Porous nanoparticles with engineered shells release their drug cargo in cancer cells

Qiu, Jingwen; Li, Xue; Rezaei, Mahsa; Patriarche, G.; Casas‐Solvas, Juan M.; Moreira-Alvarez, Borja; Costa‐Fernández, José M.; Encinar, Jorge Ruiz; Savina, Farah; Picton, Luc; Vargas‐Berenguel, Antonio; Gref, Ruxandra

doi:10.1016/j.ijpharm.2021.121230

Cited by 8 publications

(7 citation statements)

References 45 publications

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“…Results of 27 Al and 31 P MAS NMR in Figure S14a and Figure S14b agree with our previous study 24 . 31 P MAS NMR (Figure S16b) showed that the drug ATP is captured inside MIL-100(Al) by chemical adsorption through Al-O-P coordination. 27 Al MAS NMR (Figure S16a) showed that the CD-P coating is located at the surface and does not penetrate the MOF core.…”

Section: Degradation Mechanism Of Nanomil-100(al)mentioning

confidence: 99%

“…(1) Experimental procedures of nanoMOF preparation and characterization, (2) standard characterization of nanoMIL-100(Al): DLS, TEM, XRD, BET, TGA, and 1 H MAS NMR, 13 C MAS NMR, 27 Al MAS, and MQMAS NMR spectra, and (3) complementary NMR measurements on degraded nanoMIL-100(Al): 31 P, 1 H-31 P, and…”

Section: * Sı Supporting Informationmentioning

confidence: 99%

“…ATP and CD-P were chosen based on their well-known interaction between molecules bearing phosphate moieties and the Al(III) cations of nanoMIL-100(Al). 24,26 The ensemble of ssNMR data ( 27 Al, 31 P, and 31 P-27 Al) reveals the evolution of the metal coordination sphere in MIL-100 during the degradation reaction as a function of several parameters: MIL-100 structure, concentration of the degradation medium, interaction with surface coating, and loaded drug. To check whether our proposed degradation mechanism applies to the iron MIL-100 analog, we studied the degradation of nanoMIL-100(Fe) in PBS by XANES spectroscopy, which was selected because it can provide information about the local structure of iron(III) in MOFs.…”

Section: Introductionmentioning

confidence: 99%

“…More recently, DOX was efficiently encapsulated (74% encapsulation efficiency) in core–shell nanoMIL-100(Al) coated with γ-cyclodextrin (CD) citrate and was released progressively depending on the initial drug loading . Both nanoMIL-100(Al) and nanoMIL-100(Fe) demonstrated high loading capacity for active molecules bearing phosphate moieties because of the strong interaction between Al(III) or Fe(III) CUS and phosphate group. ,, Additionally, to improve the nanoMOF’s colloidal stability and to modulate their interaction with biological media and cells, the surface of nanoMIL-100(Fe) and nanoMIL-100(Al) was coated covalently with polymers or non-covalently with biopolymers, lipids, and carbohydrates. ,− More importantly, for biomedical applications, nanoMIL-100(Fe) has been shown non-toxic and biodegradable in vitro ,, and in vivo. ,,, NanoMIL-100(Al) has also been shown non-toxic in vitro.…”

Section: Introductionmentioning

confidence: 99%

“…Both nanoMIL-100(Al) and nanoMIL-100(Fe) demonstrated high loading capacity for active molecules bearing phosphate moieties because of the strong interaction between Al(III) or Fe(III) CUS and phosphate group 14,18,24 . Additionally, to improve the nanoMOF's colloidal stability and to modulate their interaction with biological media and cells, the surface of nanoMIL-100(Fe) and nanoMIL-100(Al) was coated covalently with polymers 25 or non-covalently with biopolymers, lipids and carbohydrates 15,[26][27][28][29][30][31] . More importantly, for biomedical applications, nanoMIL-100(Fe) has been shown non-toxic and biodegradable in vitro 2,32,33 and in vivo 2,21,34,35 .…”

mentioning

confidence: 99%

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Degradation Mechanism of Metal–Organic Framework Drug Nanocarriers Studied by Solid-State Nuclear Magnetic Resonance and X-ray Absorption Near-Edge Structure Spectroscopy

et al. 2022

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Metal-organic framework nanoparticles (nanoMOFs) are novel porous drug delivery systems whose features include high drug loading capacity, versatile functionalization, biocompatibility, and biodegradability. However, little knowledge about the nature of nanoMOFs degradation mechanism is one of many reasons that prevents their clinical use. MIL-100 (MIL stands for Matériaux de l'Institut Lavoisier) is among the most studied nanoMOF for drug delivery.Here, we investigate at the atomic scale the degradation mechanism of metal(III)-trimesate nanoMIL-100 drug carrier in biological-mimicking phosphate medium. By using solid-state NMR (ssNMR) spectroscopy, we found that the first step of nanoMIL-100(Al) degradation is the substitution of labile water ligands, resulting in new coordination bonds between Al(III) and phosphate ions, followed by the substitution of trimesate ligands leading to their release. The data indicated that the reaction-limiting step most likely is the formation of an inorganic aluminophosphate layer at the nanoparticle surface and that drug encapsulation and surface coating affect the nanoMIL-100(Al) degradation. X-ray Absorption Near Edge Structure (XANES) spectroscopy study of nanoMIL-100(Fe) degradation corroborates the hypothesized alteration mechanism of nanoMIL-100(Al). From the ensemble of data, a stepwise degradation mechanism representative for the nanoMIL-100 drug delivery system is proposed.

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