2021
DOI: 10.1016/j.jstrokecerebrovasdis.2021.106082
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Post-Stroke Depression in Patients with Large Spontaneous Intracerebral Hemorrhage

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Cited by 12 publications
(15 citation statements)
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“…In a secondary analysis of a randomized, multicenter, placebo-controlled trial among 308 patients with spontaneous intracranial hemorrhage who completed the Center for Epidemiologic Studies Depression Scale, poststroke depression occurred in 36% of patients at 180 days. 256 Correlates of depression included female sex (aOR, 1.93, [95% CI, 1.07–3.48]), Hispanic ethnicity (aOR, 3.05 [95% CI, 1.19–7.85]), intraventricular hemorrhage (aOR, 1.88 [95% CI, 1.02–3.45]), right-sided lesions (aOR, 3.00 [95% CI, 1.43–6.29]), impaired cognition at day 30 (aOR, 2.50 [95% CI, 1.13–5.54]), and not being at home at day 30 (aOR, 3.17 [95% CI, 1.05–9.57]).…”
Section: Stroke (Cerebrovascular Diseases)mentioning
confidence: 99%
“…In a secondary analysis of a randomized, multicenter, placebo-controlled trial among 308 patients with spontaneous intracranial hemorrhage who completed the Center for Epidemiologic Studies Depression Scale, poststroke depression occurred in 36% of patients at 180 days. 256 Correlates of depression included female sex (aOR, 1.93, [95% CI, 1.07–3.48]), Hispanic ethnicity (aOR, 3.05 [95% CI, 1.19–7.85]), intraventricular hemorrhage (aOR, 1.88 [95% CI, 1.02–3.45]), right-sided lesions (aOR, 3.00 [95% CI, 1.43–6.29]), impaired cognition at day 30 (aOR, 2.50 [95% CI, 1.13–5.54]), and not being at home at day 30 (aOR, 3.17 [95% CI, 1.05–9.57]).…”
Section: Stroke (Cerebrovascular Diseases)mentioning
confidence: 99%
“…In a secondary analysis of a randomized, multicenter, placebo-controlled trial among 308 patients with spontaneous intracranial hemorrhage who completed the Center for Epidemiologic Studies Depression Scale, poststroke depression occurred in 36% of patients at 180 days. 218 Correlates of depression included female sex (aOR, 1.93, [95% CI, 1.07–3.48]), Hispanic ethnicity (aOR, 3.05 [95% CI, 1.19–7.85]), intraventricular hemorrhage (aOR, 1.88 [95% CI, 1.02–3.45]), right-sided lesions (aOR, 3.00 [95% CI, 1.43–6.29]), impaired cognition at day 30 (aOR, 2.50 [95% CI, 1.13–5.54]), and not being at home at day 30 (aOR, 3.17 [95% CI, 1.05–9.57]).…”
Section: Stroke (Cerebrovascular Diseases)mentioning
confidence: 99%
“…[ 53 ] Cytokines (IL-1, IL-2, IL-6, TNF- α) could promote the gene expression of indoleamine 2,3-dioxygenase, metabolize tryptophan into canine uric acid, transfer tryptophan from 5-HT synthesis, reduce the content of 5-HT in the frontal cortex and basal ganglia. [ 54 ] The physiological change could contribute to the onset of depression. Some studies have also shown that the peripheral immune inflammatory reaction caused by acute stroke is related to PSD, but the exact mechanism has yet to be unveiled.…”
Section: Discussionmentioning
confidence: 99%