Pos-136 Acute Post-Infectious Glomerulonephritis in Adults: Epidemiological Profile

Abstract

Introduction: Acute post-infectious glomerulonephritis is caused by a non-suppurative inflammatory reaction resulting from an immune response to an infection. we will study the epidemiological, clinical and paraclinical characteristics of acute post-infectious glomerulonephritis in adults Methods: We have conducted a retrospective study; including 54 patients diagnosed with acute post-infectious glomerulonephritis. Results: The median age was 37.5 years, the sex ratio was 4.4 (H/F). The percentage of patients with a history of diabetes was 7.4%, hypertension 7.4%, history of recurrent angina 10%. The initial clinical presentations were variable: the oedematous syndrome was presented by 48.1% of patients, 22.2% for acute nephritic syndrome, 11.1% for advanced renal failure, 7.4% for impure nephrotic syndrome, 5.6% for renal failure. The percentage of patients who presented an infectious episode preceding the initial symptomatology with a variable free interval is 72.2%. The most frequent site of infection was upper respiratory tract (37%), the percentage of lower lung infections was 11.1%, 9.3% for skin infections, 7.4% for urinary tract infections, and 33.3% of patients had no infectious site.The median systolic and diastolic blood pressure was 152 mmHg and 88.7 mmHg respectively. For the evolution of arterial hypertension: 55.6% of patients have a balanced blood pressure under treatment and 38.9% without treatment; in 5.6% of patients the control was not done.The median creatinine and proteinuria of 24 hour on admission was 150 mmol and 2.6 g/24h respectively. The percentage of patients who presented a persistence of urinary sediment abnormalities during surveillance was 62.5% for hematuria and proteinuria at the urinary strip. It was noted that 25.9% of patients presented a persistence of proteinuria of 24 hours. All patients have benefited renal puncture biopsy which showed endocapillary and extracapillary proliferation in 9 patients (22.5%).End-stage renalfailure was noted in 7.5% of patients, 2.5% for stage 3 CKD, 7.5% for stage 2 CKD and 60% for stage 1 CKD. Conclusions: The clinical and evolution symptoms of acute post-infectious glomerulonephritis in adults were variable and different from those in children.No conflict of interest