Post hoc analysis of initial treatments and control status in the INITIAL study: an observational study of newly diagnosed patients with asthma

Lin, Jiangtao; Fu, Xue Jun; Jiang, Ping; Song, Weidong; Hu, Xiaoyun; Zhang, Jie; Liu, Chuntao; He, Zhengguang; Zhou, Xiangdong; Tang, Huaping

doi:10.1186/s12890-020-1069-2

Cited by 2 publications

(1 citation statement)

References 22 publications

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“…According to GINA, low to medium doses of ICS are adequate for most patients with asthma to fully achieve clinical benefits 7 . Consistent with a previous study by Lin et al 23 , ICS+LABA+LTRA and ICS+LABA were the two most common combinations for controller therapy indicated in our study. ICS+LABA is the preferred controller therapy recommended by the 2019 GINA guideline for patients at treatment step 3 or above.…”

Section: Discussionsupporting

confidence: 93%

Asthma control and medication adherence among asthmatic outpatients in Vietnam: A cross-sectional study

Huynh¹,

Nguyen²,

Nguyen³

2022

Pharm Sci Asia

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Asthma is a heterogeneous disease of which the main characteristic is chronic airway inflammation which results in respiratory symptoms such as cough, wheezing, shortness of breath, and chest tightness 1 . Asthma is a major global public health concern with approximately 339 million people affected in 2018 and 1,000 people dying due to asthma-related problems every day 2 . In Vietnam, asthma remains a health and economic burden. The estimated prevalence among adults ranged from 2.4%-6.0% in 2011 and the total cost of asthma was 23,165 billion Vietnam Dong (VND) in 2014 [3][4][5][6] .According to the Global Initiative for Asthma (GINA), the important goals of asthma management are to gain good control of asthma symptoms and to minimize the risk of future asthma-related consequences 1 . Uncontrolled asthma is associated with many adverse outcomes, namely decreased lung function, increased risk of life-threatening asthma exacerbation, poor quality of life, and increased treatment cost 1 . To achieve asthma control, pharmacological controller therapy is of critical importance. Inhaled corticosteroids (ICS) are strongly recommended by the GINA guidelines as a crucial component in the controller therapy for all adolescents and adults with asthma 1,7 . Despite the advances in management, the availability of established treatment guidelines, and effective treatment therapy, poorly-controlled asthma

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Section: Discussionsupporting

confidence: 93%

Asthma control and medication adherence among asthmatic outpatients in Vietnam: A cross-sectional study

Huynh¹,

Nguyen²,

Nguyen³

2022

Pharm Sci Asia

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Bronchial asthma in children of Mongolia: prevalence and risk factors

Tsevegmid

Orosoo

Javzandorj

et al. 2022

RPJ

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Introduction. The peculiarity of this work is to determine the prevalence of bronchial asthma (BA) in children and the risk factors for its development in Mongolia. This country is intensively developing economically and is at the stage of transition to an industrial society, which allows assessing the impact of environmental and population changes on the frequency of BA formation. The aim of the work is to determine the prevalence and risk factors for the development of BA in children of Mongolia. Materials and methods. The prevalence of BA and data on patients aged from birth to 19 years living in Ulaanbaatar, 17 aimags and six districts of Mongolia were studied using a modified written questionnaire. To determine the prevalence of BA, we surveyed parents and 1,779 BA children patients. Information on biomedical and socio-hygienic risk factors for the development of BA in children of Mongolia was obtained after analyzing the data of a special questionnaire from 1,507 schoolchildren. All the received data are processed statistically. Results. The prevalence of BA in children of Mongolia was found to account for 11 per 1,000 children. The highest incidence of BA in children was found mainly in the northern regions of Mongolia, with a sharply continental climate and high air pollution. Among the risk factors for the formation of BA in children, the most significant are burdened heredity, smoking, unfavourable living conditions, pregnancy pathology, Breastfeeding disorders in the newborn period, irrational nutrition of the child, acute respiratory infections. In 50% of BA patients, a significant increase in eosinophils was revealed. 61.2% of patients had an increased level of IgE. Regardless of the region of residence of BA children, polyvalent pollen sensitization was the most frequent - 59.3%, food allergy - 55.5%, epidermal allergy - 38.3% of cases, household (8.3%) and fungal sensitization (5%) were rarely detected. Treatment of 89 BA children in the National Center for Maternal and Child Health hospital under the Global Initiative for Asthma strategy helped improve patients’ condition.

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Post hoc analysis of initial treatments and control status in the INITIAL study: an observational study of newly diagnosed patients with asthma

Cited by 2 publications

References 22 publications

Asthma control and medication adherence among asthmatic outpatients in Vietnam: A cross-sectional study

Asthma control and medication adherence among asthmatic outpatients in Vietnam: A cross-sectional study

Bronchial asthma in children of Mongolia: prevalence and risk factors

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