Possible Protective Effect of Ginger Extract and Beetroot Juice Against Cisplatin Induced Testicular and Cytogenetic Toxicity in Adult Male Albino Rats

Elshiekh, Asmaa A.; Elkolaly, Hala R.; Tawfeek, Noura M.; Mohamed, Amira A.; Mohamed, Aml

doi:10.21608/ejhm.2019.42298

Cited by 7 publications

(3 citation statements)

References 15 publications

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“…Cistreated rats demonstrated a drop in testosterone levels, which was consistent with earlier research [26,27]. This reduction in the hormonal level may be explained by two theories, that Cis induced severe damages on Leydig and Sertoli cells resulting from the increased generation of ROS [28] , or it may occur through interference with LH receptor expression and FSH [29]. according to our findings EA administration definitely alters sperm parameters and total sexual hormone function, and can also increase the spermatogenesis rate in animals with damaged sperm.…”

Section: A B Csupporting

confidence: 86%

Ameliorative effects of Ellagic acid against toxicity of cisplatin in male rats

Abdelsalam

2022

Bulletin of Faculty of Science, Zagazig University

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Cisplatin (Cis) is a regularly used medicine to treat cancer, particularly breast cancer, however it has adverse effects that impact other bodily systems. The goal of this study is to employ Ellagic acid (Ell) to reduce the drug's side effects. A total of forty male albino rats are randomly allocated into four groups: Control, Cis, Cis+Ell, and Ell acid. Serum lipid profile and sexual hormones (FSH, LH, and testosterone) were measured biochemically, and liver slices from all groups were processed for histological analysis. Our findings demonstrated that following Cis administration, Ell treatment resulted in significant improvements in all biochemical parameters, with Ell causing considerable reductions in cholesterol, triglycerides, and LDL while increasing HDL levels. Ell induced a considerable increase in the concentrations of FSH, LH, and testosterone in the Cis+Ell group, despite Cis dramatically lowering these levels in the second group. Ell can promote a great recovery in the hepatic architecture following a Cis-induced deformation, according to histopathological analysis. Finally, Ell therapy can help to mitigate the harmful effects of Cis delivery.

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Section: A B Csupporting

confidence: 86%

Ameliorative effects of Ellagic acid against toxicity of cisplatin in male rats

Abdelsalam

2022

Bulletin of Faculty of Science, Zagazig University

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“…Betanin significantly attenuates cisplatin-induced testicular toxicity in rats by lowering MDA, with increasing GSH and CAT levels compared to the control animals [49][50] Wistar rats 300 mg/kg beetroot extract…”

Section: Male Albino Rats Different Doses Of Red Beetroot (Rbr) Extractmentioning

confidence: 95%

“…An investigation of the histopathology of cisplatin-induced testicular damage in rats and the healing effect of beetroot extract by Hassen et al [50] identified a considerable reduction in IL-6, MDA (as ascribed to ROS surplus that attacks the cell membrane), iNOS gene mRNA levels, and slightly elevated GSH and total antioxidant capacity (TAC) in rats by beetroot extract. This indicates suppression of the inflammatory response cell and upregulation of antioxidant activity [49] . Similarly, Albasher et al [20] observed that beetroot extract pretreatment reduced MDA, NO, IL-1β, TNF-α and IL-6, and Nos2 mRNA, while boosting the Nrf2/ARE (antioxidant response element) pathway and scavenging activity in chlorpyrifos-exposed testicular tissue via NF-κB inactivation.…”

Section: Repro-protective Effectmentioning

confidence: 97%

Betalains protect various body organs through antioxidant and anti-inflammatory pathways

Prakash¹,

Medhe²,

Dahal³

et al. 2024

Food Science and Human Wellness

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Betalains are natural coloring pigments with betalamic acid as the core structure of all subclasses. Besides their coloring properties, betalains exhibit various biological activities, including antioxidant and anti-inflammatory properties, which are highly imperative. Further in-vivo studies reported that betalains protect various body organs, leading to health enhancement. Body organs, including the heart, liver, kidney, lung, etc., are important for a healthy life. However, these organs can be affected or damaged by various stress factors, toxicants, and harmful substances. Recent studies have claimed that betalains could protect all vital organs of the body through antioxidant and anti-inflammatory mechanisms. This review article described the in-vivo antioxidant and anti-infl ammatory activities of betalains in various cell-line or animal models. A comprehensive discussion has been provided on the mechanism of action of betalains in protecting various body organs, including cardio-protective effect, hepato-protective ability, renal protection capacity, repro-protective ability, neuro-protective effect, lung protection, and gut protection ability. Finally, future research directions and conclusions have been outlined.

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