Possible relationship between mitochondrial DNA polymorphisms and lithium response in bipolar disorder

Washizuka, Shinsuke; Ikeda, Akifumi; Kato, Nobuo; Kato, Takeshi

doi:10.1017/s1461145703003778

Cited by 48 publications

(34 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…They reported a significant association between the C5178A polymorphism and extraversion in healthy controls (n = 238). A separate study suggested the mtDNA A10398G polymorphism of the MT-ND3 genes may be related to lithium response in BPD (90).…”

Section: Munakata Et Al (2005)mentioning

confidence: 99%

Mitochondrial involvement in psychiatric disorders

et al. 2008

View full text Add to dashboard Cite

Recent findings of mitochondrial abnormalities in brains from subjects with neurological disorders have led to a renewed search for mitochondrial abnormalities in psychiatric disorders. A growing body of evidence suggests that there is mitochondrial dysfunction in schizophrenia, bipolar disorder, and major depressive disorder, including evidence from electron microscopy, imaging, gene expression, genotyping, and sequencing studies. Specific evidence of dysfunction such as increased common deletion and decreased gene expression in mitochondria in psychiatric illnesses suggests that direct examination of mitochondrial DNA from postmortem brain cells may provide further details of mitochondrial alterations in psychiatric disorders.

show abstract

Section: Munakata Et Al (2005)mentioning

confidence: 99%

Mitochondrial involvement in psychiatric disorders

et al. 2008

View full text Add to dashboard Cite

show abstract

“…29 The cornerstone of the GABA hypothesis of bipolar disorder is that GABA provides an inhibitory action to both norepinephrine and dopamine systems. 30 Although this widely expressed neurotransmitter has been thought to exert a tonic inhibitory effect on norepinephrine systems, an earlier study 31 suggests that GABA may in fact facilitate norepinephrine activity. It also reported that plasma GABA levels are relatively reduced in depressed patients.…”

Section: Discussionmentioning

confidence: 99%

Combination of valproate and paroxetine in mice exposed to picrotoxin

Kamal¹

2012

IJN

View full text Add to dashboard Cite

Abstract:The frequent coexistence of depression in epileptic patients raises the issue of simultaneous use of antidepressants along with antiepileptic drugs in the management of such cases. However, it is necessary to evaluate the safety of these antiepileptic/antidepressant drug combinations. The present study investigates the effect of the antidepressant paroxetine (a selective serotonin reuptake inhibitor) administered alone or in combination with the antiepileptic drug sodium valproate on chemoconvulsions induced by picrotoxin (PTX). Seizure score was recorded in vivo, and the levels of thiobarbituric acid-reactive substances and gamma aminobutyric acid (GABA) were measured in the nucleus accumbens of the tested groups of mice. The results show enhancement of seizure severity with significant reduction in GABA levels upon PTX treatment that were reversed by its combination with sodium valproate. On the other hand, paroxetine administered in combination with sodium valproate provided significant protection against PTX-induced convulsions as well as a significant increase in GABA levels in selected brain areas. These results favor their application in management of epilepsy-depression comorbidities.

show abstract

“…Among those candidate genes, the tryptophan hydroxylase C allele (TPH), 73 the phospholipase C g-1 gene (PLCG1) repeat, 74,75 the C973A polymorphism in the inositol polyphosphate 1-phosphatase 76 and the mitochondrial DNA (mtDNA) 10398 polymorphism, 77 have been suggested as being associated with positive lithium response.…”

Section: Discussionmentioning

confidence: 99%

Further evidence for a possible association between serotonin transporter gene and lithium prophylaxis in mood disorders

et al. 2004

View full text Add to dashboard Cite

We previously reported an association between the functional polymorphism in the upstream regulatory region of the serotonin transporter gene (SERTPR) and the prophylactic efficacy of lithium in a sample of 201 Italian subjects affected by Mood disorders. The aim of the present study was to replicate analyses on an independent sample. In total, 83 subjects affected by Bipolar disorder were recruited in the Mood Disorders Clinic of the Eginition Hospital of the Athens University, Medical School Department of Psychiatry. All patients were administered with lithium as prophylactic therapy and they were prospectively observed for at least 3 years. Subjects were typed for their SERTPR variant using polymerase chain reaction techniques. SERTPR variants were associated with lithium outcome among those subjects who had few manic episodes before lithium treatment and, as a trend, among subjects who received a high daily dose of lithium (X1200 mg/die). In both cases, subjects with the l/l variant showed a higher probability to develop an illness episode within 3 years of prophylactic treatment with lithium. The present study confirmed our previous observation of a better response of SERTPR*l/s carriers, but could not confirm a poor efficacy in subjects with the SERTPR*s/s genotype. Notwithstanding the conflicting results, SERTPR variants are a possible liability factor for lithium long-term efficacy in mood disorders. Further studies on independent and large samples are required to determine the reliability and direction of the possible association between SERTPR variants and lithium outcome. INTRODUCTIONLithium is an effective prophylactic agent in mood disorders but not all patients equally respond to lithium therapy. Clinical predictors account for less than half of the variance, 1-8 and there are evidences suggesting that genetic factors play a substantial role in lithium prophylaxis effectiveness. [9][10][11][12][13][14][15][16][17][18][19][20] A large number of studies reported an association between prophylactic lithium response and a family history of bipolar disorder, 10,[12][13][14]17 although not unequivocally confirmed. [21][22][23][24][25] Recently, Grof et al 26 reported that lithium response in a sample of relatives of responder probands was 67% compared to 30% in the comparison group.

show abstract

Possible relationship between mitochondrial DNA polymorphisms and lithium response in bipolar disorder

Cited by 48 publications

References 19 publications

Mitochondrial involvement in psychiatric disorders

Mitochondrial involvement in psychiatric disorders

Combination of valproate and paroxetine in mice exposed to picrotoxin

Further evidence for a possible association between serotonin transporter gene and lithium prophylaxis in mood disorders

Contact Info

Product

Resources

About