Post-Diagnostic Dietary and Lifestyle Factors and Prostate Cancer Recurrence, Progression, and Mortality

Langlais, Crystal S.; Graff, Rebecca E.; Blarigan, Erin L. Van; Palmer, Nynikka R.; Washington, Samuel L.; Chan, June M.; Kenfield, Stacey A.

doi:10.1007/s11912-021-01017-x

Cited by 38 publications

(40 citation statements)

References 89 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Intake of foods from animal origin, including fish, milk, and dairy products were not associated with cancer mortality in the EPIC study [39,40], in agreement with the results of a systematic review on this issue [19]. Only in the study by Langlais et al was consumption of whole milk/high-fat dairy associated with higher risk of prostate cancer recurrence and mortality [84]. Thus, whether consumption of these foods is associated with cancer-specific mortality remains to be explored further.…”

Section: Protective Factors Against Cancer Mortalitysupporting

confidence: 82%

The Role of Diet, Alcohol, BMI, and Physical Activity in Cancer Mortality: Summary Findings of the EPIC Study

et al. 2021

View full text Add to dashboard Cite

Evidence on the impact of diet, alcohol, body-mass index (BMI), and physical activity on mortality due to cancer and other cancer-related outcomes is still scarce. Herein, we reviewed the contribution of the European Prospective Investigation into Cancer and Nutrition (EPIC) study to the current state of the art on the role of these factors in cancer mortality. We identified 45 studies using a rapid systematic review methodology. Dietary factors associated with reduced cancer mortality included raw vegetable intake; dietary fiber intake; the Mediterranean diet; other dietary scores; other diet patterns including low meat eaters, vegetarians/vegans, or fish eaters; dietary intake (or biomarkers) of some vitamins (e.g., vitamin D, vitamin K2, or Vitamin C); and intake of lignans. Physical activity and following healthy lifestyle recommendations also reduced cancer mortality risk. In contrast, dietary factors associated with higher cancer mortality risk included poor diet quality, consumption of alcohol and soft drinks including juice, and, to a lesser extent, intake of some fatty acids. Excess weight and obesity also increased the risk of cancer mortality. The EPIC study holds valuable information on diet and lifestyle factors and offers a unique opportunity to identify key diet-related factors for cancer mortality prevention.

show abstract

Section: Protective Factors Against Cancer Mortalitysupporting

confidence: 82%

The Role of Diet, Alcohol, BMI, and Physical Activity in Cancer Mortality: Summary Findings of the EPIC Study

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Additionally, Black/African-American men bear a greater burden of prostate cancer morbidity and mortality and are often under-represented in lifestyle intervention trials. 20 , 67 , 68 To address this, our team is conducting a qualitative assessment of preferences regarding diet and exercise resources for behavioral change, among non-white men with prostate cancer, to inform future tailored interventions. Overall, this pilot study suggests that in a population of more educated, white men with early-stage prostate cancer, more comprehensive (and/or longer) interventions may be needed to modify behavior to improve meaningfully QoL, sleep, and fatigue.…”

Section: Discussionmentioning

confidence: 99%

Quality of Life of Prostate Cancer Survivors Participating in a Remotely Delivered Web-Based Behavioral Intervention Pilot Randomized Trial

et al. 2022

Self Cite

View full text Add to dashboard Cite

Background: Following a prostate cancer (PC) diagnosis, treatment-related symptoms may result in diminished quality of life (QoL). Improved diet and increased exercise may improve QoL in men with PC. Methods: We conducted a 4-arm pilot randomized trial to assess feasibility and acceptability of a 3-month web-based diet and exercise intervention, among men (>18 years of age) with PC (reported elsewhere). The purpose of this study is to describe the change in QoL measured by surveys (eg, QLQ-C30, PROMIS Fatigue) at enrollment and following the intervention. Men were randomized 1:1:1:1 to increasing levels of web-based behavioral support: Level 1: website; Level 2: Level 1 plus personalized diet and exercise prescription; Level 3: Levels 1-2 plus Fitbit and text messages; Level 4: Levels 1-3 plus 2 30-minute coaching calls. T-tests were used to compare pre-post change in mean QoL scores between each Level and Level 1. Results: Two hundred and two men consented and were randomized (n = 49, 51, 50, 52 for Levels 1-4, respectively). Men were predominantly white (93%), with a median age of 70 years (Intra-quartile Range [IQR]: 65,75) and 3 years (IQR: 1,9) post primary treatment for mostly localized disease (74% with T1-2). There were no meaningful changes in QoL, but there were notable trends. Level 3 participants had small improvements in QLQ-C30 Global Health (5.46; 95% CI: −0.02, 10.95) compared to Level 1. In contrast, Level 2 participants trended toward decreasing Global QoL (−2.31, 95% CI: −8.05, 3.42), which may reflect declines in function (eg, Cognitive: −6.94, 95% CI: −13.76, −0.13) and higher symptom burden (eg, Diarrhea: 4.63, 95% CI: −1.48, 10.74). Conclusions: This short, web-based intervention did not appear to have an impact on PC survivors’ QoL. Most men were several years past treatment for localized disease; the potential for this approach to reduce symptoms and improve QoL in men who have worse health may still be warranted.

