needle positions and a continuous feedback of the seed positions as they were implanted [ 2 ]. In 2008, we described our results with an interactive planning technique using real-time three-dimensional (3D) transrectal ultrasound (TRUS) for dose planning and IO navigation [ 3 ], and reported the clinical outcome, toxicity [ 4 , 5 ], and seed loss [ 6 ] for low to high activity seeds. We described that IO dosimetric parameters on TRUS could predict a good quality implant on the Day 30 computed tomography (CT) scan.…”

Section: Purposementioning

confidence: 99%

“…We described that IO dosimetric parameters on TRUS could predict a good quality implant on the Day 30 computed tomography (CT) scan. We also discovered that a good IO preimplant plan was the best predictive factor of a good implant on Day 30 [ 3 ]. In this present study, we updated our experience with a larger than previously described cohort and investigated whether IO TRUS-based dosimetry was predictive of biochemical recurrence (BR).…”

Section: Purposementioning

confidence: 99%

Is intraoperative real-time dosimetry in prostate seed brachytherapy predictive of biochemical outcome?

Taussky

Igidbashian

Donath

et al. 2017

jcb

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PurposeTo analyze intraoperative (IO) dosimetry using transrectal ultrasound (TRUS), performed before and after prostate low-dose-rate brachytherapy (LDR-BT), and compare it to dosimetry performed 30 days following the LDR-BT implant (Day 30).Material and methodsA total of 236 patients underwent prostate LDR-BT using 125I that was performed with a three-dimensional TRUS-guided interactive inverse preplanning system (preimplant dosimetry). After the implant procedure, the TRUS was repeated in the operating room, and the dosimetry was recalculated (postimplant dosimetry) and compared to dosimetry on Day 30 computed tomography (CT) scans. Area under curve (AUC) statistics was used for models predictive of dosimetric parameters at Day 30.ResultsThe median follow-up for patients without BF was 96 months, the 5-year and 8-year biochemical recurrence (BR)-free rate was 96% and 90%, respectively. The postimplant median D90 was 3.8 Gy lower (interquartile range [IQR], 12.4-0.9), and the V100 only 1% less (IQR, 2.9-0.2%) than the preimplant dosimetry. When comparing the postimplant and the Day 30 dosimetries, the postimplant median D90 was 9.6 Gy higher (IQR [–] 9.5-30.3 Gy), and the V100 was 3.2% greater (0.2-8.9%) than Day 30 postimplant dosimetry. The variables that best predicted the D90 of Day 30 was the postimplant D90 (AUC = 0.62, p = 0.038). None of the analyzed values for IO or Day 30 dosimetry showed any predictive value for BR.ConclusionsAlthough improving the IO preimplant and postimplant dosimetry improved dosimetry on Day 30, the BR-free rate was not dependent on any dosimetric parameter. Unpredictable factors such as intraprostatic seed migration and IO factors, prevented the accurate prediction of Day 30 dosimetry.

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Poor Predictive Value of Intraoperative Real-Time Dosimetry for Prostate Seed Brachytherapy

Cited by 14 publications

References 21 publications

Clinical Investigations Benefits of a dual sagittal crystal transducer for ultrasound imaging during I-125 seed implantation for permanent prostate brachytherapy

Clinical Investigations Benefits of a dual sagittal crystal transducer for ultrasound imaging during I-125 seed implantation for permanent prostate brachytherapy

Comparison Between High and Low Source Activity Seeds for I-125 Permanent Seed Prostate Brachytherapy

Is intraoperative real-time dosimetry in prostate seed brachytherapy predictive of biochemical outcome?

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