Populeuphrines A and B, two new cembrane diterpenoids from the resins of <i>Populus euphratica</i>

Liu, Kaixin; Qin, Da-Peng; Zhu, Yanxia; Wang, Shaoxiang; Ge, Peng-Ling; Cheng, Yong‐Xian

doi:10.1080/14786419.2019.1610753

Cited by 7 publications

(5 citation statements)

References 20 publications

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“…The phenolic glycoside pathway is not fully characterized. However, several studies have shown that phenolic glycosides (PGs) are descended from cinnamic acid, involved in the shikimate-phenylpropanoid pathway, and made in the catalytic reaction phenylalanine and PAL [25]. Furthermore, PAL is inhibited by 2-aminoindan-2-phosphonic acid in the reaction above, reducing cinnamic acid production [47,48].…”

Section: Phenolic Glycosidesmentioning

confidence: 99%

Plant Secondary Metabolites with an Overview of Populus

Movahedi

Yaghuti

Wei

et al. 2021

IJMS

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Populus trees meet continuous difficulties from the environment through their life cycle. To warrant their durability and generation, Populus trees exhibit various types of defenses, including the production of secondary metabolites. Syntheses derived from the shikimate-phenylpropanoid pathway are a varied and plentiful class of secondary metabolites manufactured in Populus. Amongst other main classes of secondary metabolites in Populus are fatty acid and terpenoid-derivatives. Many of the secondary metabolites made by Populus trees have been functionally described. Any others have been associated with particular ecological or biological processes, such as resistance against pests and microbial pathogens or acclimatization to abiotic stresses. Still, the functions of many Populus secondary metabolites are incompletely understood. Furthermore, many secondary metabolites have therapeutic effects, leading to more studies of secondary metabolites and their biosynthesis. This paper reviews the biosynthetic pathways and therapeutic impacts of secondary metabolites in Populus using a genomics approach. Compared with bacteria, fewer known pathways produce secondary metabolites in Populus despite P. trichocarpa having had its genome sequenced.

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Section: Phenolic Glycosidesmentioning

confidence: 99%

Plant Secondary Metabolites with an Overview of Populus

Movahedi

Yaghuti

Wei

et al. 2021

IJMS

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“…In this present research, the inhibitory activity of the Populus euphratica extract on the oral cancer treatment was evaluated with Cell Counting Kit-8 assay. This preformation was conducted strictly under the guidance of the instructions with some modifications for the viability evaluation of the oral cancer cells after treated with the Populus euphratica extract 12 . In brief, the oral cancer cells in the logical growth phage were collected and seeded into the 96 well plates at the final destiny of 10 4 cells per well.…”

Section: Cck-8 Assaymentioning

confidence: 99%

Anti-oral Cancer Biological Activity Evaluation and Chloroplast Genome Analyses of <i>Populus euphratica</i>

Wang

Yang²

2021

J. Oleo Sci.

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IntroductionOral cancer is the malignant tumors that occur in the oral cavity, including tongue cancer, gum cancer, buccal mucosal cancer, lip cancer, and jaw cancer 1, 2 . Oral cancer is the fourth cause of death and the number of cancer deaths among male Chinese. Smoking will greatly increase the incidence of oral cancer. The treatment of oral cancer has achieved great advances. However, up to now, only a small number of patients could be totally cured, and the final outcome of most patients is still not optimistic. The recurrence and metastasis of malignant tumors is still the biggest risk 3 . In 1999, Tubiana reported that 45 of cancer patients could be thoroughly cured. Over the past ten years, a lot of progress has been made, and at present, nearly 50 of malignant tumor patients can survive for more than 5 years, indicating more than half are still of malignant tumor patients cannot be cured. The surgery, radiation, chemotherapy, and immunotherapy were the common therapy method for the cancer treatment, which could sig- § Authors are contributed equally to this work.

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“…As a result, an increasing number of structurally novel terpenoids have been characterized [5,6,7]. In a continuous study on medicinal resins, the title material was investigated, resulting in the isolation of diterpenoids with cytotoxic and potent wound-healing promotion properties [8,9,10]. The current work is an in-depth investigation on P. euphratica resins, which led to the characterization of 12 terpenoids and one steroid with euphraticanoid compounds A–D ( 1 – 4 ) being new ones (Figure 1).…”

Section: Introductionmentioning

confidence: 99%

Neuroprotective Norsesquiterpenoids and Triterpenoids from Populus euphratica Resins

et al. 2019

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Two new octanorlanostane-type triterpenes, euphraticanoids A and B (1 and 2), two new trinorsesquiterpenoids, euphraticanoids C and D (3 and 4), and eight known triterpenoids (5, 6, 8–13) along with one steroid (7) were isolated from Populus euphratica resins. The structures of these new compounds, including their absolute configurations, were characterized by spectrocsopic, chemical, and computational methods. Biological evaluation revealed that compounds 4, 7–9, 12, and 13 display neuroprotective activities in H2O2-induced HT-22 cells with 4, 8, and 9 occurring in a concentration-dependent manner and 7, 12, and 13 reaching the maximum effects at 20 μM. Meanwhile, the neuroprotective properties of all isolates were accessed using glutamate-induced SH-SY5Y cells and disclosed that compounds 3, 4, 8, and 9 could dose-dependently protect neural cell injury in a concentration range of 10–40 μM. Finally, a brief structure–activity relationship was briefly discussed.

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Populeuphrines A and B, two new cembrane diterpenoids from the resins of Populus euphratica

Cited by 7 publications

References 20 publications

Plant Secondary Metabolites with an Overview of Populus

Plant Secondary Metabolites with an Overview of Populus

Anti-oral Cancer Biological Activity Evaluation and Chloroplast Genome Analyses of <i>Populus euphratica</i>

Neuroprotective Norsesquiterpenoids and Triterpenoids from Populus euphratica Resins

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