Positron Emission Tomography in Heart Failure: From Pathophysiology to Clinical Application

Tersalvi, Gregorio; Beltrani, Vincent S.; Grübler, Martin; Molteni, Alessandra; Cristoforetti, Yvonne; Pedrazzini, Giovanni; Treglia, Giorgio; Biasco, Luigi

doi:10.3390/jcdd10050220

Cited by 2 publications

(1 citation statement)

References 143 publications

(187 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Positron emission tomography (PET) is a sensitive technique to study physiology, metabolism, and molecular pathways in living humans using labeled endogenous and natural exogenous compounds (Tersalvi et al, 2023;Toyama et al, 2021;Amoabeng et al, 2022). The ketone radiotracer 11 C-acetoacetate ( 11 C-AcAc) was developed to assess brain ketone metabolism in conditions such as mild cognitive impairment and Alzheimer's disease (Croteau et al, 2018), which are characterized by regional brain glucose hypometabolism but with preserved brain ketone metabolism (Cunnane et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Cardiorenal ketone metabolism: a positron emission tomography study in healthy humans

Cuenoud,

Croteau,

St-Pierre

et al. 2023

Front. Physiol.

View full text Add to dashboard Cite

Ketones are alternative energy substrates for the heart and kidney but no studies have investigated their metabolism simultaneously in both organs in humans. The present double tracer positron emission tomography (PET) study evaluated the organ distribution and basal kinetic rates of the radiolabeled ketone, 11C-acetoacetate (11C-AcAc), in the heart and kidney compared to 11C-acetate (11C-Ac), which is a well-validated metabolic radiotracer. Both tracers were highly metabolized by the left ventricle and the renal cortex. In the heart, kinetic rates were similar for both tracers. But in the renal cortex, uptake of 11C-Ac was higher compared to 11C-AcAc, while the reverse was observed for the clearance. Interestingly, infusion of 11C-AcAc led to a significantly delayed release of radioactivity in the renal medulla and pelvis, a phenomenon not observed with 11C-Ac. This suggests an equilibrium of 11C-AcAc with the other ketone, 11C-D-beta-hydroxybutyrate, and a different clearance profile. Overall, this suggests that in the kidney, the absorption and metabolism of 11C-AcAc is different compared to 11C-Ac. This dual tracer PET protocol provides the opportunity to explore the relative importance of ketone metabolism in cardiac and renal diseases, and to improve our mechanistic understanding of new metabolic interventions targeting these two organs.

show abstract

Section: Introductionmentioning

confidence: 99%

Cardiorenal ketone metabolism: a positron emission tomography study in healthy humans

Cuenoud,

Croteau,

St-Pierre

et al. 2023

Front. Physiol.

View full text Add to dashboard Cite

show abstract

Heart Failure: A Deficiency of Energy—A Path Yet to Discover and Walk

Paraskevaidis,

Kourek,

Farmakis

et al. 2024

Biomedicines

View full text Add to dashboard Cite

Heart failure is a complex syndrome and our understanding and therapeutic approach relies mostly on its phenotypic presentation. Notably, the heart is characterized as the most energy-consuming organ, being both a producer and consumer, in order to satisfy multiple cardiac functions: ion exchange, electromechanical coordination, excitation–contraction coupling, etc. By obtaining further knowledge of the cardiac energy field, we can probably better characterize the basic pathophysiological events occurring in heart disease patients and understand the metabolic substance changes, the relationship between the alteration of energy production/consumption, and hence energetic deficiency not only in the heart as a whole but in every single cardiac territory, which will hopefully provide us with the opportunity to uncover the beginning of the heart failure process. In this respect, using (a) newer imaging techniques, (b) biomedicine, (c) nanotechnology, and (d) artificial intelligence, we can gain a deeper understanding of this complex syndrome. This, in turn, can lead to earlier and more effective therapeutic approaches, ultimately improving human health. To date, the scientific community has not given sufficient attention to the energetic starvation model. In our view, this review aims to encourage scientists and the medical community to conduct studies for a better understanding and treatment of this syndrome.

show abstract

Positron Emission Tomography in Heart Failure: From Pathophysiology to Clinical Application

Cited by 2 publications

References 143 publications

Cardiorenal ketone metabolism: a positron emission tomography study in healthy humans

Cardiorenal ketone metabolism: a positron emission tomography study in healthy humans

Heart Failure: A Deficiency of Energy—A Path Yet to Discover and Walk

Contact Info

Product

Resources

About