Positive correlations between plasma BPI level and MPO-DNA and S100A8/A9 in myocardial infarction

Shicheng, Yu; Li, Miaonan; Li, Zheng; Xu, Pan; Yao, Zhuoya; Shaohuan, Qian; Fu, Qian; Da-sheng, Gao; Wang, Hongju

doi:10.1080/09537104.2021.1962836

Cited by 4 publications

(8 citation statements)

References 53 publications

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“…From these, 311 were duplicates, and after screening of unique reports based on title/abstract, 56 studies remained. These went through full‐text screening for data quality so that 20 high‐quality studies were included in our systematic review [ 14 , 23 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 ]. Figure 1 depicts the search details, reasons for exclusion, and a schematic diagram of the overall selection process.…”

Section: Resultsmentioning

confidence: 99%

“…The details of the included studies and their main findings are shown in Table 1 . Studies were mostly conducted in China, comprising nine of the 20 studies [ 32 , 35 , 38 , 40 , 42 , 43 , 44 , 45 , 46 ]. The included studies were published between 2006 and 2022.…”

Section: Resultsmentioning

confidence: 99%

“…A total of 4530 individuals were investigated in these studies, among which 3300 had CAD and 1230 were healthy controls. Thirteen studies evaluated calprotectin levels in serum [ 14 , 23 , 30 , 31 , 32 , 34 , 35 , 37 , 38 , 42 , 43 , 44 , 46 ], while six studies used plasma samples [ 33 , 36 , 39 , 40 , 45 , 47 ], and one of the studies evaluated both serum and plasma levels [ 41 ]. Details of the quality assessment results of these 20 studies are shown in Supporting Information S1: Table 2 .…”

Section: Resultsmentioning

confidence: 99%

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Circulating Levels of Calprotectin as a Biomarker in Patients With Coronary Artery Disease: A Systematic Review and Meta‐Analysis

Reshadmanesh,

Behnoush,

Farajollahi

et al. 2024

Clinical Cardiology

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BackgroundCalprotectin, also known as MRP8/14, is generated by immune cells and is altered in several inflammatory diseases. Studies have assessed their levels in patients with coronary artery disease (CAD) and its subtypes (stable CAD and acute coronary syndrome [ACS]). Herein, we aimed to systematically investigate these associations through a systematic review and meta‐analysis.MethodsA systematic search was conducted in four online databases, including PubMed, Scopus, Embase, and the Web of Science. Relevant studies were retrieved, screened, and extracted. Random‐effect meta‐analysis was performed for the calculation of standardized mean difference (SMD) and 95% confidence interval (CI). Blood calprotectin levels were compared between CAD patients and controls, as well as CAD subtypes.ResultsA total of 20 studies were included in the systematic review and meta‐analysis, comprising 3300 CAD patients and 1230 controls. Patients with CAD had significantly higher calprotectin levels (SMD 0.81, 95% CI 0.32−1.30, p < 0.01). Similarly, patients with ACS were reported to have higher levels compared to those with stable CAD. However, there was no significant difference in terms of blood calprotectin levels between stable CAD cases and healthy controls. Finally, studies have shown that calprotectin could be used as a diagnostic biomarker of CAD while also predicting major adverse events and mortality in these patients.ConclusionBased on our findings, calprotectin, as an inflammatory marker, could be used as a possible biomarker for patients with CAD and ACS. These suggest the possibility of pathophysiological pathways for this involvement and warrant further research on these associations as well as their clinical utility.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Circulating Levels of Calprotectin as a Biomarker in Patients With Coronary Artery Disease: A Systematic Review and Meta‐Analysis

Reshadmanesh,

Behnoush,

Farajollahi

et al. 2024

Clinical Cardiology

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“…Compared to healthy controls, the circulating levels of S100A8 increased more than two folds (18.69 vs. 8.11 ng/ml for acute myocardial infarction patients vs. healthy controls) (Pan et al, 2020). Notably, in acute myocardial infarction patients, the elevated serum levels of S100A8/A9 proteins correlated to multiple indicators of systemic inflammation, including peak neutrophil count, C‐reactive protein levels, as well as biomarkers of NETs (myeloperoxidase‐DNA, elastase) (Nagareddy et al, 2020; Yu et al, 2021). The greater S100A8/A9 protein levels are clinically associated with a poorer prognosis.…”

Section: The Implication Of S100a8/a9 Proteins In Heart Failurementioning

confidence: 99%

Pathogenic roles of neutrophil‐derived alarmins (S100A8/A9) in heart failure: From molecular mechanisms to therapeutic insights

