Post cardiac injury syndrome after initially uncomplicated CRT-D implantation: a case report and a systematic review

Sedaghat‐Hamedani, Farbod; Zitron, Edgar; Kayvanpour, Elham; Lorenz, Hanns‐Martin; Katus, Hugo A.; Meder, Benjamin

doi:10.1007/s00392-014-0716-0

Cited by 21 publications

(30 citation statements)

References 43 publications

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“…There is also evidence showing that the autoimmune reaction might be triggered by viral infection [9,21]. Moreover, PCIS after CIED implantation may be triggered by direct irritation of the pericardium caused by slightly protruding electrodes [4]. Sex showed no significant effect on PCIS development in this study (p = 0.088).…”

Section: Discussionmentioning

confidence: 50%

“…Postcardiac injury syndrome can occur in the setting of injury to the pericardium, epicardium, or myocardium [4]; PCIS after CIED implantation is a rare complication. Its incidence in this study was 0.38%, which was lower than formerly reported [10][11][12][13].…”

Section: Discussionmentioning

confidence: 99%

“…Besides, further studies showed high levels of circulating tumor necrosis factor (TNF), interleukine-6 (IL-6), and IL-18 in patients with end-stage chronic heart failure as well as an analysis of the effect of pro-inflammatory cytokines on left ventricular (LV) remodeling and the progression of heart failure [23][24][25]. The onset of PCIS is reported from 1 day to 4 months after CIED implantation [4]. The reason for this long time span is unclear.…”

Section: Discussionmentioning

confidence: 99%

“…Bacterial infection can be ruled out with x-ray, blood and urinary culture, or procalcitonin (PCT). Further, acute diseases such as acute coronary syndrome, pulmonary embolism, or pneumonia must be ruled out first [4]. The treatment of PCIS is based on antiinflammatory therapy [4,8,26].…”

Section: Discussionmentioning

confidence: 99%

“…Postcardiac injury syndrome (PCIS) is an inflammatory response to epicardial, myocardial, or endocardial injuries. It can follow cardiac surgery, myocardial infarction, trauma, intracardiac ablation, percutaneous coronary intervention, or implantation of cardiac implantable electronic device (CIED; [1][2][3][4]). The underlying pathogenesis is thought to be an autoimmune reaction directed toward the contractile cardiac proteins, which are exposed after cardiac injury.…”

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confidence: 99%

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Postcardiac injury syndrome after cardiac implantable electronic device implantation

Filbey

Sedaghat‐Hamedani

Kayvanpour

et al. 2020

Herz

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Background Postcardiac injury syndrome (PCIS) is an inflammatory complication that derives from injury to the epicardium, myocardium, or endocardium. It occurs after trauma, myocardial infarction, percutaneous coronary intervention, cardiac surgery, intracardiac ablation, and implantation of cardiac implantable electronic device (CIED). In this study we assessed the incidence of PCIS after CIED implantation and its possible risk factors. Material and methods All patients who received CIED implantation at Heidelberg University Hospital between 2000 and 2014 were evaluated (n = 4989 patients). Clinical data including age, sex, underlying cardiac disease, type of implanted CIED, location of electrode implantation, clinical symptoms, time of symptom onset of PCIS, therapy, and outcome were extracted and analyzed. Results We identified 19 cases of PCIS in 4989 patients, yielding an incidence of 0.38%. The age of patients with PCIS ranged from 39 to 86 years. Dilated cardiomyopathy (DCM) as underlying cardiac disease and right atrial (RA) lead implantation had a significant association with occurrence of PCIS (p = 0.045 in DCM and p < 0.001 in RA lead implantation). Dyspnea, chest pain, dry cough, and fever were the most frequently reported symptoms in patients with PCIS. Pericardial and pleura effusion as well as elevated C‑reactive protein (CRP), increased erythrocyte sedimentation rate (ESR), and leukocytosis were the most common findings. Conclusion To the best of our knowledge, this is the largest cohort evaluating the incidence of PCIS after CIED implantation. The data show that PCIS is a rare complication after CIED implantation and occurs more frequently in patients with DCM and those with RA lead implantation. Although rare and mostly benign, PCIS can lead to potentially lethal complications and physicians must be aware of its symptoms.

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Section: Discussionmentioning

confidence: 50%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Postcardiac injury syndrome after cardiac implantable electronic device implantation

Filbey

Sedaghat‐Hamedani

Kayvanpour

et al. 2020

Herz

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Pericardial complications and postcardiac injury syndrome after cardiovascular implantable electronic device placement

Verma

Banerjee

Noll

et al. 2019

Herz

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Investigating the role of acute mental stress on endothelial dysfunction: a systematic review and meta-analysis

Xue

Tan

et al. 2014

Clin Res Cardiol

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Chronic stress is a known risk factor for both endothelial dysfunction and cardiovascular disease (CVD), but less is known of how acute mental stress affects the vasculature. In this systematic review and meta-analysis, we analyzed the impact of acute mental stress on flow-mediated dilation (FMD), an indicator of endothelial function. We searched the Medline, Cochrane, EMBASE, and ISI Web of Knowledge databases through May 2014, to identify publications in English-language journals. The primary outcome was the change in FMD from baseline to the time of measurement. We also assessed the risk of bias and the heterogeneity of included studies. Our search identified eight prospective studies, which displayed significant heterogeneity. Four studies measured FMD while the subject was performing the task; six measured FMD after the task had been completed. The total number of participants was 164. The pooled results indicate that FMD did not change significantly while the task was being performed (pooled difference in means: -0.853; 95 % confidence interval (CI), -3.926/2.220; P = 0.586); however, FMD measured after the task was completed was significantly less than baseline (pooled difference in means: -2.450; 95 %CI, -3.925/-0.975; P = 0.001). In conclusions, our findings provide evidence that an acute stressful experience has a delayed, negative impact on the function of the endothelium. Repeated exposure to short-term stress may lead to permanent injury of the vasculature. Therefore, assessment of patients' exposure to both repeated acute mental stress and chronic stress may be useful in determining their risk of developing CVD.

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Post cardiac injury syndrome after initially uncomplicated CRT-D implantation: a case report and a systematic review

Cited by 21 publications

References 43 publications

Postcardiac injury syndrome after cardiac implantable electronic device implantation

Postcardiac injury syndrome after cardiac implantable electronic device implantation

Pericardial complications and postcardiac injury syndrome after cardiovascular implantable electronic device placement

Investigating the role of acute mental stress on endothelial dysfunction: a systematic review and meta-analysis

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