Pore size and pore shape – but not mesh density – alter the mechanical strength of tissue ingrowth and host tissue response to synthetic mesh materials in a porcine model of ventral hernia repair

Lake, Spencer P.; Ray, Shuddhadeb; Zihni, Ahmed M.; Thompson, Dominic M.; Gluckstein, Jeffrey; Deeken, Corey R.

doi:10.1016/j.jmbbm.2014.11.011

Cited by 72 publications

(44 citation statements)

References 20 publications

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“…Several fundamental experiments and clinical studies have already demonstrated that external support could efficiently prevent the dilation of venous walls and inhibit IH [10–12, 16, 18, 20, 21]. The external stent material used in previous experiments was easy to cause inflammation, foreign body reaction, and even fibrosis [22], which may be consistent with IH process. Because of the good biocompatibility, high permeability, and favorable biodegradability, collagen has been widely used in tissue engineering [13–15].…”

Section: Discussionmentioning

confidence: 99%

Collagen External Scaffolds Mitigate Intimal Hyperplasia and Improve Remodeling of Vein Grafts in a Rabbit Arteriovenous Graft Model

Chai

Dai

et al. 2017

BioMed Research International

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Objectives. The aim of this study was to test the effects of collagen external scaffold (CES) in intimal hyperplasia of vein grafts and explore its underlying mechanisms. Methods. Thirty-six New Zealand white rabbits were randomized into no-graft group, graft group, and CES group. The rabbit arteriovenous graft model was established. In CES group, the vein graft was wrapped around with CES. The hemodynamic parameters of vein grafts were measured intraoperatively and 4 weeks after operation by ultrasonic examination. Histological characteristics of vein grafts were also evaluated 4 weeks later. The mRNA and protein levels of proliferating cell nuclear antigen (PCNA), active cleaved-caspase-3 (ClvCasp-3), and smooth muscle 22 alpha (SM22α) were measured 4 weeks later by quantitative real-time PCR and western blot. Results. CES significantly improved the hemodynamic stability of vein grafts, with higher blood velocity and blood flow. Similarly, CES also markedly mitigated intimal hyperplasia and inhibited dilatation of vein grafts. In CES group, the upexpression of PCNA and ClvCasp-3 and the downexpression of SM22α were inhibited. Conclusion. CES exerts beneficial effects in mitigating intimal hyperplasia and improving remodeling of autogenous vein grafts, which may be associated with reducing the proliferation and apoptosis and preserving the phenotype of VSMCs.

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Section: Discussionmentioning

confidence: 99%

Collagen External Scaffolds Mitigate Intimal Hyperplasia and Improve Remodeling of Vein Grafts in a Rabbit Arteriovenous Graft Model

Chai

Dai

et al. 2017

BioMed Research International

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“…It goes without saying that, depending on the material, surgical meshes may have varying susceptibility to either MPO or ROS. Even mesh design may play a role in the susceptibility of a mesh to deterioration . A number of recent studies showed that effect of the oxidative stress on hernia repair meshes made of the same material can be different, resulting in different complication rates .…”

Section: Introductionmentioning

confidence: 99%

In vitro study on the deterioration of polypropylene hernia repair meshes

et al. 2017

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Despite the relative safety of the procedure, hernia repairs are often associated with chronic post-operative pain. Although this complication has been linked among others to mesh deterioration, details of the processes that lead this deterioration are still unknown. This work aims to bridge this gap by analyzing the chemical, physical and structural alterations in hernia repair meshes exposed to oxidative stress in vitro. Here, we developed a methodology to characterize effect of oxidation stress on structure and properties of polymeric hernia repair meshes. It was shown that structural changes in polypropylene meshes exposed to oxidative stress may involve formation of cross-links between the polymer chains, chain scissions, and hydrogen bonds between the carboxyl groups, which are formed in the material during the oxidation. These effects result in mesh stiffening, ultimately leading to chronic post-operative pain. Moreover, we demonstrated that Composix meshes are more vulnerable to the oxidative stress when compared with UltraPro meshes. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 2225-2234, 2018.

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“…The mesh material used was slightly different in some of the studies, and one study used different mesh in each group. Another study reported that different meshes could have different effects on integration and tissue ingrowth, but this was not taken into consideration in the present review. Closure of the fascial defect was described in only four of the included studies, but its effect on recurrence is not fully clarified.…”

Section: Discussionmentioning

confidence: 95%

Systematic review and network meta-analysis of methods of mesh fixation during laparoscopic ventral hernia repair

Baker

Öberg

Andresen

et al. 2018

Journal of British Surgery

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Pore size and pore shape – but not mesh density – alter the mechanical strength of tissue ingrowth and host tissue response to synthetic mesh materials in a porcine model of ventral hernia repair

Cited by 72 publications

References 20 publications

Collagen External Scaffolds Mitigate Intimal Hyperplasia and Improve Remodeling of Vein Grafts in a Rabbit Arteriovenous Graft Model

Collagen External Scaffolds Mitigate Intimal Hyperplasia and Improve Remodeling of Vein Grafts in a Rabbit Arteriovenous Graft Model

In vitro study on the deterioration of polypropylene hernia repair meshes

Systematic review and network meta-analysis of methods of mesh fixation during laparoscopic ventral hernia repair

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