Porous composite prosthetic pylon for integration with skin and bone

Pitkin, Mark R.; Raykhtsaum, Grigory; Pilling, John; Galibin, Оleg V.; Protasov, Mikhail V.; Chihovskaya, Julie V.; Belyaeva, Irina G.; Блинова, М. И.; Yudintceva, Natalia; Potokin, I. L.; Пинаев, Г. П.; Moxson, Vladimir; Duz, Volodimir

doi:10.1682/jrrd.2006.12.0160

Cited by 23 publications

(43 citation statements)

References 39 publications

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“…6 ). The cross section of the pylon clearly demonstrated the ingrowth of the soft tissues into the pores of the titanium, that was similar in nature to our previous experiments with non modified pylons [22, 45, 46]. With the non modified pylons (control), following 6 months after surgery we observed the patchy fibrovascular ingrowth ( Fig.…”

Section: Discussionsupporting

confidence: 85%

Application of the skin and bone integrated pylon with titanium oxide nanotubes and seeded with dermal fibroblasts

Shevtsov

Yudintceva

Блинова

et al. 2015

Prosthetics &Amp; Orthotics International

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Study Design The feasibility and safety of in bone implantation of the skin and bone integrated pylons (SBIP) with nanotubes was investigated in vitro and in vivo in the animal model. Background Direct Direct skeletal attachment of limb prostheses is associated with high rate of transcutaneous infection and loosening of the fixture in the medullary canal prompting for careful assessment of various means for enhancing the skin-device and bone-device interface. The SBIP system constitutes a technological platform for different modifications being evaluated previously. Objectives The current study assessed the combination of nano treatment SBIP with its pre seeding with dermal fibroblasts. We hypothesized that this combination will enhance cell interaction with SBIP compared to nano treatment and the fibroblast seeding when done separately. Methods TiO2 nanotubes were fabricated on the SBIP, and the fibroblasts taken from rabbit's skin were cultured on the pylons before implantation. Results The in vitro experiments demonstrated higher cellular density in the samples with a nanotubular surface than in the non modified pylons used as control. There were no postoperative complications in any of the animals during the 6 month observation period. Subsequent SEM of the pylon extracted from the rabbit's femur showed the stable contact between the pylon and soft tissues in comparison to control samples where the patchy fibrovascular ingrowth was detected. Conclusions The promising results prompt further investigation of the integrative properties of the nanotextured SBIP system seeded with dermal fibroblasts and its optimization for clinical application.

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Section: Discussionsupporting

confidence: 85%

Application of the skin and bone integrated pylon with titanium oxide nanotubes and seeded with dermal fibroblasts

Shevtsov

Yudintceva

Блинова

et al. 2015

Prosthetics &Amp; Orthotics International

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“… (a) Schematic view of implant with side fins “ 1 ” positioned in precut slot in bone walls “ 2 .” Figure adapted from Pitkin et al [28]. (b) Press-fitting of fin (“ 1 ” in (a) ) to slot in bone wall results in Ilizavov type distraction (red arrows) and compression (blue arrow) due to elastic resistance of bone wall to widening.…”

Section: Figurementioning

confidence: 99%

“…As was shown in a recent review [26], the SBIP is principally distinguished from other systems for DSA because it provides conditions for the ingrowth of skin and bone cells throughout the entire volume of the implant [27–28]. Histological analysis demonstrated that the porosity, volume fraction, and pore size in the SBIP implants were conducive for cells to grow throughout the volume of the implant effectively [29].…”

Section: Introductionmentioning

confidence: 99%

New method of fixation of in-bone implanted prosthesis

Pitkin

Cassidy²,

Muppavarapu³

et al. 2013

JRRD

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This article presents results on the effectiveness of a new version of the titanium porous composite skin and bone integrated pylon (SBIP). The SBIP is designed for direct skeletal attachment of limb prostheses and was evaluated in a pre-clinical study with three rabbits. In accordance with the study protocol, a new version of the pylon (SBIP-3) was implanted into the hind leg residuum of three rabbits. The SBIP-3 has side fins that are designed to improve the bond between the bone and pylon. The fins are positioned inside two slots precut in the bone walls; their length can be adjusted to match the thickness of the bone walls. After 13 (animal 1) or 26 wk (animals 2 and 3), the animals were sacrificed and samples collected for histopathological analysis. The space between the fins and the bone into which they were fit was filled with fibro-vascular tissue and woven bone. No substantial inflammation was found. We suggest that if further studies substantiate the present results, the proposed method can become an alternative to the established technique of implanting prostheses into the medullar canal of the hosting bone.

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“…7), developed for approximation of a composite structure by a homogeneous rod [18]:

S = \frac{L F}{π r^{3}}

where L is the span, F is the bending force, and r is the radius of the pylon.…”

Section: Resultsmentioning

confidence: 99%

“…The new development compared to previous reports [14, 18] is that the insert is manufactured with a spiral pattern of drilled holes running along the webs in order to make the pylons more permeable for better in-growth of bone and skin cells such that the pylon becomes an integral part of the skeleton.…”

Section: Introductionmentioning

confidence: 99%

Mechanical properties of totally permeable titanium composite pylon for direct skeletal attachment

Pitkin¹,

Pilling²,

Raykhtsaum³

2012

J Biomed Mater Res

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Composite pylons containing a solid titanium core with drilled holes surrounded by a porous sintered titanium shell have been fabricated and tested in bending along with the raw cores and pylons composed of the porous titanium alone. The new pylons were designed with the concept of enhanced ingrowth of bone and skin cells and are intended for direct skeletal attachment of limb prostheses considering requirements for long-lasting anchorage to the residuum bone and a need for a safe skin-implant seal. Load-displacement thresholds were determined after which the integrity of the porous component may be compromised. The composite pylons have a flexural strength and stiffness substantially greater than that of pylons composed of the porous titanium alone. The drilled holes in the solid insert have been shown to have virtually no effect on the flexural strength of the pylon, while meeting a requirement for total permeability of the device for unrestricted cell ingrowth. The predicted strength of the pylons and associated failure modes are in close agreement with those measured.

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Porous composite prosthetic pylon for integration with skin and bone

Cited by 23 publications

References 39 publications

Application of the skin and bone integrated pylon with titanium oxide nanotubes and seeded with dermal fibroblasts

Application of the skin and bone integrated pylon with titanium oxide nanotubes and seeded with dermal fibroblasts

New method of fixation of in-bone implanted prosthesis

Mechanical properties of totally permeable titanium composite pylon for direct skeletal attachment

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