Post COVID-19 burden: focus on the short-term condition

Yang, Fengwen; Pang, Bo; Jin, Xin; Chen, Zhe; Pang, Wentai; Liu, Qingquan; Zhang, Junhua; Zhang, Boli

doi:10.1097/hm9.0000000000000036

Cited by 6 publications

(6 citation statements)

References 32 publications

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“…The symptoms of CVST, depending on the affected vein or sinus, can mimic various neurological conditions ( Sharifian-Dorche et al, 2021 ). The fatality rate among VITT patients is alarmingly high at 30%, highlighting the need for prompt recognition and management of CVST and VITT post-vaccination ( Shafie et al, 2022 ; Fengwen et al, 2022 ; Pothiawala et al, 2022 ; Shuangming, 2023 ).…”

Section: Discussionmentioning

confidence: 99%

An overview and single-arm meta-analysis of immune-mediated adverse events following COVID-19 vaccination

Yang,

Tian,

Shen

et al. 2024

Front. Pharmacol.

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BackgroundWe conducted an overview to assess immune adverse effects associated with the COVID-19 vaccine, guiding safer choices and providing evidence-based information to clinicians.MethodsForty-three studies on adverse effects of vaccines were reviewed from PubMed, Embase, and Web of Science. Single-arm meta-analyses estimated summary effects, incidence, presentation, etc. An overview using single-arm meta-analysis and reported the findings following the guidelines outlined in the ‘Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) specifically focusing on myocarditis and thrombosis. After screening 2,591 articles, 42 studies met the inclusion criteria. Methodological quality was evaluated using AMSTAR 2. Disagreements were resolved via consensus. Data analysis utilized a random-effects model in R software to estimate incidence rates of selected adverse events.ResultsAfter removing 1,198 duplicates and screening out irrelevant articles from a total of 2,591, we included 42 studies. Adverse reactions to vaccinations include myocarditis, thrombosis, skin reactions, GBS, etc. thrombosis and myocarditis are the most dangerous diseases associated with vaccination. Myocarditis occurred in 6% of Vector vaccine recipients, compared to 61% of mRNA vaccine recipients. Thrombosis was more common after Vector vaccination (91%) than after mRNA vaccination (9%). Furthermore, eight studies conducted anti-PF4 antibody tests and yielded a positivity rate of 67%. Meta-analysis showed that among all patients with Vaccine-induced Thrombotic Thrombocytopenia, cerebral venous sinus thrombosis occurred in 66%, and intracranial hemorrhage occurred in 43%. The rates of deep vein thrombosis and pulmonary thromboembolism in vaccinated patients were 13% and 23%, respectively, with a pooled case fatality rate of 30%.ConclusionThe results of this overview indicate the majority of adverse reactions are self-limiting and require minimal intervention, while rare occurrences such as myocarditis and thrombosis pose a potentially fatal threat.

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Section: Discussionmentioning

confidence: 99%

An overview and single-arm meta-analysis of immune-mediated adverse events following COVID-19 vaccination

Yang,

Tian,

Shen

et al. 2024

Front. Pharmacol.

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“…Yang et al [ 44 ] considered that the WHO definition of post-COVID-19 condition primarily emphasizes its long-term implications, which may not be suitable for conducting early interventional studies in short-term conditions. TCM has always prioritized disease prevention, and over 2000 years ago, the ancient TCM text Huang Di Nei Jing proposed that “the upper doctor treats the untreated diseases, the middle doctor treats the desired diseases, and the lower doctor treats the existing diseases.” According to TCM theory, COVID-19 recovery period belongs to the rehabilitation stage of epidemic diseases.…”

Section: Application Of Tcm In the Recovery Period Of Covid-19mentioning

confidence: 99%

Advances in the application of traditional Chinese medicine during the COVID-19 recovery period: A review

Zhang,

Ma,

Xie

et al. 2024

Medicine

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Since the emergence of the Coronavirus Disease 2019 (COVID-19) outbreak, significant advancements has been made in research, from limited knowledge about the disease to the development of a vaccine. Although the severity of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) appears to be decreasing and the threat of COVID-19 is waning, there have been widespread concerns about persistent symptoms or sequelae experienced by some patients even after recovering from COVID-19. Traditional Chinese medicine (TCM) has shown favorable treatment outcomes during the onset of COVID-19, and extensive studies have been carried out to explore the efficacy of TCM interventions during the COVID-19 recovery period. The purpose of this review is to comprehensively analyze these studies and provide new insights for the prevention and treatment of the post-COVID-19 condition.

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“…Obstruction of the orifices results in diminishing senses of smell and taste, as well as drowsiness and forgetfulness. The disease affects the lungs, spleen, and other zang organs, and its nature is characterized by a combination of deficiencies and excesses [6][7][8][9] .…”

Section: Concept Of Common Symptoms Of Post-covid-19 Short-term Condi...mentioning

confidence: 99%

Expert consensus on the use of traditional Chinese medicine for the treatment of common symptoms of post COVID-19 short-term condition

Zhang¹,

Pang²,

Liu³

et al. 2023

Acupuncture and Herbal Medicine

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A proportion of patients who recovered from COVID-19 have ongoing, recurrent, or new symptoms with negative nucleic acid/ antigen test results, which has become a new public health problem that needs to be concerned. Traditional Chinese medicine (TCM) has shown its unique advantages in preventing, treating, and rehabilitating COVID-19. To further standardize clinician's clinical diagnosis and use of TCM for the treatment of common symptoms associated with COVID-19 infection following negative nucleic acid/antigen results, the front-line clinical experts were invited for discussion on the concepts, etiology, clinical manifestations of post-COVID-19 condition, and on treatment with TCM to form the consensus. Clinicians of TCM, Western medicine, or integration of both can use this consensus document for clinical practice and research purposes.

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Post COVID-19 burden: focus on the short-term condition

Cited by 6 publications

References 32 publications

An overview and single-arm meta-analysis of immune-mediated adverse events following COVID-19 vaccination

An overview and single-arm meta-analysis of immune-mediated adverse events following COVID-19 vaccination

Advances in the application of traditional Chinese medicine during the COVID-19 recovery period: A review

Expert consensus on the use of traditional Chinese medicine for the treatment of common symptoms of post COVID-19 short-term condition

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