Bai

Chen

2022

British J Pharmacology

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An excessive neutrophil count is recognized as a valuable predictor of inflammation and is associated with a higher risk of adverse cardiac events in patients with heart failure. Our understanding of the effectors used by neutrophils to inflict proinflammatory actions needs to be advanced. Recently, emerging evidence has demonstrated a causative role of neutrophil‐derived alarmins (i.e. S100A8/A9) in aggravating cardiac injuries by induction of inflammation. In parallel with the neutrophil count, high circulating levels of S100A8/A9 proteins powerfully predict mortality in patients with heart failure. As such, a deeper understanding of the biological functions of neutrophil‐derived S100A8/A9 proteins would offer novel therapeutic insights. Here, the basic biology of S100A8/A9 proteins and their pleiotropic roles in cardiovascular diseases are discussed, focusing on heart failure. We also consider the evidence that therapeutic targeting of S100A8/A9 proteins by the humanized vaccine, antibodies or inhibitors is able to town down inflammatory injuries.

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“…Stress-induced elevation of S100A8/A9 has been evidenced in patients with CAD with impaired cortisol response and is associated with poor prognosis in CAD patients (27). Recent studies have shown that S100A8/A9 is positively correlated with bactericidal/ permeability-increasing protein and is a potential biomarker of myocardial infarction in patients with acute myocardial infarction (28). In addition, some researchers found that HSP27 expression was increased in single nucleated cells of human peripheral blood and significantly correlated with the severity of CAD, rendering it a potential prognostic marker (29).…”

Section: Nk Cells Activated Mast Cells Resting T Cells Gamma Delta Ne...mentioning

confidence: 99%

Differential expression and significance of peripheral blood genes in coronary artery heart disease

Nong¹,

Ma²,

Luo³

et al. 2022

J Thorac Dis

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Background:The peripheral blood gene expression profile of patients with coronary artery disease (CAD) has not been fully resolved. The aim of this study was to further analyze the peripheral blood transcriptome information of CAD patients and to uncover key genes and regulatory mechanisms in the pathogenesis and disease progression of CAD. Methods:The Gene Expression Omnibus (GEO) database was applied to screen out differentially expressed genes (DEGs) in the peripheral blood of CAD patients, and the DEGs were subjected to Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), and gene set enrichment analysis (GSEA). The core genes were screened by GO, KEGG, and GSEA, and the gene-gene interaction (GGI) and protein-protein interaction (PPI) networks of DEGs were constructed. The GeneCards database was used to obtain CAD-related genes, and the GEO dataset was used to obtain intersecting genes. The intersecting genes were analyzed for bioenrichment and prediction of potential therapeutic agents, and predictive models were constructed for the intersecting genes. Finally, immune infiltrating cells from the GEO dataset were analyzed.Results: A total of 79 DEGs were screened in the peripheral blood of CAD patients, of which three were autophagy-related genes. Biological enrichment analysis showed that the DEGs were associated with metabolic pathways, and vascular smooth muscle contraction and were mainly involved the MAPK signaling pathway, metabolic pathways, and the PI3K-Akt signaling pathway. The S100A8, ENTPD1, and MMP9 further screened were screened. A total of 11 CAD crossover genes and 75 potential therapeutic agents were obtained, and the column line graph prediction models constructed for S100A8, HSPB1, F5, MMP9, and PDE9A had good predictive power. There were significant differences in immune cells in CAD patients compared to healthy individuals, especially in T cells regulatory (Tregs) and B cells naïve. Conclusions:The peripheral blood of CAD patients screened by the GEO dataset was significantly different from that of the healthy population, and the DEGs and intersecting genes were involved in numerous key biological processes that may be involved in the development and progression of CAD and could serve as its regulatory sites and therapeutic drug targets.

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Positive correlations between plasma BPI level and MPO-DNA and S100A8/A9 in myocardial infarction

Cited by 4 publications

References 53 publications

Circulating Levels of Calprotectin as a Biomarker in Patients With Coronary Artery Disease: A Systematic Review and Meta‐Analysis

Circulating Levels of Calprotectin as a Biomarker in Patients With Coronary Artery Disease: A Systematic Review and Meta‐Analysis

Pathogenic roles of neutrophil‐derived alarmins (S100A8/A9) in heart failure: From molecular mechanisms to therapeutic insights

Differential expression and significance of peripheral blood genes in coronary artery heart disease

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