Poorly differentiated synovial sarcoma: A case report

Cappello, Francesco; Bellafiore, Marianna; Bucchieri, Fabio; Balsano, G.; Palma, Antonio; Zummo, Giovanni

doi:10.1007/bf03032608

Cited by 7 publications

(4 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Synovial sarcomas have previously been found to be reactive for D2-40 24 and calretinin. 15,[56][57][58] Unfortunately, we were able to obtain sufficient FISH signals in only 18% of the tumors. This low number might be due to different fixation procedures used in different institutions, but the presence of synovial sarcomas could be ruled out at least in these cases (Figure 3).…”

Section: Discussionmentioning

confidence: 94%

D2-40 and calretinin—a tissue microarray analysis of 341 malignant mesotheliomas with emphasis on sarcomatoid differentiation

et al. 2007

View full text Add to dashboard Cite

Anti-calretinin antibodies are useful to differentiate adenocarcinomas from malignant mesotheliomas of the lung. Therefore, calretinin expression is rarely reported for sarcomatoid mesotheliomas. Anti-podoplanin antibodies (eg D2-40) react with lymphatic endothelia, Kaposi's sarcoma, lymphangioma and mesotheliomas. For the interpretation of spindle cell lesions of the pleura, knowledge of calretinin and D2-40 expression frequencies in sarcomatoid mesothelioma is desirable. To systematically investigate the sensitivity of calretinin and D2-40 antibodies in epithelioid and sarcomatoid areas of malignant mesotheliomas, a tissue microarray with 341 malignant mesotheliomas, including 112 epithelioid, 46 sarcomatoid and 183 biphasic tumors was constructed. Epithelioid and sarcomatoid differentiated tumor areas were clearly separated within the tissue microarray. Expression of calretinin and D2-40 was separately studied in epithelioid and sarcomatoid areas by immunohistochemistry. Calretinin expression was found in 91% of epithelioid and 57% of sarcomatoid tumor areas. D2-40 immunostaining was present in 66% of the epithelioid and 30% of the sarcomatoid tumor areas. A combination of calretinin and D2-40 increased the sensitivity in epithelioid tumor areas to 0.96 and in sarcomatoid tumor areas to 0.66. These data indicate that a combination of calretinin and D2-40 will improve diagnostic accuracy for spindle cell lesions of the pleura, whereas almost all epithelioid mesotheliomas are identified by calretinin alone. Modern Pathology (2007) 20, 248-255.

show abstract

Section: Discussionmentioning

confidence: 94%

D2-40 and calretinin—a tissue microarray analysis of 341 malignant mesotheliomas with emphasis on sarcomatoid differentiation

et al. 2007

View full text Add to dashboard Cite

show abstract

“…In the study by Attanoos et al none of the 30 spindle cell neoplasms expressed calretinin, 18 but other studies have reported calretinin expression in a variety of spindle cell neoplasms, including synovial sarcoma, malignant peripheral nerve sheath tumour, solitary fibrous tumour, and cardiac myxoma. [10][11][12][13][14] Hence, calretinin positivity in spindle cell neoplasms must be interpreted with caution.…”

Section: Discussionmentioning

confidence: 99%

“…[6][7][8][9] However, calretinin positivity has been demonstrated in a small number of benign spindle cell neoplasms and sarcomas. [10][11][12][13][14] In our study, we describe a case of a recurrent sarcomatoid AGCT that clinically mimicked a primary colonic tumour and histologically was suggestive of a malignant gastrointestinal stromal tumour (GIST), and evaluate the usefulness of antibodies against inhibin and calretinin in differentiating sarcomatoid AGCT from various sarcomas.…”

mentioning

confidence: 99%

Inhibin is more specific than calretinin as an immunohistochemical marker for differentiating sarcomatoid granulosa cell tumour of the ovary from other spindle cell neoplasms

Shah

Freites²,

Maxwell³

et al. 2003

Journal of Clinical Pathology

View full text Add to dashboard Cite

“…It is thought to arise from primitive pluripotent mesenchymal cells rather than the synovium [2]. SCS is the third most common sarcoma of the extremities after liposarcoma and malignant fibrous histiocytoma [3] and has been found to account for 5 - 14% of soft tissue sarcomas in different studies [1,4,5].…”

Section: Discussionmentioning

confidence: 99%

Giant synovial cell sarcoma of the thorax in a 46-year-old man: a case report

Fatimi

Saleem

2009

Cases Journal

View full text Add to dashboard Cite

BackgroundAlthough synovial cell sarcoma is a common tumor of the extremities, its occurrence in the thorax has been less frequently documented.Case presentationA 46-year-old Pakistani man presented with a 2 month history of progressively increasing cough and left lower chest pain. Initial evaluation was done using a chest x-ray; the patient was found to have a large mass involving the lower portion of the left chest. A computed tomography scan was performed next which showed a large mass involving the left chest wall with invasion into the pericardium and left hemidiaphragm. En bloc surgical resection of the tumor was undertaken. Final pathology showed synovial cell sarcoma of the thorax. At one-year follow-up, the patient has shown no recurrence of the disease.ConclusionWe have described a rare case of a large synovial cell sarcoma of the thorax. Surgical resection appears an appropriate modus operandi for managing giant synovial cell sarcomas of the thorax. However, there is a need to clearly define post-operative strategies for cases with extensive involvement of surrounding structures.

show abstract

Poorly differentiated synovial sarcoma: A case report

Cited by 7 publications

References 23 publications

D2-40 and calretinin—a tissue microarray analysis of 341 malignant mesotheliomas with emphasis on sarcomatoid differentiation

D2-40 and calretinin—a tissue microarray analysis of 341 malignant mesotheliomas with emphasis on sarcomatoid differentiation

Inhibin is more specific than calretinin as an immunohistochemical marker for differentiating sarcomatoid granulosa cell tumour of the ovary from other spindle cell neoplasms

Giant synovial cell sarcoma of the thorax in a 46-year-old man: a case report

Contact Info

Product

Resources

About