Population distribution of high sensitivity C-reactive protein values in Aboriginal Australians: A comparison with other populations

Abstract

Objectives: To examine the distribution of C-reactive protein (CRP) values in Aboriginal Australians and its relation to age and gender. Methods: High sensitivity CRP levels were measured in 954 Aboriginal participants aged 5-74 years. Fractional polynomial regressions were used to explore the relationship between CRP and age. Results: CRP values changed with age and reached its lowest level around 10 years and then increased with age. Geometric means of CRP were 7.3 (95% confidence interval (CI): 6.6, 8.1) and 4.1 (95% CI: 3.7, 4.6) for female and male adults, respectively. Adjusting for age, the ratio of female to male CRP concentrations was 1.67 (95% CI: 1.45, 1.99) for adults, and 1.09 (95% CI: 0.84, 1.42) for children 5 to 19 years. Conclusions: CRP changes with age. Females have higher CRP values than males. CRP values in Aboriginal people are substantially higher than other populations.

C-reactive protein and the risk of developing type 2 diabetes in Aboriginal Australians

“…In addition, they also have higher CRP levels than other populations [13]. The strong and independent association between CRP and the risk of developing diabetes suggests that inflammation in may be partly responsible for the increased risk of diabetes in this population.…”

“…The distributions of CRP values vary significantly among race/ethnic groups [3] and [12]. The CRP level in Aboriginal population is much higher than that reported in other populations [13]. However, there is little information on inflammatory markers in high risk populations.…”

The independent associations of HbA1c, C-reactive protein and birth weight with cardiovascular disease, diabetes mellitus and chronic kidney disease in a remote Indigenous Australian community: a prospective cohort study

“…Aboriginal people than populations in USA, Germany, Japan, Thailand and UK and that CRP changes with age [286]. Consistent with this study, Claes et al (2014) also found that median CRP levels were higher in Indigenous Australian CKD patients than non-Indigenous Australian CKD patients [287].…”

“…This suggests the CRP and CKD association observed in our study is not exclusive to remote indigenous Australian communities. A study by Wang and Hoy in this same Indigenous community showed median CRP levels were higher than in several other international populations [286]. More recently Claes et al, in a sample of over 23,000…”

Waist circumference and risk of cardiovascular disease, type 2 diabetes and mortality among Aboriginal adults in an Australian community

“…It is a marker for inflammation as it increases in the presence of inflammation in the body. A few studies have identified high-level CRP among Aboriginal people in Australia (195,196). These studies also reported that CRP levels were higher in females than males.…”