Post-kala-azar dermal leishmaniasis

Current diagnosis and treatment of cutaneous and mucocutaneous leishmaniasis

“…In some cases, L. (L.) tropica infection evolves to a relapsing lesion known as leishmaniasis recidiva cutis or leishmaniasis recidivans [11], or mucosal leishmaniasis (ML) [12], and L. (L.) aethiopica infection to diffuse cutaneous leishmaniasis (DCL) [11]. In addition, L. (L.) donovani may determine PKDL [13]. The species present in the New World determine more varied clinical manifestations, including the aggressive and destructive ML.…”

“…DCL patients provide a negative test [61]. In 11% of patients with PKDL and concomitant visceral leishmaniasis, the Montenegro test is positive, and in those without concomitant visceral leishmaniasis, 37% are positive [13].…”

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“…It has been estimated that from 30 to 40 thousand people died in this epidemic (Davidson & Croft 1992) and that it is still rampant (Moszynski 2002). One of the alarming consequences of this besides the high death rate is that it has been estimated that 50% of the treated cases develop post dermal kala-azar (PKDL) which normally cures spontaneously (Zijlstra et al 2003). However, such cases could serve as reservoirs of infection.…”

Repair of Impaired Host Peroxisomal Properties Cropped Up Due to Visceral Leishmaniasis May Lead to Overcome Peroxisome Related Genetic Disorder Which May Develop Later After Treatment

“…Considering the knowledge we have gathered from the present work, it is clearly established that the peroxisomes, that get damaged during Leishmania infection are morphologically repaired after treatment with a common antileishmanial afent SAG, but the biochemical properties are not restored back. PKDL is a common problem 178,179 in kala azar patients but the actual reason behind the occurence of this disease is not yet known. Several peroxiomal disordes like ZS, IRD etc are also reported.…”