Popymorphism of Immune Response Genes and Lung Cancer Risk in Non-Smoking Residents of Kuzbass

Abstract

Lung cancer (LC) is leading oncological pathology, posing a serious threat for patient’s lives.
 Accordingly to World Health Organization (WHO) 2,1 million of new cases and 1,8 of deaths are
 annually registered. It was accumulated a lot of information about significant influence of smoking on
 increased risk of LC development. 80-90% of patients with LC are namely smokers. However at present
 time it was registered increased level of mortality from this pathology among non-smoking patients [1].
 LC formation in non-smoking individuals can occur due to environmental pollution by industrial and
 household cancerogens and also because of molecular and genetical and cytogenetical dissimilarities.
 Since LC development can be associated with anomalous immunological response, immune genes can
 be considered as potential biological markers [2].
 Objective: To assess the influence of polymorphic variants of innate immunity genes on LC
 development in non-smoking patients.