Portable ultraviolet light A1 light source to treat hypertrophic scar

Abstract

a b s t r a c tBackground/Objectives: Recently, fibrotic diseases such as hypertrophic scar, keloid, and scleroderma have been treated with UV-A1 radiation with encouraging results. However, conventional UV light sources are bulky and expensive. In this study, we aimed to verify the effectiveness of a portable UV-A1 radiation device in treating hypertrophic scars. Materials and methods: A light-emitting diode array that emitted 365 ± 5 nm (UV-A1) was used to irradiate fibroblasts and hypertrophic scar in a rabbit model. Results: In cell cultures, UV-A1 light exposure inhibited post-wound cell migration and reduced the total amount of soluble collagen production in fibroblasts. Type I collagenase production and its activity increased after treatment. On the rabbit ear, UV-A1 light irradiation reduced the thickness of hypertrophic scars, confirming the antifibrotic effect in vivo. Conclusion: These results support the potential of a portable UV-A1 light device in treating hypertrophic scar.

Cryosurgery to remove perichondrium for the rabbit ear hypertrophic scar model: a simplified method

“…The rabbit ear hypertrophic scar model (REHSM) is one of the most advanced animal models of excessive scarring because it provides reproducible scars similar to human scarring with regard to their macroscopic and histological appearance (1,2). These scars persist for months and respond to scar-modulating treatments with various agents (1)(2)(3)(4). The model is based on the removal of skin and underlying perichondrium at least 7 mm in diameter using a punch biopsy with a corresponding size ( Fig.…”