Poorly differentiated endocrine carcinoma and intraductal papillary-mucinous neoplasm of the pancreas: Description of an unusual case

Stukavec, J; Jirásek, Tomáš; Mandys, Václav; Denemark, L; Havlůj, Lukáš; Sosna, Bohuslav; Kosmahl, Markus; Zádorová, Zdena

doi:10.1016/j.prp.2007.08.012

Cited by 19 publications

(16 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Table I summarizes the clinicopathological features of the 15 previously reported cases of concomitant IPMN and NET (3,(5)(6)(7)(8)(9) as well as the present case. This condition mainly affects middle-aged females (average age, 63.1 years; range, 40-76 years; male/female ratio, 5:11).…”

Section: Discussionmentioning

confidence: 92%

Concomitant intraductal papillary mucinous neoplasm and neuroendocrine tumor of the pancreas

et al. 2012

View full text Add to dashboard Cite

Abstract. Intraductal papillary mucinous neoplasm (IPMN) and neuroendocrine tumor (NET) of the pancreas are rare tumors and their association is not expected to be frequent. However, certain studies have suggested that the concomitant occurence of these tumors may be more frequent than previously thought. In the current study, we describe a case of concomitant occurrence of IPMN and NET of the pancreas and review the clinicopathological features of previously published cases and the current one. A 68-year-old female was incidentally found to have dilatation of the main pancreatic duct. A distal pancreatectomy was performed under the clinical diagnosis of IPMN. Histopathological analysis revealed concomitant IPMN (low-grade) and NET G1 of the pancreas. Review of the clinicopathological features of the 15 previously reported cases of concomitant IPMN and NET of the pancreas as well as the present one indicated that: i) this condition mainly affects middle-aged females; ii) the main symptom is abdominal or back pain, or no symptoms; iii) a hormone production symptom was observed in only one case; iv) the most common degree of dysplasia of IPMN is low grade; and v) the size of the NET is not particularly large (average 15.1 mm), although the clinical behavior is not always indolent (metastasis was observed in 3 cases). It is well known that IPMNs are associated with a high incidence of extrapancreatic malignancies, including colorectal and gastric carcinomas. Concomitant pancreatic NET and extrapancreatic malignancies may occur, therefore, systemic surveillance of extrapancreatic neoplasms and detection of concomitant NETs of the pancreas are necessary for patients with IPMN. IntroductionIntraductal papillary mucinous neoplasm (IPMN) is a rare intraductal epithelial neoplasm composed of mucin-producing cells arising in the main pancreatic duct or its branches (1). IPMNs are estimated to account for 1-3% of exocrine pancreatic neoplasms and 20% of all cystic neoplasms of the pancreas, and the incidence of this disease is considered to be increasing (1). The subtypes of IPMNs are recognized as main-duct and branch-duct types by macroscopic examination, and noninvasive IPMNs are classified into three categories on the basis of cytoarchitectural atypia: low-, intermediate-and high-grade dysplasia (1).Pancreatic neuroendocrine neoplasms are uncommon and represent 1-2% of all pancreatic neoplasms (2). According to the recent World Health Organization Classification of the Digestive System, neuroendocrine neoplasms are classified into three categories: neuroendocrine tumor (NET) G1 and G2 and neuroendocrine carcinoma (NEC; NET G3) (2).IPMN and NET of the pancreas are rare tumors and their association is not expected to be frequent. However, certain studies have suggested that the concomitant occurrence of these tumors may be more frequent than previously thought (3). In the current study, we describe a case of concomitant occurrence of IPMN and NET of the pancreas, and review the clinicopathological features of previously ...

show abstract

Section: Discussionmentioning

confidence: 92%

Concomitant intraductal papillary mucinous neoplasm and neuroendocrine tumor of the pancreas

et al. 2012

View full text Add to dashboard Cite

show abstract

“…The simultaneous occurrence of pancreatic endocrine tumor and IPMN has been previously described, and to date, 13 such patients have been reported in the literature [8][9][10][11][12]. The neuroendocrine tumors in all but 1 case have been well differentiated.…”

Section: Discussionmentioning

confidence: 93%

Pseudointraductal papillary mucinous neoplasia caused by microscopic periductal endocrine tumors of the pancreas: a report of 3 cases

Kenney¹,

Singh²,

Salem³

et al. 2011

Human Pathology

View full text Add to dashboard Cite

“…However, Stukavec J et al do not support this hypothesis, and suggest that the association is fortuitous and corresponds to a collision of two distinct tumors (5). Some studies corroborate this hypothesis and have shown that the incidence of small PNET is probably higher than previously thought due to the use of multiple imaging techniques such as EUS.…”

Section: Discussionmentioning

confidence: 95%

Synchronous intraductal papillary mucinous neoplasm and a pancreatic neuroendocrine tumor: more than a coincidence?

2017

View full text Add to dashboard Cite

Although the association between intraductal papillary mucinous neoplasm of the pancreas (IPMN) and pancreatic neuroendocrine tumor (PNET) has been increasingly reported, whether this association is real or coincidence remains unclear. We report a case of synchronous IPMN and a PNET which were diagnosed preoperatively and discuss the tumorigenesis, clinicopathological features and management of these rare tumors based on the published literature.A 56-year-old male was incidentally diagnosed with a 14 mm branch duct IPMN and a 3.6 mm non-functional PNET during an evaluation due to persistent upper abdominal pain via endoscopic ultrasound. Close follow-up of the patient was decided as the IPMN had no worrisome features.A review of twenty-two previously reported cases of synchronous IPMN and PNET indicated that: a) only seven cases were diagnosed preoperatively; b) abdominal pain was the main presenting symptom; c) IPMN was the dominant tumor and presented with low grade dysplasia; d) the PNET was small and non-functional and had an indolent behavior; and e) only one case underwent radiologic follow-up.IPMN are associated with other pancreatic and extrapancreatic malignancies. Thus, the entire pancreatic parenchyma should be examined closely during the evaluation of an IPMN in order to exclude other pancreatic lesions, for example, a PNET.

show abstract

Poorly differentiated endocrine carcinoma and intraductal papillary-mucinous neoplasm of the pancreas: Description of an unusual case

Cited by 19 publications

References 10 publications

Concomitant intraductal papillary mucinous neoplasm and neuroendocrine tumor of the pancreas

Concomitant intraductal papillary mucinous neoplasm and neuroendocrine tumor of the pancreas

Pseudointraductal papillary mucinous neoplasia caused by microscopic periductal endocrine tumors of the pancreas: a report of 3 cases

Synchronous intraductal papillary mucinous neoplasm and a pancreatic neuroendocrine tumor: more than a coincidence?

Contact Info

Product

Resources

About