Positive correlation between postoperative tumor recurrence and changes in circulating tumor cell counts in pulmonary venous blood (pvCTC) during surgical manipulation in non-small cell lung cancer

Hashimoto, Masaki; Tanaka, Fumihiro; Yoneda, Kazue; Takuwa, Teruhisa; Matsumoto, Seiji; Okumura, Yoshitomo; Kondo, Nobuyuki; Tsujimura, Tohru; Nakano, Takashi; Hasegawa, Seiki

doi:10.21037/jtd.2017.12.56

Cited by 31 publications

(27 citation statements)

References 31 publications

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“…The link between CTC detection in lung cancer and the surgery technique was assessed by few authors. Particularly, it was shown that surgical manipulation significantly increased CTC number in the pulmonary vein and that this was associated with lymphatic invasion and a significant reduction of PFS and OS (Hashimoto et al ., , ). A recent work suggested that intraoperative manipulation contributes to the hematogenous dissemination of tumorigenic CTCs and circulating tumor micro‐emboli (Table ) (Lv et al ., ).…”

Section: Non‐small‐cell Lung Cancermentioning

confidence: 99%

Tumor‐proximal liquid biopsy to improve diagnostic and prognostic performances of circulating tumor cells

et al. 2019

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Circulating tumor cell ( CTC ) detection and numeration are becoming part of the common clinical practice, especially for breast, colon, and prostate cancer. However, their paucity in peripheral blood samples is an obstacle for their identification. Several groups have tried to improve CTC recovery rate by developing highly sensitive cellular and molecular detection methods. However, CTC s are still difficult to detect in peripheral blood. Therefore, their recovery rate could be increased by obtaining blood samples from vessels close to the drainage territories of the invaded organ, when the anatomical situation is favorable. This approach has been tested mostly during tumor resection surgery, when the vessels nearest to the tumor are easily accessible. Moreover, radiological (including echo‐guided based and endovascular techniques) and/or endoscopic routes could be utilized to obtain CTC samples close to the tumor in a less invasive way than conventional biopsies. The purpose of this article is to summarize the available knowledge on CTC recovery from blood samples collected close to the tumor (i.e., in vessels located in the drainage area of the primary tumor or metastases). The relevance of such an approach for diagnostic and prognostic evaluations will be discussed, particularly for pancreatic ductal adenocarcinoma, colorectal adenocarcinoma, hepatocellular carcinoma, and non‐small‐cell lung cancer.

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Section: Non‐small‐cell Lung Cancermentioning

confidence: 99%

Tumor‐proximal liquid biopsy to improve diagnostic and prognostic performances of circulating tumor cells

et al. 2019

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“…Hashimoto et al reported that patients with an increased number of CTCs after surgery are more susceptible to distant metastasis. 14 Some research suggests that CTC count in the PV is related to clinical and histological factors. Reddy et al reported that the number of CTCs in the PV was associated with pathological tumor size.…”

Section: Discussionmentioning

confidence: 98%

“…Hashimoto et al . reported that patients with an increased number of CTCs after surgery are more susceptible to distant metastasis …”

Section: Discussionmentioning

confidence: 99%

Circulating tumor cells in the pulmonary vein increase significantly after lobectomy: A prospective observational study

