Possibilities and Limitations for Reversal of Age-Related Hair Loss

Otberg, Nina; Restrepo, Isabel; Shapiro, Jerry

doi:10.1007/978-3-642-02636-2_18

Cited by 2 publications

(1 citation statement)

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“…Once hair loss becomes apparent, significant loss has already occurred. While there are potentially successful drug treatments to reverse hair loss [4][5][6], prevention of initial loss is likely a more effective means of maintaining hair amount through aging. One key factor in loss prevention is providing optimal scalp conditions for hair to grow, be optimally retained and replaced after normal shedding [7].…”

Section: Introductionmentioning

confidence: 99%

Follicular Delivery of Caffeine from a Shampoo for Hair Retention

et al. 2023

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A key factor in the prevention of hair loss is the provision of optimal conditions on the scalp. In this regard, reduction of oxidative stress on the scalp is one critical requirement to support the hair follicles to function optimally. Recently, a novel shampoo formulation technology containing anti-oxidants such as piroctone olamine has been demonstrated to improve hair retention based on micellar degradation and coacervation effects. Caffeine has also been shown to exhibit anti-oxidant activity including the ability to inhibit lipid peroxidation. As with piroctone olamine, it is expected that follicular delivery of caffeine will enhance its anti-oxidant activity in a region that will be beneficial for hair retention. In this study, two shampoo formulations as well as a control formulation were applied to the calf area of n = 9 male participants. The technique of differential tape stripping was applied to obtain the caffeine penetrated to the stratum corneum and to the hair follicles. Isotope-dilution liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) was performed to demonstrate caffeine follicular delivery from the shampoo formulas. The results showed that the percentage of caffeine recovered in the hair follicles was 8–9% of the caffeine absorbed into the skin and matched an existing caffeine-based shampoo. In conclusion, a novel shampoo formulation technology has been developed that effectively delivers beneficial anti-oxidants to improve hair retention. This new shampoo is expected to be especially useful in the goal of retaining hair during aging.

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