Pore structures in an implantable sol–gel titania ceramic device used in controlled drug release applications: A modeling study

Peterson, Aaron; López, T.; Islas, E. Ortiz; Gonzalez, Richard

doi:10.1016/j.apsusc.2006.12.094

Cited by 23 publications

(26 citation statements)

References 8 publications

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“…The reference samples (the samples synthesized in the same way but without the drug) did not express this unusual feature either, which allowed us to conclude that the reason of the results above is the pore structuring produced by phenytoin during the sol-gel synthesis resulting in the adsorbent trapping. Indeed, it was shown by Peterson et al 15 that such a structuring may take place for similar systems.…”

Section: Resultsmentioning

confidence: 95%

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Influence of Water/Alkoxide Ratio in the Synthesis of Nanosized Sol−Gel Titania on the Release of Phenytoin

et al. 2011

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The sol-gel method was used to synthesize inorganic reservoirs with encapsulated antiepileptic drug phenytoin. The drug release profile was shown to depend on the morphology and surface properties of the matrix. A parameter of the synthesis such as water/alkoxide ratio r(w) was varied in order to investigate its influence on the matrix properties and as a result on the drug release profile. It was found that the specific surface area and crystallization degree decrease with an increase of r(w), whereas the hydroxyl group coverage increases with an increase of r(w). Drug release kinetics studies revealed that the initial release rate increases with an increase of water content in the reaction, whereas the long time release rate first slightly increases with an increase of water content from 4 to 8 and then decreases for r(w) = 16. The interplay of different parameters of the matrix is shown to be responsible for such a dependence and is discussed in the Article.

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Section: Resultsmentioning

confidence: 95%

“…10,[13][14][15][16] Since the majority of these factors may be controlled by the parameters of the sol-gel synthesis, the drug release kinetics, therefore, may be tuned by tailoring the processing parameters during the sol-gel reaction. [17][18][19][20][21][22][23] One of the parameters to control is the water/alkoxide ratio r w .…”

Section: Introductionmentioning

confidence: 99%

Influence of Water/Alkoxide Ratio in the Synthesis of Nanosized Sol−Gel Titania on the Release of Phenytoin

et al. 2011

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“…În gelurile astfel sintetizate, s-au înglobat lidocaină şi bupivacaină. Pentru analiza eliberării de anestezice sau realizat sisteme artificiale in vitro, la care s-a variat temperatura (30°C, 36.5°C, 40°C) şi pH-ul (6,7,8).…”

Section: Discussionunclassified

“…Two parameters were varied: temperature (30°C, 36.5°C, 40°C) and pH (6,7,8). Thus, nine systems of artificially controlled release were obtained in which the variables, temperature and pH, were combined.…”

Section: Resultsmentioning

confidence: 99%

“…Currently, these materials are studied as potential systems for the controlled release of biologically active compounds, because of their basic characteristics, among which we mention the porosity of the matrix, bioavailability and biodegradability. They are synthetized under normal temperature and pressure conditions and silica gels are approved by the Food and Drug Administration (FDA) [7,8], being equally DOI: http://dx.doi.org/10.21454/rjaic.7518/232.vit tolerated by the human organism in oral, interstitial or topical administration. Porous silica gels are obtained by condensation and polycondensation of hydroxylated units obtained through the hydrolysis of some precursors [9,10].…”

Section: Introductionmentioning

confidence: 99%

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An in vitro study of the release capacity of the local anaesthetics from siloxane matrices

Preda

Rogobete

Săndesc

et al. 2016

Rom J Anaesth Int Care

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Aims. In the field of anaesthesia and intensive care, the controlled release systems capable of delivering constantly local anaesthetics are of interest because of the advantages brought to pain management. In this paper we presented the release profiles by usage of siloxane matrices of two common local anaesthetics, lidocaine and bupivacaine, analysed in vitro.Methods. The siloxane matrices were obtained in accordance with the methods described in the specialized literature, tetraethoxysilane (TEOS) and tetramethoxysilane (TMOS) were used as precursors. Lidocaine and bupivacaine were encapsulated in the synthesized gels. The controlled release was performed in vitro artificial systems in which temperature (30°C, 36.5°C, 40°C) and pH (6, 7, 8) have varied.Results. Following the analysis of the artificial systems similar profiles were highlighted for both local anaesthetics. Statistically significant differences were identified (p < 0.05) for systems where the release occurred at temperatures above 36.5°C. There were no statistically significant differences regarding the influence of pH, the type of the entrapped anaesthetic or the type of the precursor used in the synthesis of siloxane matrices.Conclusions. According to this experimental study, the pH, the type of precursor or the type of anaesthetic does not statistically influence the release profile from the studied system. In conclusion, these systems are promising for obtaining pharmaceutical preparations which can be used in current clinical practice. Several studies on controlled release siloxane systems should be carried out both in vitro and in vivo in order to exclude possible toxicity and histopathological effects.

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Structure‐Directing Agents for the Synthesis of TiO₂‐Based Drug‐Delivery Systems

Ghedini

Nichele

Signoretto

et al. 2012

Chemistry A European J

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A series of titanium oxides was prepared by using a surfactant-template method (STM) and used as a carrier for the sustained release of ibuprofen, which was chosen as a model drug. This STM provides an efficient route to TiO(2) matrices with both high surface area (when compared with those that were obtained by using traditional synthetic approaches) and well-defined mesoporous textures. Some parameters of the synthetic procedure were varied: pH value, surfactant, and thermal treatment. The physicochemical nature of the surface carriers were investigated by means of N(2) -physisorption measurements and FTIR spectroscopy. The effect of the amount of drug on the release kinetics was also investigated. The drug delivery was evaluated in vitro in four different physiological solutions (that simulated the gastrointestinal tract) to analyze the behavior of the TiO(2) -based systems if they were to be formulated as oral DDSs. Our optimized approach is a good alternative to the classical methods that are used to prepare efficient TiO(2) -based drug-delivery systems.

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Pore structures in an implantable sol–gel titania ceramic device used in controlled drug release applications: A modeling study

Cited by 23 publications

References 8 publications

Influence of Water/Alkoxide Ratio in the Synthesis of Nanosized Sol−Gel Titania on the Release of Phenytoin

Influence of Water/Alkoxide Ratio in the Synthesis of Nanosized Sol−Gel Titania on the Release of Phenytoin

An in vitro study of the release capacity of the local anaesthetics from siloxane matrices

Structure‐Directing Agents for the Synthesis of TiO₂‐Based Drug‐Delivery Systems

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Pore structures in an implantable sol–gel titania ceramic device used in controlled drug release applications: A modeling study

Cited by 23 publications

References 8 publications

Influence of Water/Alkoxide Ratio in the Synthesis of Nanosized Sol−Gel Titania on the Release of Phenytoin

Influence of Water/Alkoxide Ratio in the Synthesis of Nanosized Sol−Gel Titania on the Release of Phenytoin

An in vitro study of the release capacity of the local anaesthetics from siloxane matrices

Structure‐Directing Agents for the Synthesis of TiO2‐Based Drug‐Delivery Systems

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Structure‐Directing Agents for the Synthesis of TiO₂‐Based Drug‐Delivery Systems