Positron Emission Mammographic Instrument: Initial Results

Murthy, K.; Aznar, Marianne C.; Bergman, Alanah; Thompson, Christopher J.; Robar, James L.; Lisbona, Robert; Loutfi, A; Gagnon, Jean H.

doi:10.1148/radiology.215.1.r00ap03280

Cited by 59 publications

(24 citation statements)

References 16 publications

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“…Lastly, DOI can be estimated from crystal arrays that have been engineered to provide depth-dependent scintillation light behavior. This can be done by segmenting the crystal block into different depth layers with different reflective coatings (18), by applying crystal light-sharing properties using different cutting patterns (19), or by looking at the second moment of the light distribution on monolithic crystal detectors (2).…”

Section: Detector Design Issuesmentioning

confidence: 99%

Breast-Dedicated Radionuclide Imaging Systems

2016

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Breast-dedicated radionuclide imaging systems show promise for increasing clinical sensitivity for breast cancer while minimizing patient dose and cost. We present several breast-dedicated coincidencephoton and single-photon camera designs that have been described in the literature and examine their intrinsic performance, clinical relevance, and impact. Recent tracer development is mentioned, results from recent clinical tests are summarized, and potential areas for improvement are highlighted. Br east cancer is the most common cancer in women worldwide, with 1.3 million cases diagnosed per year. The current standard of care in breast cancer management has challenges. Physical examinations often find palpable tumors that are already invasive and node-positive. Mammograms are well known for having low specificity and often being inconclusive for patients with dense breasts, leading to unnecessary surgical procedures and patient trauma. The use of noninvasive molecular imaging provides sensitive and specific cellular biologic information to aid in the diagnosis, staging, and treatment evaluation of breast cancer. PET and single-photon emission imaging have shown great diagnostic power in detection of malignant lesions in the body. The conventional systems sitting in the nuclear medicine clinic, however, are generalpurpose and have neither the photon sensitivity nor the spatial resolution required to affect earlier stages of breast cancer management. Technologic advances have enabled the creation of high-performance breast-dedicated (BD) radionuclide cameras that show promise for more sensitive cancer detection than standard clinical cameras while also providing better specificity than traditional anatomic imaging modalities such as x-ray mammography. This paper presents novel instrumentation from several different BD system designs that have been studied and evaluates the performance of different BD systems in the clinic. BD POSITRON EMISSION MAMMOGRAPHY (PEM) AND PET CAMERA DESIGNSSystem Configuration BD PET requires a field of view (FOV) large enough to be clinically relevant for breasts of all sizes, ranging from an average of 11.1-13.7 cm in diameter and 5.7-9.7 cm in length for bra cup sizes A-D (1). Detectors are typically arranged in a ring around the breast (annular systems), or in panels on 2 sides (dual-panel systems) or 4 sides (rectangular systems) of the breast. Translatable (2,3) and rotatable (4-7) detector heads can be used to extend the imaging FOV beyond the detector volume, but to date have had lower sensitivities than stationary systems with equivalent FOVs, and require longer scan times and more complex mechanical designs. For example, the sensitivity of the Shimadzu O-ring system is a factor of 5 higher than that of the Oncovision MAMMI system, which has a similar imaging FOV but uses translating heads (Table 1). Higher photon sensitivity generally allows for shorter scan times to achieve equivalent image quality, as seen with imaging protocols used for stationary (8) and translating systems ...

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Section: Detector Design Issuesmentioning

confidence: 99%

Breast-Dedicated Radionuclide Imaging Systems

2016

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“…An increasing number of PET cameras optimized to image the breast have been proposed or constructed [1][2][3][4][5][6][7][8][9]. These cameras, commonly known as Positron Emission Mammography or PEM cameras, restrict the field of view to a single breast, and are expected to have higher performance and lower cost than a conventional PET camera.…”

Section: Introductionmentioning

confidence: 99%

Instrumentation optimization for positron emission mammography

Moses

2004

Nuclear Instruments and Methods in Physics Research Section A:

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The past several years have seen designs for PET cameras optimized to image the breast, commonly known as Positron Emission Mammography or PEM cameras. The guiding principal behind PEM instrumentation is that a camera whose field of view is restricted to a single breast has higher performance and lower cost than a conventional PET camera. The most common geometry is a pair of parallel planes of detector modules, although geometries that encircle the breast have also been proposed. The ability of the detector modules to measure the depth of interaction (DOI) is also a relevant feature. This paper finds that while both the additional solid angle coverage afforded by encircling the breast and the decreased blurring afforded by the DOI measurement improve performance, the ability to measure DOI is more important than the ability to encircle the breast.

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“…A number of dedicated PET cameras optimized to image the breast have been proposed or constructed [1][2][3][4][5][6][7][8][9]. These cameras, commonly known as Positron Emission Mammography or PEM cameras, restrict the field of view to a single breast, and have higher performance and lower cost than a conventional PET camera.…”

Section: Introductionmentioning

confidence: 99%

Positron Emission Mammography imaging

Moses¹

2004

Nuclear Instruments and Methods in Physics Research Section A:

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This paper examines current trends in Positron Emission Mammography (PEM) instrumentation and the performance tradeoffs inherent in them. The most common geometry is a pair of parallel planes of detector modules. They subtend a larger solid angle around the breast than conventional PET cameras, and so have both higher efficiency and lower cost. Extensions to this geometry include encircling the breast, measuring the depth of interaction (DOI), and dual-modality imaging (PEM and x-ray mammography, as well as PEM and x-ray guided biopsy). The ultimate utility of PEM may not be decided by instrument performance, but by biological and medical factors, such as the patient to patient variation in radiotracer uptake or the as yet undetermined role of PEM in breast cancer diagnosis and treatment.

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Positron Emission Mammographic Instrument: Initial Results

Cited by 59 publications

References 16 publications

Breast-Dedicated Radionuclide Imaging Systems

Breast-Dedicated Radionuclide Imaging Systems

Instrumentation optimization for positron emission mammography

Positron Emission Mammography imaging

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