Porous Coated Titanium Implants do Not Inhibit Mesenchimal Stem Cells Proliferation and Osteogenic Differentiation

TI-6AL-4V alloy and β-tricalcium phosphate-based systems for in vitro study of mesenchymal stem cell functions at implant–tissue interface

“…By using well-characterized, clinically approved and commercially available biomaterials such as Ti-6Al-4V alloy and b-TCP, which are commonly used for the production of arthroplasty prostheses, we demonstrated an easily reproducible and methodologically accessible in vitro system for studying MSC functions at the bone-implant interface. On the basis of our current and previous [38] results it can be concluded that both Ti-6Al-4V alloy and b-TCP surfaces provide favourable conditions for the proliferation and multilineage differentiation of bone marrow MSC, and are suitable for use in in vitro models for the study of MSC functions at the bone-implant contact zone.…”