Possible mechanisms of allergic reactions of the skeletal muscle

Abstract

The effects of denervation and sensitization alone and in combination on the isometric contractions of guinea pig diaphragmal muscle are studied in vitro. Denervated diaphragmal muscle contracts in response to histamine, the reaction being abolished by the histamine receptor blocker dimedrol. After sensitization, these muscles respond to histamine and specific antigen, contraction being prevented by incubation with dimedrol and the mast cell blocker Intal. The possible mechanisms of reactions in the muscles are discussed.