Post-Meiotic DNA Damage and Response in Male Germ Cells

Leduc, Frédéric; Acteau, Geneviève; Grégoire, Marie-Chantal; Simard, O.; Leroux, Jessica; Carrier-Leclerc, Audrey; Arguin, Mélina; Boissonneault, Guylain

doi:10.5772/21367

DNA Repair 2011

DOI: 10.5772/21367

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Post-Meiotic DNA Damage and Response in Male Germ Cells

Frédéric Leduc¹,

Geneviève Acteau²,

Marie-Chantal Grégoire³

et al.

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Cited by 2 publications

References 145 publications

(172 reference statements)

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The DNA double-strand “breakome” of mouse spermatids

Grégoire

Leduc

Morin

et al. 2018

Cell. Mol. Life Sci.

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De novo germline mutations arise preferentially in male owing to fundamental differences between spermatogenesis and oogenesis. Post-meiotic chromatin remodeling in spermatids results in the elimination of most of the nucleosomal supercoiling and is characterized by transient DNA fragmentation. Using three alternative methods, DNA from sorted populations of mouse spermatids was used to confirm that double-strand breaks (DSB) are created in elongating spermatids and repaired at later steps. Specific capture of DSB was used for whole-genome mapping of DSB hotspots (breakome) for each population of differentiating spermatids. Hotspots are observed preferentially within introns and repeated sequences hence are more prevalent in the Y chromosome. When hotspots arise within genes, those involved in neurodevelopmental pathways become preferentially targeted reaching a high level of significance. Given the non-templated DNA repair in haploid spermatids, transient DSBs formation may, therefore, represent an important component of the male mutation bias and the etiology of neurological disorders, adding to the genetic variation provided by meiosis.

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The DNA double-strand “breakome” of mouse spermatids

Grégoire

Leduc

Morin

et al. 2018

Cell. Mol. Life Sci.

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Torsional stress promotes trinucleotidic expansion in spermatids

Simard

Niavarani

Gaudreault

et al. 2017

Mutation Research/Fundamental and Molecular Mechanisms of Mutag

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Post-Meiotic DNA Damage and Response in Male Germ Cells

Cited by 2 publications

References 145 publications

The DNA double-strand “breakome” of mouse spermatids

The DNA double-strand “breakome” of mouse spermatids

Torsional stress promotes trinucleotidic expansion in spermatids

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