Porous capillary monolithic column coupled with ultrahigh performance liquid chromatography-tandem mass spectrometry for fast and effective separation and determination of estrogens

Yang, Yanqun; Huang, Yipeng; Wu, Zhuqiang; Shi, Rui; Chen, Zhengyi; Ruan, Guihua

doi:10.1016/j.aca.2022.340270

Cited by 17 publications

(9 citation statements)

References 39 publications

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“…The external standard quantitative method was used to analyze ZEN and ZAN. The enrichment factors ( EFs ) were calculated based on the following Equation () [23].

\begin{equation}EFs = \frac{{{A}_1}}{{{A}_0}}\ \end{equation}

where A 0 and A 1 are the peak areas of the standard solution without extraction and after extraction.…”

Section: Methodsmentioning

confidence: 99%

“…The external standard quantitative method was used to analyze ZEN and ZAN. The enrichment factors (EFs) were calculated based on the following Equation (3) [23].…”

Section: Uhplc-ms/ms Analysismentioning

confidence: 99%

“…To accurately describe the adsorption process and binding properties of polyHIPEs-CNT-COOH for the analytes, the adsorption isotherm data were fitted using Langmuir (Equation ( 4)) and Freundlich (Equation ( 5)) models [23,26]. Scatchard analysis (Equation ( 6)) was used to evaluate the types of theoretical binding sites [27].…”

Section: Adsorption Mechanism For Zen and Zan Enrichmentmentioning

confidence: 99%

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Amphiphilic polymers facilitated solid‐phase extraction coupled with ultra‐performance liquid chromatography‐tandem mass spectrometry for direct extraction and analysis of zearalenone and zearalanone in corn juice samples

Jiang

Yang

et al. 2023

J of Separation Science

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In this work, amphiphilic polymers synthesized from carboxylated carbon nanotubes stabilized high internal phase emulsions are demonstrated to be capable of direct extracting zearalenone and zearalanone in samples consisting of an oil‐water emulsion system. Under optimal conditions, the maximum adsorption capacities for zearalenone and zearalanone are 17.27 and 13.26 mg/g. The adsorption is mainly attributed to π‐π interaction, hydrophobic interaction, and hydrogen‐bonding interaction for zearalenone and zearalanone. The adsorption isotherms reveal that the adsorption of zearalenone and zearalanone on amphiphilic polymers synthesized from carboxylated carbon nanotubes stabilized high internal phase emulsions follows Freundlich model with multilayer and heterogeneous adsorption due to the presence of multiple kinds of adsorption sites. The relative recoveries of the spiked zearalenone and zearalanone in corn juice samples range from 85% to 93% with relative standard deviations lower than 3.52%. The results manifest the high efficiency of amphiphilic polymers synthesized from carboxylated carbon nanotubes stabilized high internal phase emulsions for the adsorption and separation of analytes in the oil‐water emulsion system. This study provides a new perspective on adsorbent engineering for the adsorption application in heterogeneous media.

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“…The external standard quantitative method was used to analyze ZEN and ZAN. The enrichment factors ( EFs ) were calculated based on the following Equation () [23].

\begin{equation}EFs = \frac{{{A}_1}}{{{A}_0}}\ \end{equation}

where A 0 and A 1 are the peak areas of the standard solution without extraction and after extraction.…”

Section: Methodsmentioning

confidence: 99%

“…The external standard quantitative method was used to analyze ZEN and ZAN. The enrichment factors (EFs) were calculated based on the following Equation (3) [23].…”

Section: Uhplc-ms/ms Analysismentioning

confidence: 99%

Section: Adsorption Mechanism For Zen and Zan Enrichmentmentioning

confidence: 99%

See 1 more Smart Citation

Amphiphilic polymers facilitated solid‐phase extraction coupled with ultra‐performance liquid chromatography‐tandem mass spectrometry for direct extraction and analysis of zearalenone and zearalanone in corn juice samples

Jiang

Yang

et al. 2023

J of Separation Science

Self Cite

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“…For instance, a porous capillary monolith was prepared for the extraction of eight estrogens from serum, urine, water, and soil. 30 MIP was used for the extraction of six estrogenic compounds from milk. 31 Additionally, a poly(methacrylic acid/3-acrylamidophenylboronic acid-co-ethylene glycol dimethacrylate) monolith was used for extraction of six estrogens from urine and serum; 32 these reports are significant as they demonstrate the feasibility of sample preparation, including complex biofluids as serum, through IT-SPME.…”

mentioning

confidence: 99%

“…Applications to serum or plasma are offline. For instance, a porous capillary monolith was prepared for the extraction of eight estrogens from serum, urine, water, and soil . MIP was used for the extraction of six estrogenic compounds from milk .…”

mentioning

confidence: 99%

Preparation of Monolith for Online Extraction and LC–MS Analysis of β-Estradiol in Serum Via a Simple Multicomponent Reaction

Cerrato,

Aita,

Cavaliere

et al. 2024

Anal. Chem.

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Multicomponent reactions offer efficient and environmentally friendly strategies for preparing monoliths suitable for applications in analytical chemistry. In the described study, a multicomponent reaction was utilized for the one-pot miniaturized preparation of a poly(propargyl amine) polymer inside commercial silica-lined PEEK tubing. The reaction involved only small amounts of reagents and was characterized by atom economy. The resulting monolithic column was incorporated into an autosampler system for the online extraction and cleanup of β-estradiol from human serum. Sample pretreatment was simplified to a simple dilution with methanol and centrifugation to remove proteins. The resulting platform included LC−MS analysis in multiple reaction monitoring for quantitative analysis of β-estradiol. The method was validated in serum, demonstrating practical applicability for the monitoring of fertile women. Recoveries were above 94%, and LOD and LOQ values at 0.008 and 0.18 ng mL −1 , respectively. The developed platform proved to be competitive with previous methods for solidphase microextraction of β-estradiol in serum, with comparable recovery and sensitivity but with the advantage of nearly complete automation. The environmental impact of the process was evaluated as acceptable due to the miniaturization of the monolith synthesis and the automation of extraction. The drawback associated with the LC−MS technique can be reduced by the inclusion of additional analytes in a single investigation. The work demonstrates that multicomponent reactions are versatile, economical, and possibly a green methodology for producing reversed-phase and mixed-mode sorbents, enabling miniaturization of the entire analytical procedure from the preparation of extraction sorbents to analysis.

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Liquid chromatography-mass spectrometry

Picó,

Barceló

2025

Sample Handling and Trace Analysis of Pollutants

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Porous capillary monolithic column coupled with ultrahigh performance liquid chromatography-tandem mass spectrometry for fast and effective separation and determination of estrogens

Cited by 17 publications

References 39 publications

Amphiphilic polymers facilitated solid‐phase extraction coupled with ultra‐performance liquid chromatography‐tandem mass spectrometry for direct extraction and analysis of zearalenone and zearalanone in corn juice samples

Amphiphilic polymers facilitated solid‐phase extraction coupled with ultra‐performance liquid chromatography‐tandem mass spectrometry for direct extraction and analysis of zearalenone and zearalanone in corn juice samples

Preparation of Monolith for Online Extraction and LC–MS Analysis of β-Estradiol in Serum Via a Simple Multicomponent Reaction

Liquid chromatography-mass spectrometry

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