Possible application of H2S-producing compounds in therapy of coronavirus (COVID-19) infection and pneumonia

Евгеньев, М. Б.; Frenkel, Anton

doi:10.1007/s12192-020-01120-1

Cited by 35 publications

(40 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The gasotransmitters NO and H 2 S have overlapping pathophysiological roles with significant influence in regulating cardio– and vaso– protective functions and possessing anti-inflammatory, anti-thrombotic, and antiviral properties[ 7 , [18] , [19] , [20] , [21] ]. While researchers have pondered the possible use of NO and H 2 S in the treatment of COVID-19, studies exploring the availability of these two gasotransmitters in COVID-19 patients are limited[ 11 , 13 , 14 , [22] , [23] , [24] ]. For the first time, our study analyzed and compared both NO and sulfide metabolites in healthy subjects and COVID-19 patients and observed a significant and parallel reduction in both NO and sulfide metabolites in the COVID-19 patients compared to controls ( Fig.…”

Section: Discussionmentioning

confidence: 99%

“…H 2 S is another gasotransmitter with antiviral properties that is cardioprotective, anti-inflammatory, and antioxidant [ 8 , 29 , 30 ]. Considering its varied functions, it has been contemplated as a possible therapy in COVID-19 infection [ 11 , 22 , 31 ]. We have previously reported H 2 S availability as a predictive biomarker for cardiovascular disease in a race- and sex-based manner [ 16 ].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Decreased availability of nitric oxide and hydrogen sulfide is a hallmark of COVID-19

et al. 2021

View full text Add to dashboard Cite

Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is involved in a global outbreak affecting millions of people who manifest a variety of symptoms. Coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 is increasingly associated with cardiovascular complications requiring hospitalizations; however, the mechanisms underlying these complications remain unknown. Nitric oxide (NO) and hydrogen sulfide (H 2 S) are gasotransmitters that regulate key cardiovascular functions. Methods Blood samples were obtained from 68 COVID-19 patients and 33 controls and NO and H 2 S metabolites were assessed. H 2 S and NO levels were compared between cases and controls in the entire study population and subgroups based on race. The availability of gasotransmitters was examined based on severity and outcome of COVID-19 infection. The performance of H 2 S and NO levels in predicting COVID-19 infection was also analyzed. Multivariable regression analysis was performed to identify the effects of traditional determinants of gasotransmitters on NO and H 2 S levels in the patients with COVID-19 infection. Results Significantly reduced NO and H 2 S levels were observed in both Caucasian and African American COVID-19 patients compared to healthy controls. COVID-19 patients who died had significantly higher NO and H 2 S levels compared to COVID-19 patients who survived. Receiver-operating characteristic analysis of NO and H 2 S metabolites in the study population showed free sulfide levels to be highly predictive of COVID-19 infection based on reduced availability. Traditional determinants of gasotransmitters, namely age, race, sex, diabetes, and hypertension had no effect on NO and H 2 S levels in COVID-19 patients. Conclusion These observations provide the first insight into the role of NO and H 2 S in COVID-19 infection, where their low availability may be a result of reduced synthesis secondary to endotheliitis, or increased consumption from scavenging of reactive oxygen species.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Decreased availability of nitric oxide and hydrogen sulfide is a hallmark of COVID-19

et al. 2021

View full text Add to dashboard Cite

show abstract

“…The compounds releasing H 2 S have anti inflammatory and antiviral activities against a wide range of pathogenic viruses [43]. A review paper has recently been published justifying the use of inhaled form of sodium thiosulphate for patients with COVID 19 infection [44].…”

Section: Discussionmentioning

confidence: 99%

Transcription Factor Nrf2 as a Potential Therapeutic Target for Prevention of Cytokine Storm in COVID-19 Patients

Zinovkin

Гребенчиков

2020

Biochemistry Moscow

View full text Add to dashboard Cite

Nrf2 is a key transcription factor responsible for antioxidant defense in many tissues and cells, including alveolar epithelium, endothelium, and macrophages. Furthermore, Nrf2 functions as a transcriptional repressor that inhibits expres sion of the inflammatory cytokines in macrophages. Critically ill patients with COVID 19 infection often present signs of high oxidative stress and systemic inflammation-the leading causes of mortality. This article suggests rationale for the use of Nrf2 inducers to prevent development of an excessive inflammatory response in COVID 19 patients.

show abstract

“…Moreover, preliminary studies point to a role of H 2 S in regulating the host response to viral infections (Yang, 2020). Such evidence provides a strong case for the potential antiviral benefits offered by different classes and chemotypes of H 2 S donor molecules as therapeutic agents, as recently proposed also by other pioneering hypotheses (Evgen'ev & Frenkel, 2020;Yang, 2020). Several compounds already in clinical development for other therapeutic indications, such as SG1002 or sulforaphane, can be viewed as potential high-value candidates for rapid repurposing for antiviral therapy against COVID-19.…”

Section: Discussionmentioning

confidence: 66%

Anti‐inflammatory and antiviral roles of hydrogen sulfide: Rationale for considering H₂S donors in COVID‐19 therapy

Citi

Martelli

Brancaleone

et al. 2020

British J Pharmacology

View full text Add to dashboard Cite

The COVID-19 pandemic caused by SARS-Cov-2 demands rapid, safe and effective therapeutic options. In the last decades, the endogenous gasotransmitter hydrogen sulfide (H 2 S) has emerged as modulator of several biological functions and its deficiency has been associated with different disorders. Therefore, many H 2 S-releasing agents have been developed as potential therapeutic tools for diseases related with impaired H 2 S production and/or activity. Some of these compounds are in advanced clinical trials. Presently, the pivotal role of H 2 S in modulating the inflammatory response and pro-inflammatory cytokine cascade is well recognized, and the usefulness of some H 2 S-donors for the treatment of acute lung inflammation has been reported. Recent data is elucidating several mechanisms of action, which may account for antiviral effects of H 2 S. Noteworthy, some preliminary clinical results suggest an inverse relationship between endogenous H 2 S levels and severity of COVID-19. Therefore, repurposing of H 2 S-releasing drugs may be a potential therapeutic opportunity for treatment of COVID-19.

show abstract

Possible application of H2S-producing compounds in therapy of coronavirus (COVID-19) infection and pneumonia

Cited by 35 publications

References 24 publications

Decreased availability of nitric oxide and hydrogen sulfide is a hallmark of COVID-19

Decreased availability of nitric oxide and hydrogen sulfide is a hallmark of COVID-19

Transcription Factor Nrf2 as a Potential Therapeutic Target for Prevention of Cytokine Storm in COVID-19 Patients

Anti‐inflammatory and antiviral roles of hydrogen sulfide: Rationale for considering H₂S donors in COVID‐19 therapy

Contact Info

Product

Resources

About

Possible application of H2S-producing compounds in therapy of coronavirus (COVID-19) infection and pneumonia

Cited by 35 publications

References 24 publications

Decreased availability of nitric oxide and hydrogen sulfide is a hallmark of COVID-19

Decreased availability of nitric oxide and hydrogen sulfide is a hallmark of COVID-19

Transcription Factor Nrf2 as a Potential Therapeutic Target for Prevention of Cytokine Storm in COVID-19 Patients

Anti‐inflammatory and antiviral roles of hydrogen sulfide: Rationale for considering H2S donors in COVID‐19 therapy

Contact Info

Product

Resources

About

Anti‐inflammatory and antiviral roles of hydrogen sulfide: Rationale for considering H₂S donors in COVID‐19 therapy