Post-mortem computed tomography angiography: past, present and future

Saunders, Sarah; Morgan, Bruno; Raj, Vimal; Rutty, Guy N.

doi:10.1007/s12024-010-9208-3

Cited by 82 publications

(40 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Only a few recent studies have addressed this topic [12][13][14]. Saunders et al [13] presented the developmental stages for manual targeted in situ postmortem angiography using injections of air/Urografin Ò and demonstrated that large volumes of air and contrast can be injected without displacing the thrombi.…”

Section: Discussionmentioning

confidence: 99%

“…At the same time, some pioneer studies involving postmortem MDCTangiography and cardiac pathologies have recently been published [11][12][13] describing the potential to overcome these weaknesses. Several authors suggest that the major limitations concerning cardio-vascular pathology could be minimized by the introduction of postmortem angiography [12,14,15]. In our practice, native MDCT has become part of the routine investigation.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Evaluation of postmortem MDCT and MDCT-angiography for the investigation of sudden cardiac death related to atherosclerotic coronary artery disease

Michaud

Grabherr

Doenz

et al. 2012

Int J Cardiovasc Imaging

101

View full text Add to dashboard Cite

The goal of this study was to evaluate the diagnostic value of postmortem multi-computed tomography (MDCT) and MDCT-angiography for sudden cardiac deaths related to ischemic heart disease. Twenty three cases were selected based on clinical history and the results of native MDCT, multiphase post-mortem CT-angiography and conventional autopsy were compared. Radiological examination showed calcification of coronary arteries in 78% of the cases, most of which were not detailed at autopsy. MDCT-angiography allowed better visualization of the coronary arteries than MDCT and permitted the evaluation of stenoses and occlusions. Of the 14 cases of coronary thrombosis detected at conventional autopsy, 11 were visible as stop of perfusion with CT-angiography and three were found to be partly perfused. One case had an old thrombosis with collateral circulation. One case had a coronary artery postmortem clot found with MDCT-angiography. Coronary artery calcifications are more easily detected and documented with radiological examination than with conventional autopsy. MDCT is of limited diagnostic value for ischemic heart disease. MDCT-angiography, when correctly interpreted, is a reasonable tool to view the morphology of coronary arteries, rule out significant coronary artery stenoses, identify occlusions and direct sampling for histological examination.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Evaluation of postmortem MDCT and MDCT-angiography for the investigation of sudden cardiac death related to atherosclerotic coronary artery disease

Michaud

Grabherr

Doenz

et al. 2012

Int J Cardiovasc Imaging

101

View full text Add to dashboard Cite

show abstract

“…Following this example, researchers started using contrast media in PMCT, and PMCT-angiography (PMCTA) was introduced. 15 In recent years, the number of publications concerning PMCTA has increased significantly, signalling that research teams all over the world started to develop techniques for the injection of contrast agent into the body of the deceased and thus perform post-mortem angiography (PMA).…”

mentioning

confidence: 99%

Advances in post-mortem CT-angiography

Grabherr¹,

Grimm²,

Domínguez³

et al. 2014

BJR

119

View full text Add to dashboard Cite

Performing a post-mortem multidetector CT (MDCT) scan has already become routine in some institutes of forensic medicine. To better visualize the vascular system, different techniques of post-mortem CT-angiography have been explored, which can essentially be divided into partial-and whole-body angiography techniques. Probably the most frequently applied technique today is the so-called multiphase post-mortem CT-angiography (MPMCTA) a standardized method for investigating the vessels of the head, thorax and abdomen. Different studies exist, describing its use for medicolegal investigations, and its advantages as well as its artefacts and pitfalls. With the aim to investigate the performance of PMCTA and to develop and validate techniques, an international working group was created in 2012 called the "Technical Working Group Post-mortem Angiography Methods" (TWGPAM). Beyond its primary perspective, the goals of this group include creating recommendations for the indication of the investigation and for the interpretation of the images and to distribute knowledge about PMCTA. This article provides an overview about the different approaches that have been developed and tested in recent years and an update about ongoing research in this field. It will explain the technique of MPMCTA in detail and give an outline of its indications, application, advantages and limitations.

show abstract

“…Postmortem angiography is becoming increasingly prominent in forensic pathology as an adjunct to conventional autopsy [1][2][3]. Despite its numerous advantages, forensic pathologists and toxicologists have questioned certain elements of this technique.…”

Section: Introductionmentioning

confidence: 99%

Postmortem biochemistry performed on vitreous humor after postmortem CT-angiography

et al. 2012

View full text Add to dashboard Cite

a b s t r a c tPostmortem angiography is becoming increasingly essential in forensic pathology as an adjunct to con-ventional autopsy. Despite the numerous advantages of this technique, some questions have been raised regarding the influence of the contrast agent injected on the results of toxicological and biochemical anal-yses. The aim of this study was to investigate the effect of the injection of the contrast agent Angiofil Ò , mixed with paraffin oil, on the results of postmortem biochemical investigations performed on vitreous humor. Postmortem biochemical investigations were performed on vitreous samples collected from bodies that had undergone postmortem angiography (n = 50) and from a control group (n = 50). Two vit-reous samples were analyzed for each group and the results compared. Glucose, urea, creatinine, 3-b-hydroxybutyrate, sodium and chloride were tested. Different values were observed between the first and second samples in each group. However, these differences were not clinically relevant, suggesting that the injection of this contrast agent mixture does not modify the concentration of the analyzed sub-stances in the vitreous humor.

show abstract

Post-mortem computed tomography angiography: past, present and future

Cited by 82 publications

References 23 publications

Evaluation of postmortem MDCT and MDCT-angiography for the investigation of sudden cardiac death related to atherosclerotic coronary artery disease

Evaluation of postmortem MDCT and MDCT-angiography for the investigation of sudden cardiac death related to atherosclerotic coronary artery disease

Advances in post-mortem CT-angiography

Postmortem biochemistry performed on vitreous humor after postmortem CT-angiography

Contact Info

Product

Resources

About