Population-Based Study of Birth Prevalence and Factors Associated with Cleft Lip and/or Palate in Taiwan 2002–2009

Lei, Ruoh Lih; Chen, Huey Shys; Huang, Bao Yuan; Chen, Yueh Chih; Kuo, John S.; Lee, Huei Ying; Chang, Ching-Wei; Wu, Chih Lung

doi:10.1371/journal.pone.0058690

Cited by 44 publications

(42 citation statements)

References 18 publications

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“…The present findings revealed a significantly lower birthweight of infants with CPO as compared to the control groups. The same trend has been described in populations in Iran, Taiwan and Uganda …”

Section: Discussionsupporting

confidence: 83%

Maternal‐related factors in the origin of isolated cleft palate—A population‐based case‐control study

Ács

Bányai

Nemes

et al. 2020

Orthod Craniofacial Res

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Objects Isolated cleft palate (CPO) is the rarest form of oral clefting affecting 1‐25 per 10 000 newborns worldwide. There is increasing evidence for the different pathogenetic backgrounds of CPO and cleft lip with or without cleft palate. The role of environmental factors in the origin of non‐syndromic and syndromic CPO is unclear in most patients. The aim of this study was to estimate possible maternal risk factors in the origin of CPO. Setting and Sample Population The Hungarian Case‐Control Surveillance of Congenital Abnormalities contains data of 32 345 birth defect cases and 57 231 control newborns. The study samples included 751 cases with isolated CPO, 1196 matched controls and 57 231 population controls. Material and Methods Maternal diseases during pregnancy in cases and population controls were compared, and adjusted ORs with 95% CI were calculated in a multivariable unconditional logistic regression model. Results Beyond the well‐known robust female excess (58.9%)—maternal smoking (OR with 95% CI: 2.34, 1.94‐2.81) medically recorded maternal anaemia, threatened abortion and excessive vomiting in pregnancy were associated with a higher risk for CPO in the offspring. An elevated risk was found in Graves’ disease (OR: 4.30, 1.74‐10.62), epilepsy (OR: 4.64, 2.44‐8.82), migraine (OR: 2.82, 1.18‐6.76) and essential hypertension (OR: 2.33, 1.32‐4.10). Among acute diseases common cold (OR: 4.94, 3.48‐7.03), acute respiratory infections (OR: 4.20, 1.49‐11.82), influenza (OR: 2.95, 1.75‐4.95), pulpitis (OR: 7.85, 2.80‐22.03), cholecystitis (OR: 3.15, 1.16‐8.60), acute urinary tract infections (OR: 4.08, 2.22‐7.49) and pelvic inflammatory diseases (OR: 3.93, 1.62‐9.53) during pregnancy also were associated with an increased risk for developing CPO. Conclusion The findings of this study suggest that maternal diseases and lifestyle factors during the first trimester play a significant role in the development of isolated cleft palate.

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Section: Discussionsupporting

confidence: 83%

Maternal‐related factors in the origin of isolated cleft palate—A population‐based case‐control study

Ács

Bányai

Nemes

et al. 2020

Orthod Craniofacial Res

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“…The incidence of the anomaly worldwide is 0.3 to 1.9 per thousand live births [1–3], and the average incidence is 0.8 per thousand live births [1]. China is one of the countries with a high incidence of NSCL/P, at 1.3 per thousand live births [4], which is higher than the world’s average level.…”

Section: Introductionmentioning

confidence: 99%

A discriminant analysis prediction model of non-syndromic cleft lip with or without cleft palate based on risk factors

Luo

et al. 2016

BMC Pregnancy Childbirth

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BackgroundA risk prediction model of non-syndromic cleft lip with or without cleft palate (NSCL/P) was established by a discriminant analysis to predict the individual risk of NSCL/P in pregnant women.MethodsA hospital-based case–control study was conducted with 113 cases of NSCL/P and 226 controls without NSCL/P. The cases and the controls were obtained from 52 birth defects’ surveillance hospitals in Hunan Province, China. A questionnaire was administered in person to collect the variables relevant to NSCL/P by face to face interviews. Logistic regression models were used to analyze the influencing factors of NSCL/P, and a stepwise Fisher discriminant analysis was subsequently used to construct the prediction model.ResultsIn the univariate analysis, 13 influencing factors were related to NSCL/P, of which the following 8 influencing factors as predictors determined the discriminant prediction model: family income, maternal occupational hazards exposure, premarital medical examination, housing renovation, milk/soymilk intake in the first trimester of pregnancy, paternal occupational hazards exposure, paternal strong tea drinking, and family history of NSCL/P. The model had statistical significance (lambda = 0.772, chi-square = 86.044, df = 8, P < 0.001). Self-verification showed that 83.8 % of the participants were correctly predicted to be NSCL/P cases or controls with a sensitivity of 74.3 % and a specificity of 88.5 %. The area under the receiver operating characteristic curve (AUC) was 0.846.ConclusionsThe prediction model that was established using the risk factors of NSCL/P can be useful for predicting the risk of NSCL/P. Further research is needed to improve the model, and confirm the validity and reliability of the model.

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“…In England, the incidence of clefts is 1.42/1,000 infants . A recent study in Taiwan found a birth rate of 3.2/1,000 facial cleft deformities in newborns . The overall incidence of clefts in Finland is 2.56/1,000 live births and abortions.…”

mentioning

confidence: 99%

Dental treatment need and dental general anesthetics among preschool‐age children with cleft lip and palate in northern Finland

Lehtonen

Sándor

Ylikontiola

et al. 2015

European J Oral Sciences

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Cleft lip and palate incidence is high in northern Finland. This study aimed to investigate the proportion of children in need of restorative dental treatment among cleft lip and palate patients in northern Finland, as well as their need for dental treatment under general anesthesia. The records of 183 cleft lip and palate patients, treated in Oulu University Hospital from 1997 to 2013, were reviewed. Data on dental caries were analyzed in association with cleft type, considering also the presence of syndromes. The frequency of dental general anesthetic (DGA) use, and of treatments, were also analyzed. Dental treatment need was most frequently observed, in this rather limited study population, in patients with the most severe deformities, namely bilateral cleft lip and palate, of whom 60% had caries. Among the study population, 11.5% (n = 21) had a syndrome. Of those, 57.1% had dental caries at the age of 3 or 6 yr, and only four could be treated without a DGA. Dental treatment under general anesthesia was performed in 14.8% of cleft patients without a syndrome, but in 38.1% of those with a syndrome. General anaesthesia is required for the provision of dental care more often in cleft (17.5%) than in non-cleft (0.2%) patients, and especially for those with a syndrome.

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Population-Based Study of Birth Prevalence and Factors Associated with Cleft Lip and/or Palate in Taiwan 2002–2009

Cited by 44 publications

References 18 publications

Maternal‐related factors in the origin of isolated cleft palate—A population‐based case‐control study

Maternal‐related factors in the origin of isolated cleft palate—A population‐based case‐control study

A discriminant analysis prediction model of non-syndromic cleft lip with or without cleft palate based on risk factors

Dental treatment need and dental general anesthetics among preschool‐age children with cleft lip and palate in northern Finland

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