et al. 2018

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BackgroundIt has been reported that there are more circulating tumor cells (CTCs) in the pulmonary vein (PV) than in the peripheral blood; however, it is unclear whether the CTC count changes in the PV after resection of a lung lobe.MethodsThirty‐three lung cancer patients were recruited for the study, including 17 who underwent lobectomy via video‐assisted thoracoscopic surgery and 16 via open thoracotomy. Sixty‐six blood specimens were sampled from the PV before the PV was interrupted and after lobectomy. The CTCs were quantified using the oHSV1‐hTERT‐GFP method.ResultsBefore PV interruption, the CTC (pre‐CTC) detection rate was 79.0% (26/33), the mean number of CTCs was 3.36 (median 2, range: 0–18), and there was no significant relationship between the pre‐CTC count and clinical factors, such as histologic findings and pathological T stage (P > 0.05). After lobectomy, the CTC (post‐CTC) detection rate was 100% (33/33), the average number of CTCs was 14.88 (median 11, range: 1–69), and the post‐CTC count was significantly higher in patients in whom the PV was interrupted prior to the pulmonary artery (PA) than in patients in whom the PA was interrupted before the PV (P = 0.016). Overall, the CTC count was significantly higher following surgery (P < 0.001).ConclusionPost‐CTC counts were significantly higher than pre‐CTC counts, suggesting that surgical manipulation may potentially dislodge tumor cells into the PV. Interrupting the PV prior to the PA during lobectomy may prevent partial CTC entry into the circulation.

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“…Furthermore, they demonstrated that the PA-first procedure was an independent risk factor for the increase of CTCs during surgery in multivariate analysis. Hashimoto et al (24) reported that increasing CTCs in the PV during surgical manipulation was significantly correlated with postoperative distant metastasis in completely resected NSCLC patients, although neither recurrence-free survival nor overall survival was significantly correlated with the increase in CTCs in PV. Furthermore, Song et al (25) conducted a prospective randomized study related to the invasiveness and adhesiveness of malignant tumor cells and suggested that ligation of the PV should be performed first during lobectomy.…”

Section: Discussionmentioning

confidence: 99%

Wedge Resection of Tumor Before Lobectomy for Lung Cancer Could Be a No-touch Isolation Technique

Yasukawa

Sawabata

Kawaguchi

et al. 2020

In Vivo

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Background/Aim: Circulating tumor cells (CTCs) can be a surrogate biomarker of prospective prognosis. Surgical manipulation can promote the dissemination of CTCs. Prognosis improvement is expected with the no-touch isolation technique (NTIT), preventing surgical manipulation. The Wedge resection of the tumor site before lobectomy could prevent surgical manipulation during lobectomy for nonsmall cell lung cancer (NSCLC) and reduce the shedding of tumor cells, similar to a NTIT. This study aimed to evaluate the effect of wedge resection technique. Patients and Methods: A total of 624 resected NSCLC patients were retrospectively analyzed. Patients were divided in two groups: Wedge and Non-Wedge. Overall survival (OS) curves were plotted using the Kaplan-Meier method. Results: The 5-year OS rates were 89.9% and 84.0% in the Wedge and Non-Wedge groups, respectively (p=0.033). Conclusion: The OS in the Wedge group was significantly better than that in the Non-Wedge group. Wedge resection technique for NSCLC may be a NTIT.779 resection compared to non-wedge resection before lobectomy for NSCLC patients. The aim of this study was to evaluate the effect of wedge resection of the tumor site before lobectomy as a no-touch isolation technique. This is the first study to investigate the efficacy of wedge resection during lobectomy for NSCLC. Yasukawa et al: Effect of Wedge Resection of Tumor for NSCLC

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Positive correlation between postoperative tumor recurrence and changes in circulating tumor cell counts in pulmonary venous blood (pvCTC) during surgical manipulation in non-small cell lung cancer

Abstract: Increasing pvCTC count during surgical manipulation was significantly correlated with postoperative distant metastasis in completely resected NSCLC patients. Significant shorter TDM was observed in patient with high ΔpvCTC group.

Cited by 31 publications

References 31 publications

Tumor‐proximal liquid biopsy to improve diagnostic and prognostic performances of circulating tumor cells

Tumor‐proximal liquid biopsy to improve diagnostic and prognostic performances of circulating tumor cells

Circulating tumor cells in the pulmonary vein increase significantly after lobectomy: A prospective observational study

Wedge Resection of Tumor Before Lobectomy for Lung Cancer Could Be a No-touch Isolation Technique

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