Pop-up paper electrochemical device for label-free hepatitis B virus DNA detection

Point-of-care diagnostics for infectious diseases: From methods to devices

“…In the past decade, there have been a number of articles reported about development of μ PADs for POC detection of virus infections, including influenza virus [404] , chikungunya virus [405] , HCV [406] , West Nile virus [407] , HBV [408] , HPV [409] , HIV [410] , and so on. For example, Srisomwat et al developed a pop-up DNA based 3D μ PAD platform for label-free electrochemical detection of HBV DNA [408] . The 3D μ PAD platform integrated multi-step operation of detection into a single device with facile sample introduction, avoiding contamination and minimizing biofluids exposure.…”

COVID-19: A challenge for electrochemical biosensors

“…Viral nucleic acids are definitely the ideal target since they are suitable for early stage-detection when the IgM and IgG immune responses are still too low. Myriad studies have reported hybridization electrochemical biosensors aimed at viral nucleic acids and have claimed their reliable detection [ [27] , [28] , [29] , [30] , [31] , [32] ]. However, most of these studies have used synthetic oligonucleotides as analytes, which are often just slightly longer than the corresponding probes.…”

Electrochemical diagnostics of infectious viral diseases: Trends and challenges

“…Paper based electrochemical aptasensor have been emerged as the alternative to PET based screen printed electrodes for the detection various viruses, such as hepatitis B ( Srisomwat et al, 2021 , 2020 ), hepatitis C ( Zhao and Liu, 2016 ), chikungunya ( Singhal et al, 2018a ), zika virus ( Dolai and Tabib-Azar, 2020 ) and papilloma virus ( Teengam et al, 2017 ). Dolai S et al developed a paper based microfluidic platform for the zika virus detection using potentiometric transduction method ( Dolai and Tabib-Azar, 2020 ).…”