Positron Emission Tomography Imaging with 2-[18F]F-p-Aminobenzoic Acid Detects Staphylococcus aureus Infections and Monitors Drug Response

Zhang, Zhuo; Ordoñez, Alvaro A.; Wang, Hui; Li, Yong; Gogarty, Kayla R.; Weinstein, Edwin A.; Daryaee, Fereidoon; Merino, Jonathan; Yoon, Grace E.; Kalinda, Alvin S.; Mease, Ronnie C.; Iuliano, James N.; Smith‐Jones, Peter; Jain, Sanjay; Tonge, Peter J.

doi:10.1021/acsinfecdis.8b00182

Cited by 76 publications

(88 citation statements)

References 45 publications

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“…A radiofluorinated analogue of p-aminobenzoic acid (m-[ 18 F]-fluoro-PABA) (Scheme 7), which is a substrate for folic acid synthesis in prokaryotes [93], was evaluated in rats infected with methicillin-resistant or -sensitive S. aureus [94]. Bacteria use folic acid for their synthesis of nucleic acids.…”

Section: Imaging the Folic Acid Synthesis Pathwaymentioning

confidence: 99%

An update on radiotracer development for molecular imaging of bacterial infections

Welling

Hensbergen

Bunschoten

et al. 2019

Clin Transl Imaging

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Background Bacterial infections are still a major global healthcare problem. To combat the increasing antimicrobial resistance, early diagnosis of bacterial infections-including the identification of bacterial species-is needed to improve antibiotic stewardship and to help reduce the use of broad-spectrum antibiotics. To aid successful targeted antibiotic treatment, specific detection and localisation of infectious organisms is warranted. Nuclear medicine imaging approaches have been successfully used to diagnose bacterial infections and to differentiate between pathogen induced infections and sterile inflammatory processes. Aim In this comprehensive review we present an overview of recent developments in radiolabelled bacterial imaging tracers. Methods The PubMed/MEDLINE and Embase (OvidSP) literature databases were systematically searched for publications on SPECT and PET on specific imaging of bacterial using specific guidelines with MeSH-terms, truncations, and completion using cross-references. Tracers in literature that was extensively reviewed before 2016 were not included in this update. Where possible, the chemical structure of the radiolabelled compounds and clinical images were shown. Results In 219 original articles pre-clinical and clinical imaging of bacterial infection with new tracers were included. In our view, the highest translational potential lies with tracers that are specific to target the pathogens: e.g., 99m Tc-and 68 Galabelled UBI 29-41 , 99m Tc-vancomycin, m-[ 18 F]-fluoro-PABA, [methyl-11 C]-D-methionine, [ 18 F]-FDS, [ 18 F]-maltohexaose and [ 18 F]-maltotriose. An encouraging note is that some of these tracers have already been successfully evaluated in clinical settings. Conclusion This review summarises updates in tracer development for specific (pre-clinical and clinical) imaging of bacterial infections. We propsed some promising tracers that are likely to become innovative standards in the clinical setting in the near feature.

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Section: Imaging the Folic Acid Synthesis Pathwaymentioning

confidence: 99%

An update on radiotracer development for molecular imaging of bacterial infections

Welling

Hensbergen

Bunschoten

et al. 2019

Clin Transl Imaging

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“…The polymyxin B is an antibiotic, usually used for multidrug-resistant Gram-negative bacteria, that acts like an amphipathic antimicrobial peptide. Similarly, D-amino acids, molecules targeting the folate pathway in bacteria and siderophores have also been studied as bacterial specific imaging agents [34][35][36][37][38][39].…”

Section: Imaging Bacteria In Animal Modelsmentioning

confidence: 99%

Imaging Bacteria with Radiolabelled Probes: Is It Feasible?

Artiko

Conserva

Ferro-Flores

et al. 2020

JCM

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Bacterial infections are the main cause of patient morbidity and mortality worldwide. Diagnosis can be difficult and delayed as well as the identification of the etiological pathogen, necessary for a tailored antibiotic therapy. Several non-invasive diagnostic procedures are available, all with pros and cons. Molecular nuclear medicine has highly contributed in this field by proposing several different radiopharmaceuticals (antimicrobial peptides, leukocytes, cytokines, antibiotics, sugars, etc.) but none proved to be highly specific for bacteria, although many agents in development look promising. Indeed, factors including the number and strain of bacteria, the infection site, and the host condition, may affect the specificity of the tested radiopharmaceuticals. At the Third European Congress on Infection/Inflammation Imaging, a round table discussion was dedicated to debate the pros and cons of different radiopharmaceuticals for imaging bacteria with the final goal to find a consensus on the most relevant research steps that should be fulfilled when testing a new probe, based on experience and cumulative published evidence.

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“…PET study with m-[18F]-fluoro-PABA showed rapid uptake in bacterial infections (core to muscle ratio ≈ 8) and low uptake in sterile inflammation (about nine times lower), which meant that this radiopharmaceutical can be considered as specific for imaging bacterial infections. m-[18F]-fluoro-PABA showed reduced uptake in tissues infected with Staphylococcus aureus treated with oxacillin, indicating the possibility of using this radiopharmaceutical also to monitor response to treatment [42].…”

Section: Future Directionsmentioning

confidence: 99%