Positive correlation between TZAP and TERT in most cancers: a new player in cancer diseases

Heo, Yu‐Ran; Park, Won‐Jin; Lee, Jae-Ho

doi:10.21037/atm.2018.03.14

Cited by 7 publications

(9 citation statements)

References 4 publications

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“…In our previous report, quantitative correlation analysis also showed that TZAP and TERT mRNA levels were positively correlated in colon cancer ( r = 0.187, p < 0.001) and rectal cancer ( r = 0.186 p = 0.020). 20 Survival analysis showed that higher TZAP mRNA levels predicted poorer prognoses in colon cancer ( p < 0.001, Figure 5A ). However, it did not have any prognostic value in rectal cancer ( p = 0.119, Figure 5B ).…”

Section: Resultsmentioning

confidence: 99%

“…Our previous study using TCGA data showed this correlation in bladder, colorectal, glioblastoma, head and neck squamous cell carcinoma, hepatocellular carcinoma, lung, melanoma, and uterine endometrial carcinomas. 20 To confirm their association, TERT mRNA was analyzed in TZAP-silenced HCT116 and HT29 cells. The results showed that TZAP silencing decreased TERT mRNA expression in both cells.…”

Section: Discussionmentioning

confidence: 99%

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<p>Clinicopathological Characteristics of TZAP Expression in Colorectal Cancers</p>

Jung¹,

Seo²,

Park³

et al. 2020

OTT

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Purpose The zinc finger protein, ZBTB48, is a telomere-associated protein. It was renamed as telomeric zinc finger-associated protein (TZAP) binding to elongated telomeres. However, its expression level was not measured in cancers. Patients and Methods We analyzed TZAP mRNA levels in 60 colorectal cancers (CRC) and its correlation with telomere length and TERT was studied. Results TZAP mRNA in CRC was higher statistically than that in paired non-cancerous tissues (p = 0.033). Higher TZAP was found in carcinoembryonic antigen (CEA)-positive CRCs (>5 ng/mL) (p = 0.012). Shorter telomere was found in CRCs with high TZAP expression than that with low TZAP expression (p = 0.010). According to quantitative correlation analysis, TZAP has a correlation with age ( r = −0.349, p = 0.007), TERT ( r = 0.279, p = 0.041) and telomere length ( r = −0.305, p = 0.021). TZAP expression did not harbor prognostic value in CRC. Inhibition of TZAP expression by siRNA suppresses cell growth in HT29 cells; however, it resulted in increased cell viability in HCT116 cells. TZAP inhibition induces a decrease in mRNA levels of TERT in both HT29 and HCT116 cells. TCGA data analysis showed higher expression of TZAP showed poorer overall survival in colon cancer (p = 0.001); however, it did not have a significance in rectal cancer (p = 0.951). Conclusion We suggested that TZAP may be a possible biomarker for CRC.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

<p>Clinicopathological Characteristics of TZAP Expression in Colorectal Cancers</p>

Jung¹,

Seo²,

Park³

et al. 2020

OTT

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“…These mutations also resulted in a poorer survival, thereby supporting our results and hypothesis. We further demonstrated that TZAP expression was positively correlated with telomerase reverse transcriptase expression in various cancer types [8]. Moreover, TZAP appears to compete with telomeric repeat factors 1 and 2 in binding to telomeres.…”

Section: Discussionmentioning

confidence: 56%

“…A recent article introduced the zinc finger protein ZBTB48 (renamed as telomeric zinc finger-associated protein, TZAP), suggesting that its overexpression causes progressive telomere shortening [7]. While it indicated that genetic alterations of TZAP may influence cancer pathogenesis, smaller studies examining this have been performed in some cancers [8,9]. These studies suggested that insufficient TZAP expression or its disorder caused telomere elongation in immortal cancers cells, which predicted poorer prognosis.…”

Section: Introductionmentioning

confidence: 99%

Clinical and Prognostic Significance of TZAP Expression in Cervical Cancer

Park

Shin

et al. 2020

Medicina

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Background and Objectives: Telomeric zinc finger-associated protein (TZAP) is a telomere-associated factor that was previously called ZBTB48. This protein binds preferentially to long telomeres, competing with telomeric repeat factors 1 and 2. Genetic changes in TZAP may be associated with cancer pathogenesis; however, this relationship has not yet been elucidated for any type of cancer. In this study, we aimed to examine the clinicopathologic and prognostic value of TZAP expression in cervical cancer (CC). Materials and Methods: The data were extracted from The Cancer Genome Atlas cohorts by OncoLnc (21 cancer types, 7700 cancers). The prognostic value of TZAP for different stages of 264 CCs was examined using survival analysis. Results: The TZAP expression did not differ significantly between CC and normal matched tissues. Age, cancer stage, and viral infection were not associated with TZAP expression. Survival analysis revealed a shorter overall survival in CC patients with a lower TZAP expression (χ2 = 3.62, p = 0.057). The prognostic value of TZAP expression was greater in patients with N1 stage CC (χ2 = 5.64, p = 0.018). Conclusion: TZAP expression is a possible prognostic marker for CC, especially stage N1 CC.

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“…However, many studies demonstrated that the telomere length is an important factor for CRC prognosis [17][18][19]. Furthermore, our previous study reported a positive correlation between TERT and telomeric zinc-finger associated protein (TZAP) expression in colon and rectal cancers using The Cancer Genome Atlas (TCGA) database [20]. TZAP also has a great role for telomere regulation, however, its expression has not been studied in colorectal precancerous lesions and cancers.…”

Section: Discussionmentioning

confidence: 99%

Different TERT Expression between Colorectal Adenoma and Serrated Polyp

et al. 2020

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Background and Objectives: Telomere regulation have an association with colorectal cancer. Previous studies demonstrated its implication in colorectal carcinogenesis. This study aimed to identify the role of telomerase reverse transcriptase (TERT) in colorectal carcinogenesis and determine TERT expression and their associated genes in precancerous lesions. Materials and Methods: TERT expression in 93 colorectal precursor lesions was analyzed. This included 61 tubular adenomas (TAs) and 32 serrated polyps (SPs). Furthermore, KRAS and BRAF gene mutations and microsatellite instability were analyzed. Statistical tests were performed to analyze the relationship between variables. Results: TERT expression in TAs, when compared with those observed in paired adjacent nontumor tissues, was 0.92 ± 0.78. TERT expression levels were significantly lower in SPs (0.38 ± 0.14, p < 0.001). KRAS and BRAF mutations were mutually exclusive in TAs and SPs (p < 0.001). TERT expression tended to be associated with KRAS mutations (46.7% vs. 22.0%, p = 0.098) and low-grade tumors (35.0% vs. 16.0%, p = 0.096), but this difference was insignificant. Conclusions: TERT expression has a pivotal role in progression to TAs in colorectal tissue. Considering the association between TERT expression and KRAS mutation, therapeutic drugs targeting this pathway can be developed for cancer prevention.

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Positive correlation between TZAP and TERT in most cancers: a new player in cancer diseases

Cited by 7 publications

References 4 publications

<p>Clinicopathological Characteristics of TZAP Expression in Colorectal Cancers</p>

<p>Clinicopathological Characteristics of TZAP Expression in Colorectal Cancers</p>

Clinical and Prognostic Significance of TZAP Expression in Cervical Cancer

Different TERT Expression between Colorectal Adenoma and Serrated Polyp

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