Population-Based Study of Trends and Variations in Radiotherapy as Part of Primary Treatment of Cancer in the Southern Netherlands Between 1988 and 2006, With an Emphasis on Breast and Rectal Cancer

Vulto, J.C.M.; Lybeert, Marnix L.M.; Louwman, Marieke W. J.; Poortmans, Philip; Coebergh, Jan Willem

doi:10.1016/j.ijrobp.2008.08.074

Cited by 17 publications

(17 citation statements)

References 54 publications

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“…We retrospectively searched our medical and radiologic databases to identify all patients who met the following inclusion criteria: biopsy-proven prostate cancer and primary defi nitive treatment with external beam radiation therapy (with or without associated neoadjuvant or adjuvant androgen deprivation therapy); posttreatment 1.5-T endorectal MR imaging A pproximately 200 000 American men received a diagnosis of prostate cancer in 2009 ( 1 ), and up to 25% of them chose external beam radiation therapy as their defi nitive treatment (2)(3)(4). Patients treated with external beam radiation therapy are followed up with serial measurements of their serum prostatic-specifi c antigen (PSA) levels.…”

Section: Patient Populationmentioning

confidence: 99%

Locally Recurrent Prostate Cancer after External Beam Radiation Therapy: Diagnostic Performance of 1.5-T Endorectal MR Imaging and MR Spectroscopic Imaging for Detection

Westphalen¹,

Coakley²,

Roach³

et al. 2010

Radiology

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Purpose:To determine if performing magnetic resonance (MR) spectroscopic imaging, compared with performing T2-weighted MR imaging alone, improves the detection of locally recurrent prostate cancer after defi nitive external beam radiation therapy. Materials and Methods:This retrospective single-institution study was approved by the committee on human research, with a waiver of informed consent, and was compliant with HIPAA requirements. Sixty-four men who underwent endorectal MR imaging, MR spectroscopic imaging, and transrectal ultrasonographically guided biopsy for suspected local recurrence of prostate cancer after defi nitive external beam radiation therapy were retrospectively identifi ed. Thirty-three patients had also received androgen therapy. Recurrent cancer was determined to be present or absent in the left and right sides of the prostate at T2-weighted MR imaging and MR spectroscopic imaging by a radiologist and a spectroscopist, respectively. Area under the receiver operating characteristic curve (A Z ) was calculated for T2-weighted MR imaging alone and combined T2-weighted MR imaging and MR spectroscopic imaging by using generalized estimating equations and by using biopsy results as the reference standard. Results:Recurrent prostate cancer was identifi ed at biopsy in 37 (58%) of the 64 men. Recurrence was unilateral in 28 patients and bilateral in nine (total of 46 affected prostate sides). A Z analysis revealed that use of combined T2-weighted MR imaging and MR spectroscopic imaging ( A Z = 0.79), as compared with T2-weighted MR imaging alone ( A Z = 0.67), signifi cantly improved the detection of local recurrence ( P = .001). Conclusion:The addition of MR spectroscopic imaging to T2-weighted MR imaging signifi cantly improves the diagnostic accuracy of endorectal MR imaging in the detection of locally recurrent prostate cancer after defi nitive external beam radiation therapy.q RSNA, 2010 1

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Section: Patient Populationmentioning

confidence: 99%

Locally Recurrent Prostate Cancer after External Beam Radiation Therapy: Diagnostic Performance of 1.5-T Endorectal MR Imaging and MR Spectroscopic Imaging for Detection

Westphalen¹,

Coakley²,

Roach³

et al. 2010

Radiology

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“…[8] However, large interhospital variation in the use of radiotherapy was reported in a regional population-based study. [9] Limited data exist on differences in treatment patterns of patients with rectal cancer and to what extent these differences could be explained by differences in hospital characteristics. Several studies revealed an association between high volume and better outcome after surgery for several cancers, such as cancer of the pancreas, esophagus and lung.…”

mentioning

confidence: 99%

Variation in treatment and outcome of patients with rectal cancer by region, hospital type and volume in the Netherlands

Elferink

Krijnen

Wouters

et al. 2010

European Journal of Surgical Oncology (EJSO)

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“…Two studies found that female patients were less likely to receive preoperative RT (26,35). Variation in RT use by hospital setting, hospital volume, and surgery type was also reported by several studies (26,34,48,51,72,88). Lastly, some studies reported regional variation in RT rates (26,28).…”

Section: Initial Treatmentmentioning

confidence: 82%

“…These findings included changing trends over time and variation in rates of treatment by patient demographic and health characteristics (ie, age, gender, socioeconomic status, tumor stage, metastatic tumor status, presence of comorbidities), hospital setting and volume, and region (26,(28)(29)(30)34,(36)(37)(38)40,42,45,(46)(47)(48)55,60,61,66,68,69,72,78,79,88). Among these characteristics, patient age was one of the most consistent findings associated with treatment receipt, with older patients being less likely to receive colorectal cancer care compared with younger patients.…”

Section: Discussionmentioning

confidence: 99%

“…Studies typically reported increasing or stable rates of RT over time; for instance, one study conducted in the Netherlands found a 16% increase over the study period, with 47% receiving RT in 1998-2002 and 63% receiving RT in 2003-2006 (34). Several studies noted the declining rates of postoperative RT balanced by increasing rates of preoperative RT as a general trend over time (27,30,34,43,57,68,73,83,88). This trend was seen for patients of all age groups, although multiple studies indicated that older patients were less likely to receive either pre-or postoperative RT overall (26,28,30,34,48,78,88).…”

Section: Initial Treatmentmentioning

confidence: 99%

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Patterns of Colorectal Cancer Care in Europe, Australia, and New Zealand

et al. 2013

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Colorectal cancer is the second most common cancer in women and the third most common in men worldwide. In this study, we used MEDLINE to conduct a systematic review of existing literature published in English between 2000 and 2010 on patterns of colorectal cancer care. Specifically, this review examined 66 studies conducted in Europe, Australia, and New Zealand to assess patterns of initial care, post-diagnostic surveillance, and end-of-life care for colorectal cancer. The majority of studies in this review reported rates of initial care, and limited research examined either post-diagnostic surveillance or end-of-life care for colorectal cancer. Older colorectal cancer patients and individuals with comorbidities generally received less surgery, chemotherapy, or radiotherapy. Patients with lower socioeconomic status were less likely to receive treatment, and variations in patterns of care were observed by patient demographic and clinical characteristics, geographical location, and hospital setting. However, there was wide variability in data collection and measures, health-care systems, patient populations, and population representativeness, making direct comparisons challenging. Future research and policy efforts should emphasize increased comparability of data systems, promote data standardization, and encourage collaboration between and within European cancer registries and administrative databases.

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Population-Based Study of Trends and Variations in Radiotherapy as Part of Primary Treatment of Cancer in the Southern Netherlands Between 1988 and 2006, With an Emphasis on Breast and Rectal Cancer

Cited by 17 publications

References 54 publications

Locally Recurrent Prostate Cancer after External Beam Radiation Therapy: Diagnostic Performance of 1.5-T Endorectal MR Imaging and MR Spectroscopic Imaging for Detection

Locally Recurrent Prostate Cancer after External Beam Radiation Therapy: Diagnostic Performance of 1.5-T Endorectal MR Imaging and MR Spectroscopic Imaging for Detection

Variation in treatment and outcome of patients with rectal cancer by region, hospital type and volume in the Netherlands

Patterns of Colorectal Cancer Care in Europe, Australia, and New Zealand

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