show abstract

“…PCa, as one of the most common malignant tumors, has the second highest incidence and the sixth highest mortality worldwide ( 1 , 2 ) Although the incidence of PCa in China is far less likely to that in Western countries, its growth in the developing country is much faster ( 3 , 4 ). As China gradually enters the aging society, PCa will become the main tumor “killer” that endangers the health of elderly men; therefore, the clinical diagnosis and treatment of PCa and its basic study have entered an urgent stage ( 5 ).…”

Section: Discussionmentioning

confidence: 99%

“…Prostate cancer (PCa) is one of the most common malignancies among men in Western countries and the second most common malignancies in the United States ( 1 , 2 ). It is reported that 191,930 new cases and 33,330 new deaths of PCa were found among all men in the United States in 2020 ( 3 , 4 ). The incidence of PCa varies among different ethnic groups, which is relatively low in China compared with Western countries ( 4 ).…”

Section: Introductionmentioning

confidence: 99%

“…It is reported that 191,930 new cases and 33,330 new deaths of PCa were found among all men in the United States in 2020 ( 3 , 4 ). The incidence of PCa varies among different ethnic groups, which is relatively low in China compared with Western countries ( 4 ). The early symptoms of PCa are insidious, often without any clinical manifestation, and the clinical stage of PCa is often advanced when the clinical symptoms, such as dysuria and urinary retention, and so on, are found ( 5 ).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Up-Regulation of LINC00665 Facilitates the Malignant Progression of Prostate Cancer by Epigenetically Silencing KLF2 Through EZH2 and LSD1

et al. 2021

View full text Add to dashboard Cite

This study aimed to explore the function of LINC00665 on the proliferation and metastasis of prostate cancer (PCa), and the potential regulatory mechanisms were also investigated. The expression level of LINC00665 in 50 pairs of PCa tissues and adjacent ones was studied by qRT-PCR, and the associations between LINC00665 and clinicopathological characteristics of PCa patients were analyzed. Control group (sh-NC) and LINC00665 knock-down group (sh-LINC00665) were set in 22RV1 and DU145 cells, respectively. The biological functions of LINC00665 in PCa cell lines were assessed by CCK-8, EdU, Transwell assays, and the nude mouse xenograft model was used to evaluate the tumorigenicity in vivo. In addition, qRT-PCR, Western Blot, RIP and ChIP assays were also used to determine the regulation mechanism of LINC00665 in PCa cell lines. In this study, our results showed that LINC00665 expression level in PCa cancer tissues was significantly up-regulated, compared with that in adjacent ones. Besides, similar results were found in PCa cell lines. Knock-down of LINC00665 significantly attenuated the proliferation and migration ability in 22RV1 and DU145 cells, compared to sh-NC. Mechanically, LINC00665 could interact with EZH2 and LSD1, recruiting them to KLF2 promoter region to inhibit its transcription. Moreover, the tumor-suppressive effects mediated by sh-LINC00665 were significantly reversed through the down-regulation of KLF2. Also, the suppression of LINC00665 impaired tumor growth of PCa in vivo. In summary, LINC00665 exerted the oncogenic functions in PCa cell lines by epigenetically silencing KLF2 expression by binding to EZH2 and LSD1, illuminating a novel mechanism of LINC00665 in the malignant progression of PCa and furnishing a prospective therapeutic biomarker to combat PCa.

show abstract

Post-Diagnostic Dietary and Lifestyle Factors and Prostate Cancer Recurrence, Progression, and Mortality

Cited by 38 publications

References 89 publications

The Role of Diet, Alcohol, BMI, and Physical Activity in Cancer Mortality: Summary Findings of the EPIC Study

The Role of Diet, Alcohol, BMI, and Physical Activity in Cancer Mortality: Summary Findings of the EPIC Study

Quality of Life of Prostate Cancer Survivors Participating in a Remotely Delivered Web-Based Behavioral Intervention Pilot Randomized Trial

Up-Regulation of LINC00665 Facilitates the Malignant Progression of Prostate Cancer by Epigenetically Silencing KLF2 Through EZH2 and LSD1

Contact Info

Product

Resources

About