Positive inotropic therapy: An update and new agents

Leier, Carl V.

doi:10.1016/s0146-2806(96)80002-8

Cited by 11 publications

(1 citation statement)

References 211 publications

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“…This consideration is important when comparing our results to other published studies evaluating mortality. Inotropic therapy in certain studies has been shown to have detrimental effects [ 5 , 10 , 26 – 36 ], although another meta-analysis was unable to confirm this view [ 37 ]. In ADHERE registry; more than 65,000 patients from 263 centers across the United States admitted with heart failure were retrospectively analyzed.…”

Section: Discussionmentioning

confidence: 99%

Inotropic agents use in patients hospitalized with acute decompensated heart failure: a retrospective analysis from a 22-year registry in a Middle-Eastern Country (1991–2013)

Aljundi

Mohammed

Patel

et al. 2016

BMC Cardiovasc Disord

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BackgroundData about the use of positive inotropic agents in patients hospitalized with acute decompensated heart failure (ADHF) is limited.MethodsThe records of 8066 patients with ADHF who were hospitalized at Hamad Medical Corporation, Qatar from 1991 to 2013 were analyzed to explore demographics and clinical characteristics of the patients according to inotropic agents use.ResultsEight hundred fifty eight patients [10.6 %, 95 % CI (10 to 11.3 %)] received intravenous inotropic support. Patients receiving inotropes were more likely to be female and have preserved ejection fraction when compared to those not receiving inotropic agents. Comorbidities associated with higher likelihood of receiving inotropic treatment included acute myocardial infarction, chronic renal impairment, dyslipidemia, hypertension, obesity and hyperglycemia. Patient on inotropes were more likely to undergone percutaneous coronary intervention (PCI), intra-aortic balloon pump support and intubation. There were no differences in the mean plasma BNP and CK-MB levels between the 2 groups. Heart failure patients receiving inotropes also were more likely to have complications including ventricular tachycardia (2.0 % vs. 0.9 %, p = 0.003), prolonged hospital stay (8.0 vs. 5.0 days, p = 0.001), cardiac arrest (14.6 % vs. 3.2 %, p = 0.001) and in-hospital mortality (30.8 % vs. 9.1 %, p = 0.001). Over the study period there was an increase use of inotropic agents and decreased mortality rates.ConclusionInotropic use increased over the period whereas; female gender and conventional cardiac risk factors were predictors of inotropic agents use in the study.

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