Porphyria Cutanea Tarda Presenting as Erythema-multiforme Like Lesions

Parajuli, Niraj; Jha, Harendra Kumar; Jonkman, Marcel F.

doi:10.33314/jnhrc.v17i01.1132

Cited by 2 publications

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“…In our study, the most common age group for non-malignant (benign and inflammatory) breast lesions was between 30 and 39 years (40.5%), with a secondary peak age group of 20-29 years (16.8%). These findings are consistent with a study conducted in Nepal, where the peak age for benign breast lesions was between 31 and 40 years (40%), with a second peak of 21-30 years (32%) [26]. Similarly, Kapoor et al (2020) [3] observed in their study that the age group of 30-49 years had the highest incidence of benign breast diseases (62.85%).…”

Section: Discussionsupporting

confidence: 89%

Histopathological Profile of Different Breast Lesions: A Single-Center Observational Study

Ibrahim,

Ali,

Sharbatti

et al. 2024

Cureus

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Objective: To describe the histopathological pattern of different breast lesions among tissue specimens sent to our laboratory. Method: A record-based study using a retrospective review of 255 histologically diagnosed breast biopsy reports in the histopathology department of authors from December 2016 to November 2021 was conducted. The specimens were collected from core biopsy, lumpectomy, and mastectomy. All data obtained were analyzed using the Statistical Package for the Social Sciences (SPSS) version 28 (IBM SPSS Statistics, Armonk, NY). Then, the findings were presented using text, tables, and charts. Result: A total of 255 breast lesions were analyzed in this study. Most of the cases were benign (58.8%), followed by inflammatory lesions (21.6%), and malignant (19.6%). Fibroadenoma was the most prevalent benign lesion (36.7%), and most of the patients (70.9%) were in the age group of 20-39 years old. The most common inflammatory lesion was granulomatous mastitis (56.4%), and most of the cases were diagnosed in the age group of 30-39 years old. Invasive ductal carcinoma (IDC) was the most encountered histological type of carcinoma (62%). Of the malignant cases, 52% were diagnosed before the age of 50 years. Among these 50 cases, grade 2 was the most prevalent one (46%). Conclusion: Benign breast lesions are more common than malignant breast lesions, and fibroadenoma is the most common benign subtype. Granulomatous mastitis is the most prevalent inflammatory breast lesion. About two-thirds of malignant cases are non-Arab. Invasive ductal carcinoma with no special type (NST) is the most common malignant subtype.

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Section: Discussionsupporting

confidence: 89%

Histopathological Profile of Different Breast Lesions: A Single-Center Observational Study

Ibrahim,

Ali,

Sharbatti

et al. 2024

Cureus

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“…Repeated phototoxic episodes might result in an altered skin appearance with permanent cutaneous manifestations. Moreover, 20-30% of patients have a liver implication, and 5% need liver transplantation [8,[19][20][21][22][23][24][25].…”

Section: Introductionmentioning

confidence: 99%

Psychological Aspect and Quality of Life in Porphyrias: A Review

Granata

Nicolli

Colaiocco³

et al. 2022

Diagnostics

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The World Health Organization (WHO) describes “health” as a state of physical, mental, and social well-being and not merely the absence of disease or infirmity. Therefore, a biopsychosocial approach should be considered as an integral part of patients’ management. In this review, we summarize the available data starting from 1986 on the biological, psychological, and social aspects of porphyrias in order to provide a useful tool for clinicians about the missing knowledge within this field. Porphyrias are a group of rare metabolic disorders affecting the heme biosynthetic pathway and can be categorized into hepatic and erythropoietic. Here, a total of 20 articles reporting the psychological and the quality of life (QoL) data of porphyria patients affected by acute hepatic porphyrias (AHPs), Porphyria Cutanea Tarda (PCT), and Erythropoietic Protoporphyria (EPP) were analyzed. These 13 articles include reported quantitative methods using questionnaires, while the reaming articles employed qualitative descriptive approaches through direct interviews with patients by psychology professionals. We conclude that the use of questionnaires limits the complete description of all areas of a patient’s life compared to a direct interview with specialists. However, only a combined use of these methods could be the best approach for the correct disorder management.

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Porphyria Cutanea Tarda Presenting as Erythema-multiforme Like Lesions

Cited by 2 publications

References 0 publications

Histopathological Profile of Different Breast Lesions: A Single-Center Observational Study

Histopathological Profile of Different Breast Lesions: A Single-Center Observational Study

Psychological Aspect and Quality of Life in Porphyrias: A Review

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