Portal vein embolization before major hepatectomy and its effects on regeneration, resectability and outcome (<i>Br J Surg</i> 2007; 94: 1386–1394)

Werkgartner, Georg

doi:10.1002/bjs.6166

Cited by 5 publications

(1 citation statement)

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“…The finding show that this preparation has significantly depressant effect and preonunced curative effect on a variety of cancer cells [ 9 ]. Although the therapeutic measure of liver cancer contain surgery, radiotherapy, chemotherapy, interventional therapy and so on, their effect is not satisfactory so far [ 10 , 11 ]. However, with the development of cell biology, the theory of apoptosis presents a new hope and path for the treatment of liver cancer, The present study has found that KLT plays an important role in promoting apoptosis of hepatoma cells [ 12 ].…”

Section: Reviewmentioning

confidence: 99%

Chinese herb related molecules of cancer-cell-apoptosis: a minireview of progress between Kanglaite injection and related genes

Dong

2008

J Exp Clin Cancer Res

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Many kinds of Chinese herb had been confirmed to have the character of anti-tumor, clinical reports about anti-tumor effects of Chinese herb had also been found in recent years, but most of the reports were focused on the clinical treatment of effectiveness for Chinese herb, on the other hand, review about Chinese herbal related with molecules on cancer-cell-apoptosis was seldom, many scientists could not believe such kinds of clinical describes about anti-tumor effects for Chinese herb, because these describes were lack of molecular biology evidence. Kanglaite(KLT) injection is an anti-tumor new drug which extracts from Chinese medicine-coix seed with modern advanced pharmaceutical technology, it is also a new biphase extended-spectrum anticancer medicine, the food and drug administration(FDA) of United States also approved a phase II trial of KLT to test its efficacy in treating non-small-cell lung cancer. Some studies show it could inhibit some anti-apoptotic gene and activate some pro-apoptotic gene, its injection solution is one of the new anticancer medicine that can significantly inhibit a various kinds of tumor cells, so it has become the core of research that how to further explore KLT injection to promote tumor cell apoptosis by impacting on related genes. In this review, the relationship between KLT and some tumor cell apoptosis molecules had been discussed and reviewed generally. ReviewIn recent years, with the lucubrate on tumor cell biology and molecular biology, it has been recognized that the occurrence and development of tumor is not only the result of cell proliferation disorders and disdifferentiation, but also closely correlated with the abnormal apoptosis [1,2]. Although abnormal apoptosis can promote the occurrence and development of tumor, we can also treat tumor by promoting apoptosis of cancer cell [3,4]. Thus it has become the new target in oncotherapy by way of inducing apoptosis of cancer cell. Kanglaite(KLT) injectionis a diphasic broad-spectrum anti-tumor new drug which has depressant effect on many kinds of tumor cells, it is extracted from the chinese crude drug-coixenolide [5,6] and made use of the latest and most complex modern high technologies in process of preparation [7]. Animal experiments show that KLT mainly block G2+M phase of cell circle, thereby reducing the mitotic division

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Section: Reviewmentioning

confidence: 99%