Positive correlation between latent Epstein-Barr virus infection and severity of illness in inflammatory bowel disease patients

Wei, Hongtao; Xue, Xiang; Ling, Qing; Wang, Pengyan; Zhou, Weixun

doi:10.4240/wjgs.v15.i3.420

Cited by 4 publications

(2 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The results of KEGG-enriched pathways is very interesting. EBV infection disrupts cellular immunity, and its presence increases IBD and RA incidences ( 65 , 66 ). JAK–STAT signaling is an essential pathway in immunology, which is generally activated, phosphorylated, and dimerized by the phosphorylation of intracellular JAK, which further activates STAT.…”

Section: Discussionmentioning

confidence: 99%

Inflammatory bowel disease and rheumatoid arthritis share a common genetic structure

Cao,

Luo,

et al. 2024

Front. Immunol.

View full text Add to dashboard Cite

BackgroundThe comorbidity rate of inflammatory bowel disease (IBD) and rheumatoid arthritis (RA) is high; nevertheless, the reasons behind this high rate remain unclear. Their similar genetic makeup probably contributes to this comorbidity.MethodsBased on data obtained from the genome-wide association study of IBD and RA, we first assessed an overall genetic association by performing the linkage disequilibrium score regression (LDSC) analysis. Further, a local correlation analysis was performed by estimating the heritability in summary statistics. Next, the causality between the two diseases was analyzed by two-sample Mendelian randomization (MR). A genetic overlap was analyzed by the conditional/conjoint false discovery rate (cond/conjFDR) method.LDSC with specific expression of gene analysis was performed to identify related tissues between the two diseases. Finally, GWAS multi-trait analysis (MTAG) was also carried out.ResultsIBD and RA are correlated at the genomic level, both overall and locally. The MR results suggested that IBD induced RA. We identified 20 shared loci between IBD and RA on the basis of a conjFDR of <0.01. Additionally, we identified two tissues, namely spleen and small intestine terminal ileum, which were commonly associated with both IBD and RA.ConclusionHerein, we proved the presence of a polygenic overlap between the genetic makeup of IBD and RA and provided new insights into the genetic architecture and mechanisms underlying the high comorbidity between these two diseases.

show abstract

Section: Discussionmentioning

confidence: 99%

Inflammatory bowel disease and rheumatoid arthritis share a common genetic structure

Cao,

Luo,

et al. 2024

Front. Immunol.

View full text Add to dashboard Cite

show abstract

“…In this disease, the immune system’s irregular response to the intestinal mucosa leads to chronic inflammation, which ultimately leads to tissue damage [ 140 ]. Recent studies emphasize the role of microorganisms in the pathogenesis and progression of IBD [ 141 ]. Significant changes in the population composition of the intestinal virome can play an effective role in the initiation and development of IBD, which is associated with chronic and systemic immune disorders [ 142 ].…”

Section: Immune System Diseasesmentioning

confidence: 99%

The mysterious anelloviruses: investigating its role in human diseases

Sabbaghian,

Gheitasi,

Shekarchi

et al. 2024

BMC Microbiol

View full text Add to dashboard Cite

Anelloviruses (AVs) that infect the human population are members of the Anelloviridae family. They are widely distributed in human populations worldwide. Torque teno virus (TTV) was the first virus of this family to be identified and is estimated to be found in the serum of 80–90% of the human population. Sometime after the identification of TTV, Torque teno mini virus (TTMV) and Torque teno midi virus (TTMDV) were also identified and classified in this family. Since identifying these viruses, have been detected in various types of biological fluids of the human body, including blood and urine, as well as vital organs such as the liver and kidney. They can be transmitted from person to person through blood transfusions, fecal-oral contact, and possibly sexual intercourse. Recent studies on these newly introduced viruses show that although they are not directly related to human disease, they may be indirectly involved in initiating or exacerbating some human population-related diseases and viral infections. Among these diseases, we can mention various types of cancers, immune system diseases, viral infections, hepatitis, and AIDS. Also, they likely use the microRNAs (miRNAs) they encode to fulfill this cooperative role. Also, in recent years, the role of proliferation and their viral load, especially TTV, has been highlighted to indicate the immune system status of immunocompromised people or people who undergo organ transplants. Here, we review the possible role of these viruses in diseases that target humans and highlight them as important viruses that require further study. This review can provide new insights to researchers.

show abstract

Enhancing Epstein–Barr virus detection in IBD patients with XAI and clinical data integration

Wang,

Chen,

et al. 2025

Computers in Biology and Medicine

View full text Add to dashboard Cite

Positive correlation between latent Epstein-Barr virus infection and severity of illness in inflammatory bowel disease patients

Cited by 4 publications

References 22 publications

Inflammatory bowel disease and rheumatoid arthritis share a common genetic structure

Inflammatory bowel disease and rheumatoid arthritis share a common genetic structure

The mysterious anelloviruses: investigating its role in human diseases

Enhancing Epstein–Barr virus detection in IBD patients with XAI and clinical data integration

Contact Info

Product

Resources

About