Population structure of a vector of human diseases: <i>Aedes aegypti</i> in its ancestral range, Africa

Kotsakiozi, Panayiota; Evans, Benjamin R.; Gloria‐Soria, Andrea; Kamgang, Basile; Mayanja, Martin N.; Lutwama, Julius J.; Goff, Gilbert Le; Ayala, Diégo; Paupy, Christophe; Badolo, Athanase; Pinto, João; Sousa, Carla A.; Troco, Arlete D.; Powell, Jeffrey R.

doi:10.1002/ece3.4278

Cited by 68 publications

(124 citation statements)

References 54 publications

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“…We also sequenced 9 previously collected individuals of the human-biting domestic form from Rabai 10 , which was not present when we carried out the fieldwork for this study in 2017. Analyses of overall population structure were consistent with earlier work 6,20 . The program ADMIXTURE 21 revealed strong support for a model with three genomic clusters or ancestry components corresponding to coastal East Africa, Central/West Africa, and globally invasive human specialists ( Fig.…”

Section: Preference For Humans Within and Outside Africa Has A Singlesupporting

confidence: 84%

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Climate and urbanization drive mosquito preference for humans

Rose

Sylla

Badolo³

et al. 2020

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The majority of mosquito-borne illness is spread by a few mosquito species that have evolved to specialize in biting humans, yet the precise causes of this behavioral shift are poorly understood. We address this gap in the arboviral vector Aedes aegypti . We first characterize the behaviour of mosquitoes from 27 sites scattered across the species' ancestral range in sub-Saharan Africa, revealing previously unrecognized diversity in female preference for human versus animal odor. We then use modelling to show that this diversity can be almost fully predicted by two ecological factors -dry season intensity and human population density. Finally we integrate this information with whole genome sequence data from 345 individual mosquitoes to identify a single underlying ancestry component linked to human preference, with genetic changes concentrated in a few key chromosomal regions. Our findings strongly suggest that human-biting in this important disease vector originally evolved as a by-product of breeding in human-stored water in areas where doing so provided the only means to survive the long, hot dry season. Our model also predicts that changes in human population density are likely to drive future mosquito evolution. Rapid urbanization may drive a shift to human-biting in many cities across Africa by 2050.

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Section: Preference For Humans Within and Outside Africa Has A Singlesupporting

confidence: 84%

“…Host-seeking females take up to 95% of their blood meals from humans in nature 3 . This human-biting specialist is thought to have evolved from generalist ancestors in Africa approximately 5,000-10,000 years ago, possibly in northern Senegal or Angola 6,7 . However, in at least a few places in East Africa, the contemporary African subspecies Ae.…”

mentioning

confidence: 99%

Climate and urbanization drive mosquito preference for humans

Rose

Sylla

Badolo³

et al. 2020

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“…FastStructure analysis revealed that the number of model components and model maximum likelihood were maximised by assigning each individual to between K4-6 populations. Similar to that reported previously, we find that the new world variation is composed of an admixture of populations distinct from African and Asian sources at higher values of K (19,20). Individuals from Panama, Costa Rica, Colombia, the Caribbean islands and populations from Arizona and Texas in South western USA were consistently composed of a similar composition throughout each possible value of K (SI Appendix Fig S1).…”

Section: Resultssupporting

confidence: 87%

“…Comparison of global population structure was achieved by comparing a subset of 2,630 of our SNP's from Panama that were shared with a previously acquired Ae. aegypti SNP dataset from 26 other countries worldwide (19)(20)(21)(22)(23). FastStructure analysis revealed that the number of model components and model maximum likelihood were maximised by assigning each individual to between K4-6 populations.…”

Section: Resultsmentioning

confidence: 99%

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The impact of biological invasion and genomic local adaptation on the geographical distribution of Aedes aegypti in Panama

Bennett¹,

McMillan²,

Loaiza

2019

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Local adaptation is an important consideration when predicting arthropod-borne disease risk because it can impact on individual vector fitness and vector population persistence. However, the extent that populations are adapted to local environmental conditions remains unknown. Here, we identified 128 candidate SNPs, clustered within 17 genes, which show a strong genetic signal of adaptation across Panama. Analysis of genome-wide SNPs showed that the local adaptation of Aedes aegypti mosquito populations occurs across relatively fine geographic scales. The composition and frequency of candidate adaptive loci differed between populations in wet tropical environments along the Caribbean coast and the dry tropical conditions typical of the Pacific coast of Panama. Temperature and vegetation were important predictors of adaptive genomic variation in Ae. aegypti with areas of local adaptation occurring within the Caribbean region of Bocas del Toro, the Pacific coastal areas of Herrera and Panama City and the eastern Azuero Peninsula. In addition, we found that the geographic distribution of Ae. aegypti across Panama is rapidly changing as a consequence of the recent invasion by its ecological competitor, Aedes albopictus. Although Ae. albopictus has displaced Ae. aegypti in some areas, species coexist across many areas, including regions where Ae. aegypti are locally adapted. Our results guide future experimental work by suggesting that adaptive variation within Ae. aegypti is affecting the outcome of inter-specific competition with Ae. albopictus and, as a consequence, may fundamentally alter future arborviral disease risk and efforts to control mosquito populations.

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Population structure of a vector of human diseases: Aedes aegypti in its ancestral range, Africa

Kotsakiozi

Evans

Gloria‐Soria

et al. 2018

Ecology and Evolution

113

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Aedes aegypti, the major vector of dengue, yellow fever, chikungunya, and Zika viruses, remains of great medical and public health concern. There is little doubt that the ancestral home of the species is Africa. This mosquito invaded the New World 400‐500 years ago and later, Asia. However, little is known about the genetic structure and history of Ae. aegypti across Africa, as well as the possible origin(s) of the New World invasion. Here, we use ~17,000 genome‐wide single nucleotide polymorphisms (SNPs) to characterize a heretofore undocumented complex picture of this mosquito across its ancestral range in Africa. We find signatures of human‐assisted migrations, connectivity across long distances in sylvan populations, and of local admixture between domestic and sylvan populations. Finally, through a phylogenetic analysis combined with the genetic structure analyses, we suggest West Africa and especially Angola as the source of the New World's invasion, a scenario that fits well with the historic record of 16th‐century slave trade between Africa and Americas.

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Population structure of a vector of human diseases: Aedes aegypti in its ancestral range, Africa

Cited by 68 publications

References 54 publications

Climate and urbanization drive mosquito preference for humans

Climate and urbanization drive mosquito preference for humans

The impact of biological invasion and genomic local adaptation on the geographical distribution of Aedes aegypti in Panama

Population structure of a vector of human diseases: Aedes aegypti in its ancestral range, Africa

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