Portable GMR Handheld Platform for the Detection of Influenza A Virus

Wu, Kai; Klein, Todd; Krishna, Venkatramana D.; Su, Diqing; Pérez, Andrés; Wang, Jian Ping

doi:10.1021/acssensors.7b00432

Cited by 110 publications

(95 citation statements)

References 36 publications

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“…[114][115][116] Through surface modification of MNPs, this platform can be widely used for detection of several biological targets as shown in Figure 5A,B. [113,[117][118][119][120][121][122].…”

Section: Gmr-based Bioassaymentioning

confidence: 99%

Magnetic Particles: Their Applications from Sample Preparations to Biosensing Platforms

et al. 2020

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The growing interest in magnetic materials as a universal tool has been shown by an increasing number of scientific publications regarding magnetic materials and its various applications. Substantial progress has been recently made on the synthesis of magnetic iron oxide particles in terms of size, chemical composition, and surface chemistry. In addition, surface layers of polymers, silica, biomolecules, etc., on magnetic particles, can be modified to obtain affinity to target molecules. The developed magnetic iron oxide particles have been significantly utilized for diagnostic applications, such as sample preparations and biosensing platforms, leading to the selectivity and sensitivity against target molecules and the ease of use in the sensing systems. For the process of sample preparations, the magnetic particles do assist in target isolation from biological environments, having non-specific molecules and undesired molecules. Moreover, the magnetic particles can be easily applied for various methods of biosensing devices, such as optical, electrochemical, and magnetic phenomena-based methods, and also any methods combined with microfluidic systems. Here we review the utilization of magnetic materials in the isolation/preconcentration of various molecules and cells, and their use in various techniques for diagnostic biosensors that may greatly contribute to future innovation in point-of-care and high-throughput automation systems.

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Section: Gmr-based Bioassaymentioning

confidence: 99%

Magnetic Particles: Their Applications from Sample Preparations to Biosensing Platforms

et al. 2020

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“…In addition, the passivation layers must be of low energy states such that it encourages surface immobilization of the biological molecules. The most commonly used passivation layers for MR sensors are SiO 2 , Al 2 O 3 , and Si 3 N 4 , with a thickness of 50 nm to 200 nm [21,[62][63][64]. One example of surface functionalization based on the passivation layers is as follows: ultraviolet oxygen plasma (UVO) treatment will firstly be employed to remove any contaminants on the surface of the sensor.…”

Section: Design Of Passivation Layermentioning

confidence: 99%

“…Later on, the GMR-based biosensing system has been tested for the detection of various biomarkers such as prostate cancer [105], ovarian cancer [18], lung cancer [17], etc. The detection of other types of analytes, such as viruses [21,64,86], bacterias [106,107], and toxic ions [93] have also been demonstrated. Besides single-analyte detection, the possibility of multiplexed immunoassay was also explored.…”

Section: Gmr-based Biosensorsmentioning

confidence: 99%

Advances in Magnetoresistive Biosensors

Saha

et al. 2019

Micromachines

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Magnetoresistance (MR) based biosensors are considered promising candidates for the detection of magnetic nanoparticles (MNPs) as biomarkers and the biomagnetic fields. MR biosensors have been widely used in the detection of proteins, DNAs, as well as the mapping of cardiovascular and brain signals. In this review, we firstly introduce three different MR devices from the fundamental perspectives, followed by the fabrication and surface modification of the MR sensors. The sensitivity of the MR sensors can be improved by optimizing the sensing geometry, engineering the magnetic bioassays on the sensor surface, and integrating the sensors with magnetic flux concentrators and microfluidic channels. Different kinds of MR-based bioassays are also introduced. Subsequently, the research on MR biosensors for the detection of protein biomarkers and genotyping is reviewed. As a more recent application, brain mapping based on MR sensors is summarized in a separate section with the discussion of both the potential benefits and challenges in this new field. Finally, the integration of MR biosensors with flexible substrates is reviewed, with the emphasis on the fabrication techniques to obtain highly shapeable devices while maintaining comparable performance to their rigid counterparts.

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“…A very broad concept is introduced here. Biological objects such as bacteria, 123 viruses, 124 and parasites 125 are in the micrometer to submicrometer range; therefore, magnification is mandatory for visual inspection of these objects. Smartphone adapters are employed here for visual inspection, measurement, recognition, 126 sensing, 127 and disease diagnosis [128][129][130] for conditions such as diabetes, cancer, 131 and malaria.…”

Section: Biochemical Applicationsmentioning

confidence: 99%

A review of smartphone point‐of‐care adapter design

Alawsi

Al-Bawi

2019

Engineering Reports

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In this review, we explore the potential of smartphone‐based applications based on their unique ability to support portable, easy‐to‐use, precise, and efficient functions, which, in turn, makes lab‐on‐hardware a trending area of novel research. Smartphones can assist surgeons, physicians, biologists, chemists, ophthalmologists, and laboratory technicians in maintaining an easy‐to‐use, cost‐effective, and integrated environment for treatment, diagnosis, and point‐of‐care (POC) applications. These POC applications can improve patients' quality of life, offering patients a precise diagnosis and the correct treatment. This is a noble goal that aims to reduce costs and to increase the accuracy of sample testing, treatment, and diagnosis. Recent innovations have made major advances in smartphone adapters, providing portability, robustness, self‐powered devices, small‐sized adapters, and ease of usage. Lab‐on‐hardware is a progressing field, and smartphone imaging applications are increasingly expanding, resulting in POC applications with the latest and most advanced image analysis, enhancement, recognition, and other image processing techniques. The most recent studies in the field are explored to provide a solid background to interested researchers against which they can choose of application and/or adapter design they aim to develop, with a discussion of the methods reviewed here.

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Portable GMR Handheld Platform for the Detection of Influenza A Virus

Cited by 110 publications

References 36 publications

Magnetic Particles: Their Applications from Sample Preparations to Biosensing Platforms

Magnetic Particles: Their Applications from Sample Preparations to Biosensing Platforms

Advances in Magnetoresistive Biosensors

A review of smartphone point‐of‐care adapter design

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