Possibilities and limitations of solution-state NMR spectroscopy to analyze the ligand shell of ultrasmall metal nanoparticles

Wolff, Natalie; Beuck, Christine; Schaller, Torsten; Epple, Matthias

doi:10.1039/d4na00139g

Nanoscale Adv.

2024

DOI: 10.1039/d4na00139g

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Possibilities and limitations of solution-state NMR spectroscopy to analyze the ligand shell of ultrasmall metal nanoparticles

Natalie Wolff,

Christine Beuck,

Torsten Schaller

et al.

Abstract: Ultrasmall nanoparticles have a diameter between 1-3 nm at the border between nanoparticles and large molecules. Usually, their core consists of a metal, and their shell of a capping ligand...

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Cited by 2 publications

References 131 publications

(253 reference statements)

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Effect of solvent chain length on the colloidal behavior of alkylamine-protected silver nanoparticles in alkanes: Insights from solvent relaxation NMR

Yasukawa,

Manyuan,

Ikeda

et al. 2025

Journal of Colloid and Interface Science

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Effect of solvent chain length on the colloidal behavior of alkylamine-protected silver nanoparticles in alkanes: Insights from solvent relaxation NMR

Yasukawa,

Manyuan,

Ikeda

et al. 2025

Journal of Colloid and Interface Science

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Increased Cytotoxicity of Bimetallic Ultrasmall Silver–Platinum Nanoparticles (2 nm) on Cells and Bacteria in Comparison to Silver Nanoparticles of the Same Size

Wolff,

Białas,

Loza

et al. 2024

Materials

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Ultrasmall nanoparticles (diameter 2 nm) of silver, platinum, and bimetallic nanoparticles (molar ratio of Ag:Pt 0:100; 20:80; 50:50; 70:30; 100:0), stabilized by the thiolated ligand glutathione, were prepared and characterized by transmission electron microscopy, differential centrifugal sedimentation, X-ray photoelectron spectroscopy, small-angle X-ray scattering, X-ray powder diffraction, and NMR spectroscopy in aqueous dispersion. Gold nanoparticles of the same size were prepared as control. The particles were fluorescently labeled by conjugation of the dye AlexaFluor-647 via copper-catalyzed azide-alkyne cycloaddition after converting amine groups of glutathione into azide groups. All nanoparticles were well taken up by HeLa cells. The cytotoxicity was assessed with an MTT test on HeLa cells and minimal inhibitory concentration (MIC) tests on the bacteria Escherichia coli and Staphylococcus xylosus. Notably, bimetallic AgPt nanoparticles had a higher cytotoxicity against cells and bacteria than monometallic silver nanoparticles or a physical mixture of silver and platinum nanoparticles. However, the measured release of silver ions from monometallic and bimetallic silver nanoparticles in water was very low despite the ultrasmall size and the associated high specific surface area. This is probably due to the surface protection by a dense layer of thiolated ligand glutathione. Thus, the enhanced cytotoxicity of bimetallic AgPt nanoparticles is caused by the biological environment in cell culture media, together with a polarization of silver by platinum.

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Possibilities and limitations of solution-state NMR spectroscopy to analyze the ligand shell of ultrasmall metal nanoparticles

Abstract: Ultrasmall nanoparticles have a diameter between 1-3 nm at the border between nanoparticles and large molecules. Usually, their core consists of a metal, and their shell of a capping ligand...

Cited by 2 publications

References 131 publications

Effect of solvent chain length on the colloidal behavior of alkylamine-protected silver nanoparticles in alkanes: Insights from solvent relaxation NMR

Effect of solvent chain length on the colloidal behavior of alkylamine-protected silver nanoparticles in alkanes: Insights from solvent relaxation NMR

Increased Cytotoxicity of Bimetallic Ultrasmall Silver–Platinum Nanoparticles (2 nm) on Cells and Bacteria in Comparison to Silver Nanoparticles of the Same Size

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