Post allogeneic stem cell transplant nephrotic syndrome secondary to de novo glomerulopathy: A case series

Abstract

Kidney disease is a frequent complication after haematopoietic stem cell transplant (SCT), with glomerulopathies reported in up to 1–6% of allogeneic SCT recipients. Membranous nephropathy is the commonest reported, followed by minimal change nephropathy. Recent work has identified a target antigen in post-SCT membranous nephropathy. We describe seven cases of post-SCT nephrotic syndrome due to de novo glomerulopathy. In the changing landscape of post-SCT glomerulopathy, we review the literature and describe how our cases demonstrate that heterogeneity of presentation and response to treatment is underscored by important clinical and histopathological factors that should be considered in the workup and management of these conditions.