Poorly differentiated cutaneous squamous cell carcinoma with osteoclast‐like giant cell: A rare, aggressive variant

Abstract

Key Clinical Message Squamous Cell Carcinoma (SCC) with Osteoclast‐like giant cell (OLGC) is a rare SCC variant; only 10 cases have been reported. Our case suggests OLGC are resultant of a reactive process, driven by the fusion of adjacent macrophages. Knowledge regarding SCC with OLGC is of great importance as this entity has greater prometastatic potential compared to conventional SCC.