Position statement of the Brazilian Academy of Rhinology on the use of antihistamines, antileukotrienes, and oral corticosteroids in the treatment of inflammatory sinonasal diseases

Mion, Olavo; Mello, João Ferreira de; Dutra, Daniel Lorena; Andrade, Nilvano Alves de; Almeida, Washington; Anselmo-Lima, Wilma Teresinha; Filho, Leonardo Lopes Balsalobre; Castro, Jair de Carvalho e; Guimarães, Roberto Eustáquio dos Santos; Lessa, Marcus Miranda; Maniglia, Sergio; Meireles, Roberto Campos; Nakanishi, Márcio; Pignatari, Shirley Shizue Nagata; Roithmann, Renato; Romano, Fabrizio Ricci; Santos, Rodrigo de Paula; Santos, Marco César Jorge dos; Tamashiro, Edwin

doi:10.1016/j.bjorl.2017.01.002

Cited by 5 publications

(2 citation statements)

References 77 publications

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“…Together with LTRA, studies have shown benefits in improving sleep quality and in reducing nasal congestion and complications. 14,15 The efficacy of antihistamines is most often restricted by the sedation associated with it and is caused primarily by its inhibition of the central histamine neurons in the brain. 16 Bilastine was reported as the least sedative antihistamine by majority (41.55%) of the physician.…”

Section: Discussionmentioning

confidence: 99%

Physicians perception in the management of allergic rhinitis: a Pan-India survey

Bhagat

Patil

Panchal

et al. 2020

Int J Otorhinolaryngol Head Neck Surg

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Background: Allergic rhinitis (AR) affects a wide proportion of the population across all age groups. There are several guidelines and consensus statements in AR management, the effect of this is implicit from a physician's perspective. The present cross-sectional survey was conducted to understand physicians approach to the management algorithm in the treatment of allergic rhinitis and medication choice.Methods: Physicians from diverse specialties such as pulmonologists, consultant physician, paediatricians, Allergists, ENT specialists and general practitioners were invited to participate in the survey, which focused on recognizing the burden of disease, clinical presentation, and management methods.Results: 1,261 Physicians participated in this survey, belonging to different specialties. Oral H1 antihistamine was favoured as a first-line therapy, followed by the combination of oral H1 histamine and leukotriene receptor antagonist. Fexofenadine was the most frequently prescribed. Majority believed, bilastine as antihistamine with the least sedative potential and was identified as the most effective treatment. Bilastine was preferred in patients with mild- moderate hepatic/renal impairment and in patients with persistent allergic rhinitis. Most physicians prefer bilastine in all AR clinical profiles. Aside from AR, bilastine is also use in management of upper respiratory tract infections and urticaria respectively.Conclusions: AR is still a growing challenge in India with majority of physician preferring oral antihistamine either as monotherapy or in combination. Bilastine is a preferred choice in patients with impaired liver and renal function and was also referred as least sedative antihistamine by majority of physicians across India.

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Section: Discussionmentioning

confidence: 99%

Physicians perception in the management of allergic rhinitis: a Pan-India survey

Bhagat

Patil

Panchal

et al. 2020

Int J Otorhinolaryngol Head Neck Surg

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“…Однако результаты многочисленных исследова-ний в этой области показали их эффективность только при сопутствующем аллергическом рините [70].…”

Section: антигистаминная терапияunclassified

Place of Topical Steroid Therapy in the Treatment of Acute Rhinosinusitis

Косяков¹,

Минавнина²

2017

Medicinskij sovet

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С.Я. КОСЯКОВ, д.м.н., профессор, Ю.В. МИНАВНИНА Российская медицинская академия непрерывного профессионального образования, Москва МЕСТО ТОПИЧЕСКОЙ СТЕРОИДНОЙ ТЕРАПИИ В ЛЕЧЕНИИ ОСТРОГО РИНОСИНУСИТАОстрый риносинусит -это распространенное воспаление носа и околоносовых пазух. Диагноз «синусит» основывается на сочетании клинических данных с осмотром, данными инструментальных исследований. На вирусные ОРС приходится свыше 90% случаев заболевания. Бактериальная этиология синусита имеет место примерно в 55-65% случаев. Целью лечения острого РС является ликвидация очага инфекции, восстановление пассажа в области остиомеатального комплекса, налаживание дренажной функции, уменьшение воспаления и облегчение симптомов, таких как боль и заложенность носа. Основными направлениями лечения являются антибактериальная терапия, ирригация, противовоспалительная терапия. Топические кортикостероиды -препараты первой линии, наряду с ирригацией. Они могут использоваться как в качестве монотерапии, так и в дополнение к антибактериальной терапии. При легких формах ОРС мометазон в дозе 400 мкг/сут оказался значительно более эффективным, чем плацебо и амоксициллин. А добавление топических кортикостероидов (МФ) к стандартному курсу системной антибиотикотерапии (амоксициллин/клавуланат, цефуроксим) значительно быстрее по сравнению с плацебо облегчало симптомы острого РС и ускоряло выздоровление. Интраназальные стероиды помогают в лечении дневного кашля. При сравнении с лечением другими ИГКС мометазон обладает большей эффективностью, безо-пасностью, лучшим разрешением симптомов, меньшей стоимостью лечения. Мометазон может использоваться беременны-ми женщинами без опасения системных проявлений. Ключевые слова: острый риносинусит, топические стероиды, мометазона фуроат. S.Ia. KOSYAKOV, PhD in medicine, professor, J.V. MINAVNINA, FSBEI FPE Russian Medical Academy of Continuous Professional Education, Moscow PLACE OF TOPICAL STEROID THERAPY IN THE TREATMENT OF ACUTE RHINOSINUSITISAcute rhinosinusitis is a common inflammation of the nose and paranasal sinuses. The sinusitis diagnosis is based on a combination of clinical data with examination, data of instrumental studies. Viral ARS accounts for more than 90 per cent of cases. The bacterial etiology of sinusitis occurs in around 55-65% of cases. The purpose of the treatment of the acute RS is to eliminate the focus of infection, restore the ostiomeatal complex, regulate a drainage function, reduce inflammation and alleviate symptoms such as pain and nasal congestion. The main areas of treatment are antibacterial therapy, irrigation, anti-inflammatory therapy. Topical corticosteroids -first line drugs, along with irrigation. They can be used both as monotherapy as well as in addition to antibacterial therapy. In the light forms of ARS mometazone at a dosage of 400 μg per day was much more efficient than placebo and amoxicillin. And the addition of topical corticosteroids (MF) to the standard course of system antibiotic therapy (amoxicillin/clavulanate, cefuroxime) was much faster than the placebo...

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Leukotriene Receptor Antagonists

Zheng

Tian

Yang

2022

Chronic Rhinosinusitis

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Position statement of the Brazilian Academy of Rhinology on the use of antihistamines, antileukotrienes, and oral corticosteroids in the treatment of inflammatory sinonasal diseases

Abstract: There is support in the literature for the use of these drugs; however, final considerations about the role of each of them have been made.

Cited by 5 publications

References 77 publications

Physicians perception in the management of allergic rhinitis: a Pan-India survey

Physicians perception in the management of allergic rhinitis: a Pan-India survey

Place of Topical Steroid Therapy in the Treatment of Acute Rhinosinusitis

Leukotriene Receptor Antagonists

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