Port site metastatic disease in ovarian carcinoma

Sullivan, Robert O’; Shireen, Rizmee; Swafani, Mohd; Curtain, Andrew

doi:10.1007/s11845-015-1257-x

Cited by 6 publications

(1 citation statement)

References 9 publications

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“…Besides the contamination from port catheters and tissue manipulation, pneumoperitoneum, hypercapnia and CO 2 acidemia have been shown to participate in the metastases, while no preventive measure (e.g., oxaliplatin) has been found successful enough. Similarly, the use of paracentesis ascites catheters, and fine-needle biopsy have caused the same complications [24,25,26].…”

Section: Pathways and Metastatic Sites Of Ovarian And Peritoneal Cmentioning

confidence: 99%

Rare Distant Metastatic Disease of Ovarian and Peritoneal Carcinomatosis: A Review of the Literature

Thomakos

Diakosavvas

Machairiotis

et al. 2019

Cancers

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Background: Although metastases of ovarian and peritoneal carcinomatosis are most commonly found within the peritoneal cavity, there is a number of other rare distant sites that have been reported. Our goal is to provide an evidence-based summary of the available literature considering the rare distant metastatic sites of ovarian and peritoneal carcinomatosis. Methods: A comprehensive search of the literature was conducted, with Medline/PubMed being searched for cases of rare metastatic disease originated from primary ovarian and peritoneal cancer with related articles up to 2019 including terms such as “ovarian cancer”, “metastases”, “peritoneal” and others. Results: The most common mechanism of ovarian cancer metastases consists of primarily dissemination within the peritoneal cavity, while, rare and distant sites can either occur at the beginning or during the course of the disease and they are usually associated with hematogenous route and lymphatic invasion, having poor prognosis, with the least common sites being skin, bone, CNS, eye, placenta, central airways, rare lymph nodes, intra-abdominal organs, heart and breast. Conclusions: The occurrence of metastatic sites described in this review represents the most common rare distant metastatic sites, and even though their patterns of metastases are still not fully clarified due to the rarity of the reports, they offer valuable information considering the pathophysiology of the disease.

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Section: Pathways and Metastatic Sites Of Ovarian And Peritoneal Cmentioning

confidence: 99%

Rare Distant Metastatic Disease of Ovarian and Peritoneal Carcinomatosis: A Review of the Literature

Thomakos

Diakosavvas

Machairiotis

et al. 2019

Cancers

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Port site metastases after minimally invasive resection for colorectal cancer: A retrospective study of 13 patients

et al. 2019

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An unusual case of sarcomatoid renal cell carcinoma presenting in the skin by direct extension at a laparoscopic port site

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Gru

2020

J Cutan Pathol

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Although renal cell carcinoma (RCC) is known for its propensity to metastasize widely throughout the body, cutaneous metastases are uncommon and seen in less than 3% of RCCs. A 56‐year‐old man presented with a painful red lesion with satellite nodules on his abdomen at a laparoscopic port site from a partial nephrectomy for a pT1a clear‐cell RCC that was performed 28 months prior. The lesion was excised; however, after excision the lesion recurred with continued pain and drainage from the surgical site. This was treated with multiple courses of antibiotics. Because of the persistent nature of the lesion, it was re‐biopsied, and an atypical, keratin‐positive, spindle‐cell proliferation was identified within the dermis. The patient's previous skin excision was reexamined, and the same atypical cells were identified within large areas of necrosis, granulation tissue, and fibrosis. Further workup was performed on the initial excision, and the atypical cells showed expression of CD10, CAIX, PAX8, EMA, and vimentin, consistent with cutaneous involvement by RCC. Because of the rarity of skin metastases in RCC and the location at a previous laparoscopic port site, this lesion is presumed to have resulted from direct extension of tumor at the time of surgery.

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Port site metastatic disease in ovarian carcinoma

Abstract: In all cases, port-site metastatic disease developed rapidly and was clinically suspected at the time of definitive surgery. We recommend that consideration be given towards removing port sites when performing cytoreductive surgery for gynaecological malignancy.

Cited by 6 publications

References 9 publications

Rare Distant Metastatic Disease of Ovarian and Peritoneal Carcinomatosis: A Review of the Literature

Rare Distant Metastatic Disease of Ovarian and Peritoneal Carcinomatosis: A Review of the Literature

Port site metastases after minimally invasive resection for colorectal cancer: A retrospective study of 13 patients

An unusual case of sarcomatoid renal cell carcinoma presenting in the skin by direct extension at a laparoscopic port site

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