Porous ceramic bone scaffolds for vascularized bone tissue regeneration

Will, J.; Melcher, Reinhold; Treul, Cornelia; Travitzky, Nahum; Kneser, Ulrich; Polykandriotis, Elias; Horch, Raymund E.; Greil, Peter

doi:10.1007/s10856-007-3346-5

Cited by 144 publications

(81 citation statements)

References 46 publications

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“…Porous ceramics are also promising materials for medical use as osteoplastic material or as 3D scaffold for tissue engineered bone equivalent modeling [4].…”

Section: Introductionmentioning

confidence: 99%

Rheology and porosity effect on mechanical properties of zirconia ceramics

Kulkov¹,

Buyakova²,

Chatzinikolaidou³

et al. 2015

Epitoanyag - JSBCM

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Porous ceramics obtained from ultra-fine powders have been studied. the porosity of ceramic samples was found between 15 to 80 %. the structure of the ceramic materials was a cellular structure. A distinctive feature of all the deformation diagrams obtained in the experiment was their nonlinearity at low deformations which was described by parabolic law. it was shown that the observed nonlinear elasticity for low deformations on deformation diagrams is due to mechanical instability of the cellular elements in the ceramic carcass.

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“…Porous ceramics are also promising materials for medical use as osteoplastic material or as 3D scaffold for tissue engineered bone equivalent modeling [4].…”

Section: Introductionmentioning

confidence: 99%

Rheology and porosity effect on mechanical properties of zirconia ceramics

Kulkov¹,

Buyakova²,

Chatzinikolaidou³

et al. 2015

Epitoanyag - JSBCM

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“…Particle systems or scaffolds that persist in the wound, in some cases, may even hinder formation of cohesive, mechanically competent bone that also recapitulates geometry (27). The time taken to induce repair is significantly longer, and the reported bone strength with these permanent systems is often lower than native bone (28). Our studies suggest that the release of specific known growth factors, BMP-2 and PDGF-BB, either individually or in combination, is critical to enhanced bone regeneration.…”

Section: Discussionmentioning

confidence: 99%

Adaptive growth factor delivery from a polyelectrolyte coating promotes synergistic bone tissue repair and reconstruction

Shah

Hyder

Quadir

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

131

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Traumatic wounds and congenital defects that require large-scale bone tissue repair have few successful clinical therapies, particularly for craniomaxillofacial defects. Although bioactive materials have demonstrated alternative approaches to tissue repair, an optimized materials system for reproducible, safe, and targeted repair remains elusive. We hypothesized that controlled, rapid bone formation in large, critical-size defects could be induced by simultaneously delivering multiple biological growth factors to the site of the wound. Here, we report an approach for bone repair using a polyelectrolye multilayer coating carrying as little as 200 ng of bone morphogenetic protein-2 and platelet-derived growth factor-BB that were eluted over readily adapted time scales to induce rapid bone repair. Based on electrostatic interactions between the polymer multilayers and growth factors alone, we sustained mitogenic and osteogenic signals with these growth factors in an easily tunable and controlled manner to direct endogenous cell function. To prove the role of this adaptive release system, we applied the polyelectrolyte coating on a well-studied biodegradable poly(lactic-co-glycolic acid) support membrane. The released growth factors directed cellular processes to induce bone repair in a critical-size rat calvaria model. The released growth factors promoted local bone formation that bridged a critical-size defect in the calvaria as early as 2 wk after implantation. Mature, mechanically competent bone regenerated the native calvaria form. Such an approach could be clinically useful and has significant benefits as a synthetic, off-the-shelf, cell-free option for bone tissue repair and restoration.regenerative medicine | layer-by-layer | biomaterial | controlled drug release | wound healing

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“…In general, scaffolds serve as basis component for the repair of bone defects. Three-dimensional printing allows manufacturing those scaffolds with defined and reproducible internal structures directly from computed-tomography (CT) data [3][4][5][6][7] . Tissue engineering (TE) is highly important for bone repair, so that repair of damaged and diseased tissue is the principal goal of all tissue engineering efforts 8,9) .…”

Section: Introductionmentioning

confidence: 99%

Mechanical and biological effects of infiltration with biopolymers on 3D printed tricalciumphosphate scaffolds

Cornelsen

Probst²,

Schwarz³

et al. 2017

Dent. Mater. J.

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The aim of this study was to evaluate the influence of infiltrating 3D printed (TCP) scaffolds with different biodegradable polymers on their mechanical and biological properties. 3D printed TCP scaffolds with interconnecting channels measuring 450±50 µm were infiltrated with four different biodegradable copolymers. To determine the average compressive strength, a uniaxial testing system was used. Additionally, scaffolds were seeded with MC3T3 cells and cell viability was assessed by live/dead-assay. Uninfiltrated TCP had an average compression strength of 1.92±0.38 MPa. Mechanical stability was considerably increased in all infiltrated scaffolds up to a maximum of 7.36±0.57 MPa. All scaffolds demonstrated high cell survival rates with a maximum of 94±10 % living cells. In conclusion, infiltration of 3D printed tricalcium phosphate scaffolds with biodegradable polymers significantly improved mechanical properties and biological properties were comparable to those of uninfiltrated TCP scaffolds.

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Porous ceramic bone scaffolds for vascularized bone tissue regeneration

Cited by 144 publications

References 46 publications

Rheology and porosity effect on mechanical properties of zirconia ceramics

Rheology and porosity effect on mechanical properties of zirconia ceramics

Adaptive growth factor delivery from a polyelectrolyte coating promotes synergistic bone tissue repair and reconstruction

Mechanical and biological effects of infiltration with biopolymers on 3D printed tricalciumphosphate scaffolds

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