Possible roles of platelet-derived microparticles in atherosclerosis

Wang, Zhiting; Wang, Zi; Hu, Yan‐Wei

doi:10.1016/j.atherosclerosis.2016.03.004

Cited by 71 publications

(59 citation statements)

References 76 publications

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“…Atherosclerosis is a chronic inflammatory process that is characterized by deposition of fibrous tissues and fat in the intima of elastic arteries, resulting in thrombus formation and structural damage, characterized by thickening and hardening of the vessel walls, followed by loss of elasticity and narrowing of the lumen . There are four main pathological criteria for atherosclerosis: (i) the formation of “fatty streaks” that reduce the elasticity of arterial walls; (ii) fibrous plaques; (iii) atheromatous plaques; and (iv) thrombosis.…”

Section: Introductionmentioning

confidence: 99%

Intestinal fatty acid binding protein Ala54Thr polymorphism is associated with peripheral atherosclerosis combined with type 2 diabetes mellitus

Khattab

Abo-Elmatty

Ghattas

et al. 2016

Journal of Diabetes

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Background: Intestinal fatty acid-binding protein 2 (FABP2) is expressed in enterocytes and binds saturated and unsaturated long-chain fatty acids. The FABP2 Ala54Thr polymorphism has been reported to effect lipid metabolism. The aim of the present study was to assess the relationship between this polymorphism and peripheral atherosclerosis combined with type 2 diabetes mellitus (T2DM) in an Egyptian population. Methods: The study was performed on 100 T2DM patients with peripheral atherosclerosis and 100 control subjects. The Ala54Thr polymorphism was analyzed by polymerase chain reaction-restriction fragment length polymorphism, whereas serum FABP2 levels were determined using ELISA. Fasting blood glucose, fasting serum insulin concentrations, HbA1c, lipid profile, body mass index (BMI) and systolic and diastolic blood pressure (SBP and DBP, respectively) were determined. Results: There was a higher frequency of the Thr54 allele among the patient group (P = 0.002). In Ala54/Thr54 heterozygotes and carriers of the rare Thr54/Thr54 genotype, there were significant increases in BMI and FABP2. Those with the Thr54/Thr54 genotype had significantly decreased high-density lipoprotein cholesterol (HDL-C) concentrations; in addition, those with the Thr54/Thr54 genotype had significantly higher SBP and DBP than subjects with the Ala54/Ala54 and Ala54/Thr54 genotypes. There was a positive correlation between FABP2 levels and BMI, SBP and DBP, and a negative correlation with HDL-C. Conclusions: The Thr54 allele of the FABP2 Ala54Thr polymorphism was associated with an increased incidence of peripheral atherosclerosis combined with T2DM in the population studied.

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Section: Introductionmentioning

confidence: 99%

Intestinal fatty acid binding protein Ala54Thr polymorphism is associated with peripheral atherosclerosis combined with type 2 diabetes mellitus

Khattab

Abo-Elmatty

Ghattas

et al. 2016

Journal of Diabetes

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“…15 One of the most intriguing recent developments is the notion that local action of platelet microvesicles (commonly 100-200 nm in size) promotes vascular inflammation and lipid accumulation and is associated with development of subclinical lipid-rich atherosclerotic plaque. 16,17 Preclinical studies have confirmed vascular adhesion of platelets in early atherogenesis. In hyperlipidemic rabbits and in apolipoprotein-E-deficient mice receiving a high-fat diet, direct endothelial adhesion of ex vivo-labeled platelets at lesion-prone sites has been observed early in atherosclerosis, the extent of which increased with plaque progression.…”

Section: Platelet Activation and Adhesion In Atherogenesismentioning

confidence: 94%

Platelets and von Willebrand factor in atherogenesis

Atkinson

Lindner

2017

Blood

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The role of platelet adhesion, activation, and aggregation in acute atherothrombotic events such as myocardial infarction and stroke is well established. There is increasing evidence that platelet-endothelial interactions also contribute to early atherosclerotic plaque initiation and growth. Through these interactions, platelet-derived factors can contribute to the proinflammatory and mitogenic status of resident mural cells. Among the many putative mechanisms for platelet-endothelial interactions, increased endothelial-associated von Willebrand factor, particularly in a multimerized form, which interacts with platelet glycoproteins and integrins, is a major factor and represents a therapeutic target in early atherogenesis.

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“…Moreover, Huang et al [109] reported that increased circulating CD31+/annexin V+ EMPs and decreased circulating EPCs predict target organ damage in hypertensive patients. The higher concentrations of endothelial-derived MPs have been found in patients with acute coronary syndrome, sudden cardiac death due to acute coronary occlusion and stable angina [89]. Moreover, number of endothelial-derived MP (CD42-CD31+) closely and inversaly relate to indexes of microvascular obstruction in acute myocardial infarction patients [110].…”

Section: Endothelial Cells-derived Mpsmentioning

confidence: 99%

“…The leukocyte-derived MPs were found in higher concentrations in the patients with acute coronary syndrome and STEMI, asymptomatic atherosclerosis, obesity, diabetes, HF [89][90][91]. The monocyte CD14(+) MPs were implicated in the modulation of the post-acute coronary syndrome reparative response to injury [90].…”

Section: Leukocyte-derived Mpsmentioning

confidence: 99%

The Clinical Utility of Circulating Microparticles’ Measurement in Heart Failure Patients

Berezin¹

2016

Vasc Med Surg

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Heart failure (HF) continues to have a sufficient impact on morbidity, mortality and disability in developed countries. Growing evidence supports the hypothesis that microparticles (MPs) might contribute to the pathogenesis of the HF development paling a pivotal role in the regulation of the endogenous repair system, thrombosis, coagulation, inflammation, immunity and metabolic memory phenomenon. Therefore, there is a large body of data clarifying the predictive value of MP numerous in circulation among subjects with HF. Although determination of MP signature is better than measurement of single MP circulating level, there is not yet closely confirmation that immune phenotype of cells produced MPs are important for HF prediction and development. The aim of the review: to summarize knowledge regarding the measurement of number of various MPs subsets in HF patients.

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Possible roles of platelet-derived microparticles in atherosclerosis

Cited by 71 publications

References 76 publications

Intestinal fatty acid binding protein Ala54Thr polymorphism is associated with peripheral atherosclerosis combined with type 2 diabetes mellitus

Intestinal fatty acid binding protein Ala54Thr polymorphism is associated with peripheral atherosclerosis combined with type 2 diabetes mellitus

Platelets and von Willebrand factor in atherogenesis

The Clinical Utility of Circulating Microparticles’ Measurement in Heart Failure Patients

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